F13a1 - coagulation factor XIII, A1 subunit Gene

Also Known as F13a; 1200014I03Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 74145

Summary

This gene encodes subunit A of the coagulation factor XIII that catalyzes the final step of the blood coagulation pathway. The encoded protein associates with subunit B to form a heterotetrameric proenzyme that undergoes thrombin-mediated proteolysis to generate active factor XIIIa. The Transglutaminase activity of factor XIIIa is required for the calcium-dependent crosslinking of fibrin, leading to the formation of a clot. Mice lacking the encoded protein display impaired reproduction and reduced survival due to bleeding episodes, hematothorax, hematoperitoneum and subcutaneous hemorrhage. Additionally, mice lacking the encoded protein exhibit impaired wound healing and inadequate healing of myocardial infarction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

F13a1 Products (2)

mRNA Protein Name
NM_001166391.1 NP_001159863.1 coagulation factor XIII A chain
NM_028784.3 NP_083060.2 coagulation factor XIII A chain

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein-glutamine gamma-glutamyltransferase activity IMP
IMP: Inferred from mutant phenotype
12529747 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within blood coagulation IMP
IMP: Inferred from mutant phenotype
12529747 MGI
involved in blood coagulation, fibrin clot formation IMP
IMP: Inferred from mutant phenotype
18224415 MGI
acts upstream of or within peptide cross-linking IMP
IMP: Inferred from mutant phenotype
15507206 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

coagulation factor XIII A chain

  • coagulation factor XIII, alpha subunit

  • coagulation factor XIIIa

  • protein-glutamine gamma-glutamyltransferase A chain

  • transglutaminase A chain

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04628 F13A1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18275 F13a1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24753 F13a1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens F13a1 NCBI NCBI:2162