β-Nicotinamide mononucleotide, reduced form disodium
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β-Nicotinamide mononucleotide, reduced form (NMNH) disodium is an orally active reduced version of β-Nicotinamide mononucleotide (HY-F0004). β-Nicotinamide mononucleotide, reduced form disodium can significantly increase the levels of NAD+ and NADH, inhibit glycolysis, the tricarboxylic acid cycle, and cell growth, with its effects being dependent on nicotinamide mononucleotide adenylyltransferase (NMNAT).
For research use only. We do not sell to patients.
- Purity: 99.55%
- CAS No.: 108347-85-9
- Formula: C11H15N2Na2O8P
- Molecular Weight:380.20
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Storage:
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Endogenous Metabolite Isoforms
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Biological Activity
β-Nicotinamide mononucleotide, reduced form (100 μM; 12 h) disodium can significantly increase the level of NAD+ in HepG2 cells and reduce the levels of glycolysis and TCA cycle intermediates[1].
β-Nicotinamide mononucleotide, reduced form (250-1000 μM; 12-72 h) disodium can inhibit the growth of HepG2 cells and induce cell cycle arrest[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HepG2 cells
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Concentration:10, 50, 100, 250 and 500 μM
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Incubation Time:72 h
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Result:Inhibited HepG2 cell growth at concentrations higher than 250 μM.
β-Nicotinamide mononucleotide, reduced form (250 mg/kg; intraperitoneal injection; single dose) disodium can increase the NAD+ levels by 2-5 times in tissues such as the liver, kidney, brain, muscle, and whole blood of C57BL/6J mice[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 108347-85-9
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Appearance Solid
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Molecular Weight 380.20
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Formula C11H15N2Na2O8P
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Color Light yellow to yellow
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SMILES
O[C@H]1[C@@H](O)[C@H](N2C=C(CC=C2)C(N)=O)O[C@@H]1COP(O[Na])(O[Na])=O
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Synonyms
NMNH disodium
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Solvent & Solubility
H2O : ≥ 100 mg/mL (263.02 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (277 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
[1]. Liu Y, et al. Reduced Nicotinamide Mononucleotide (NMNH) Potently Enhances NAD+ and Suppresses Glycolysis, the TCA Cycle, and Cell Growth. J Proteome Res. 2021 May 7;20(5):2596-2606. [Content Brief]
[2]. Zapata-Pérez R, et al. Reduced nicotinamide mononucleotide is a new and potent NAD+ precursor in mammalian cells and mice. FASEB J. 2021 Apr;35(4):e21456. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 2.6302 mL | 13.1510 mL | 26.3019 mL | 65.7549 mL |
| 5 mM | 0.5260 mL | 2.6302 mL | 5.2604 mL | 13.1510 mL | |
| 10 mM | 0.2630 mL | 1.3151 mL | 2.6302 mL | 6.5755 mL | |
| 15 mM | 0.1753 mL | 0.8767 mL | 1.7535 mL | 4.3837 mL | |
| 20 mM | 0.1315 mL | 0.6575 mL | 1.3151 mL | 3.2877 mL | |
| 25 mM | 0.1052 mL | 0.5260 mL | 1.0521 mL | 2.6302 mL | |
| 30 mM | 0.0877 mL | 0.4384 mL | 0.8767 mL | 2.1918 mL | |
| 40 mM | 0.0658 mL | 0.3288 mL | 0.6575 mL | 1.6439 mL | |
| 50 mM | 0.0526 mL | 0.2630 mL | 0.5260 mL | 1.3151 mL | |
| 60 mM | 0.0438 mL | 0.2192 mL | 0.4384 mL | 1.0959 mL | |
| 80 mM | 0.0329 mL | 0.1644 mL | 0.3288 mL | 0.8219 mL | |
| 100 mM | 0.0263 mL | 0.1315 mL | 0.2630 mL | 0.6575 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
β-Nicotinamide mononucleotide, reduced form disodium Related Classifications
HY-W615108B Related Classifications
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