Gipc1 - GIPC PDZ domain containing family, member 1 Gene

Also Known as GIPC; TIP-2; TaxIP2; Semcap1; Glut1CIP; Rgs19ip1

Species: Mus musculus

Gene Type: protein coding

Gene ID: 67903

Summary

Enables actin binding activity; identical protein binding activity; and Myosin binding activity. Involved in several processes, including negative regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of transforming growth factor beta receptor signaling pathway; and regulation of synaptic vesicle exocytosis. Acts upstream of or within several processes, including cellular response to interleukin-7; endothelial cell migration; and glutamate secretion. Located in several cellular components, including Schaffer collateral - CA1 synapse; dendrite; and glutamatergic synapse. Is active in postsynapse and presynapse. Is expressed in several structures, including brain; future brain; genitourinary system; hemolymphoid system gland; and sensory organ. Orthologous to human GIPC1 (GIPC PDZ domain containing family member 1). [provided by Alliance of Genome Resources, Apr 2022]

Gipc1 Products (1)

mRNA	Protein	Name
NM_018771.3	NP_061241.1	PDZ domain-containing protein GIPC1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables actin binding	IPI IPI: Inferred from physical interaction	15975910	MGI
enables identical protein binding	IPI IPI: Inferred from physical interaction	15975910	MGI
enables myosin binding	IPI IPI: Inferred from physical interaction	16908842	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	9770488	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within cellular response to interleukin-7	IDA IDA: Inferred from direct assay	29581031	MGI
acts upstream of or within chemical synaptic transmission	IMP IMP: Inferred from mutant phenotype	16819522	MGI
acts upstream of or within endothelial cell migration	IMP IMP: Inferred from mutant phenotype	16467373	MGI
acts upstream of or within glutamate secretion	IMP IMP: Inferred from mutant phenotype	16819522	MGI
involved in negative regulation of proteasomal ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	11546783	MGI
involved in positive regulation of transforming growth factor beta receptor signaling pathway	IDA IDA: Inferred from direct assay	11546783	MGI
involved in presynaptic modulation of chemical synaptic transmission	IDA IDA: Inferred from direct assay	16819522	MGI
involved in presynaptic modulation of chemical synaptic transmission	IMP IMP: Inferred from mutant phenotype	16819522	MGI
acts upstream of or within protein targeting	IMP IMP: Inferred from mutant phenotype	16467373	MGI
acts upstream of or within protein targeting	IPI IPI: Inferred from physical interaction	15975910	MGI
involved in regulation of protein stability	IDA IDA: Inferred from direct assay	11546783	MGI
acts upstream of or within regulation of synaptic plasticity	IMP IMP: Inferred from mutant phenotype	16819522	MGI

Cellular Component GO Annotation	Evidence	References	Source
is active in Schaffer collateral - CA1 synapse	IDA IDA: Inferred from direct assay	16819522	MGI
is active in Schaffer collateral - CA1 synapse	IMP IMP: Inferred from mutant phenotype	16819522	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	16819522	MGI
located in cytosol	IDA IDA: Inferred from direct assay	9770488	MGI
located in dendritic shaft	IDA IDA: Inferred from direct assay	16819522	MGI
located in dendritic spine	IDA IDA: Inferred from direct assay	16819522	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	16819522	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	16819522	MGI
located in membrane	IDA IDA: Inferred from direct assay	9770488	MGI
located in synaptic vesicle	IDA IDA: Inferred from direct assay	16819522	MGI
located in vesicle membrane	IDA IDA: Inferred from direct assay	15975910	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
PDZ domain-containing protein GIPC1	GAIP C-terminus-interacting protein RGS-GAIP interacting protein GIPC RGS-GAIP-interacting protein RGS19-interacting protein 1 SEMCAP-1 Tax interacting protein, clone 2 neurophilin1-IP regulator of G-protein signaling 19 interacting protein 1 sema

Gipc1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Gipc1	Q9Z0G0	Lrp2	Mus musculus	A2ARV4	Pull Down	10827173
Cross	Gipc1	Q9Z0G0	MYO6	Homo sapiens	Q9UM54	Anti Tag CoIP	16908842
Cross	Gipc1	Q9Z0G0	MYO6	Homo sapiens	Q9UM54	Pull Down	16908842
Intra	Gipc1	Q9Z0G0	Sema4c	Mus musculus	Q64151	Y2H	10318831
Intra	Gipc1	Q9Z0G0	Sema4c	Mus musculus	Q64151	Pull Down	10318831
Intra	Gipc1	Q9Z0G0	Sema4c	Mus musculus	Q64151	Anti Bait CoIP	10318831

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05435	GIPC1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Gipc1	NCBI	NCBI:10755