Nmnat1 - nicotinamide nucleotide adenylyltransferase 1 Gene

Also Known as nmnat; D4Cole1e; 2610529L11Rik; 5730441G13Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 66454

Summary

Enables nicotinamide-nucleotide adenylyltransferase activity and nicotinate-nucleotide adenylyltransferase activity. Involved in negative regulation of neuron death. Acts upstream of or within NAD biosynthetic process and response to wounding. Located in nucleus. Used to study Leber congenital amaurosis 9 and retinal degeneration. Human ortholog(s) of this gene implicated in Leber congenital amaurosis 9 and spondyloepiphyseal dysplasia, sensorineural hearing loss, intellectual developmental disorder, and Leber congenital amaurosis. Orthologous to human NMNAT1 (nicotinamide nucleotide adenylyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]

Nmnat1 Products (2)

mRNA Protein Name
NM_001356357.1 NP_001343286.1 nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1
NM_133435.2 NP_597679.1 nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables nicotinamide-nucleotide adenylyltransferase activity IDA
IDA: Inferred from direct assay
16914673 MGI
enables nicotinate-nucleotide adenylyltransferase activity IDA
IDA: Inferred from direct assay
15381699 MGI
enables protein ADP-ribosyltransferase-substrate adaptor activity IDA
IDA: Inferred from direct assay
32822587 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within NAD biosynthetic process IDA
IDA: Inferred from direct assay
15381699 MGI
involved in NAD biosynthetic process IMP
IMP: Inferred from mutant phenotype
27735788 MGI
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
32822587 MGI
acts upstream of or within response to wounding IDA
IDA: Inferred from direct assay
16914673 MGI
Cellular Component GO Annotation Evidence References Source
is active in chromatin IDA
IDA: Inferred from direct assay
32822587 MGI
located in chromatin IDA
IDA: Inferred from direct assay
32822587 MGI
located in nucleus IDA
IDA: Inferred from direct assay
15381699 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1

  • NMN adenylyltransferase 1

  • NMN/NaMN adenylyltransferase 1

  • naMN adenylyltransferase 1

  • nicotinamide mononucleotide adenylyl transferase

  • nicotinamide mononucleotide adenylyltransferase 1

  • nicotinamide/nicotinate mononucleotide adenylyltransferase 1

  • nicot

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-W615108B β-Nicotinamide mononucleotide, reduced form disodium 99.55% Unkown
HY-161712 IMPDH-IN-4 Inhibitor 99.76% Unkown
HY-RS09382 NMNAT1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18008 Nmnat1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24481 Nmnat1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nmnat1 NCBI NCBI:64802