TFDP2 - transcription factor Dp-2 Gene

Also Known as DP2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 7029

About TFDP2

Cytogenetic location: 3q23 Genomic coordinates (GRCh38): 3:141,944,428-142,149,544 (from NCBI)

This gene has 24 transcripts (splice variants), 159 orthologues and 2 paralogues. Ubiquitous expression in ovary (RPKM 7.2), testis (RPKM 6.9) and 25 other tissues.

Summary

The gene is a member of the transcription factor DP family. The encoded protein forms heterodimers with the E2F transcription factors resulting in transcriptional activation of cell cycle regulated genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

TFDP2 Products (14)

mRNA Protein Name
NM_001178138.2 NP_001171609.1 transcription factor Dp-2 isoform 1
NM_001178139.2 NP_001171610.1 transcription factor Dp-2 isoform 2
NM_001178140.2 NP_001171611.1 transcription factor Dp-2 isoform 3
NM_001178141.2 NP_001171612.1 transcription factor Dp-2 isoform 4
NM_001178142.2 NP_001171613.1 transcription factor Dp-2 isoform 5
NM_001375756.1 NP_001362685.1 transcription factor Dp-2 isoform 6
NM_001375773.1 NP_001362702.1 transcription factor Dp-2 isoform 7
NM_001375774.1 NP_001362703.1 transcription factor Dp-2 isoform 8
NM_001375775.1 NP_001362704.1 transcription factor Dp-2 isoform 9
NM_001375776.1 NP_001362705.1 transcription factor Dp-2 isoform 1
NM_001375778.1 NP_001362707.1 transcription factor Dp-2 isoform 6
NM_001375779.1 NP_001362708.1 transcription factor Dp-2 isoform 10
NM_001375780.1 NP_001362709.1 transcription factor Dp-2 isoform 10
NM_006286.5 NP_006277.1 transcription factor Dp-2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
contributes to DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
7739537 GOA
contributes to RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
7739537 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16061792 GOA
enables protein domain specific binding IPI
IPI: Inferred from physical interaction
16360038 GOA
enables transcription factor binding IPI
IPI: Inferred from physical interaction
7784053 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
20176812 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
7739537 GOA
Cellular Component GO Annotation Evidence References Source
part of RNA polymerase II transcription regulator complex IDA
IDA: Inferred from direct assay
7739537 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TFDP2 Protein Structure

E2F_TDP

E2F_TDP: E2F/DP family winged-helix DNA-binding domain (127 - 208)

DP

DP: Transcription factor DP (215 - 355)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 446 a.a.
Protein Preferred Names Protein Names

transcription factor Dp-2

  • transcription factor Dp-2 (E2F dimerization partner 2)

Related Diseases

Diseases Alias
Retinoblastoma

  • RB

  • Trilateral Retinoblastoma

  • RB1

  • Retinoblastoma, Trilateral

  • Neuroblastoma Of Retina

  • Rb - Retinoblastoma

  • Eye Cancer, Retinoblastoma

  • Retinal Cancer

  • Retinal Tumor

  • Glioma, Retinal

  • Non-Hereditary Retinoblastoma

  • Childhood Cancer Retinoblastoma

  • Malignant Neoplasm Of Retina

  • Retinal Neoplasms
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14418 TFDP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22857 Tfdp2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29371 Tfdp2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus TFDP2 VGNC VGNC:66115
Canis familiaris TFDP2 VGNC VGNC:47292
Mus musculus TFDP2 MGD MGI:107167
Bos taurus TFDP2 VGNC VGNC:35786
Rattus norvegicus TFDP2 RGD RGD:1305814
Macaca mulatta TFDP2 VGNC VGNC:78324
Others TFDP2 NCBI