Aspn - asporin Gene

Also Known as Plap1; Slrr1c; 4631401G09Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 66695

Summary

This gene encodes a member of the small leucine-rich proteoglycan family. The encoded protein is an extracellular matrix protein that modulates the transforming growth factor-beta signaling pathway, regulating cartilage matrix gene expression and cartilage formation. The protein plays a role in the pathology of osteoarthritis. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Feb 2010]

Aspn Products (2)

mRNA Protein Name
NM_001172481.1 NP_001165952.1 asporin preproprotein
NM_025711.3 NP_079987.2 asporin preproprotein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables protein binding IPI
IPI: Inferred from physical interaction
17522060 MGI
Biological Process GO Annotation Evidence Références Source
involved in negative regulation of tooth mineralization IDA
IDA: Inferred from direct assay
17522060 MGI
involved in negative regulation of transforming growth factor beta receptor signaling pathway IDA
IDA: Inferred from direct assay
17827158 MGI
Cellular Component GO Annotation Evidence Références Source
located in extracellular matrix IDA
IDA: Inferred from direct assay
11152692 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

asporin

  • periodontal ligament-associated protein 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-E70196 Endoproteinase Asp-N (MS grade) Inhibitor / Unkown
HY-RS01105 ASPN Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17447 Aspn Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23903 Aspn Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Aspn NCBI NCBI:54829