F13A1 - coagulation factor XIII A chain Gene

Also Known as F13A

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2162

About F13A1

Cytogenetic location: 6p25.1 Genomic coordinates (GRCh38): 6:6,144,084-6,320,662 (from NCBI)

This gene has 6 transcripts (splice variants), 291 orthologues, 8 paralogues and is associated with 4 phenotypes. Biased expression in placenta (RPKM 246.8), urinary bladder (RPKM 65.1) and 12 other tissues.

Summary

This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by Thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a Transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion. [provided by RefSeq, Jul 2008]

F13A1 Products (1)

mRNA	Protein	Name
NM_000129.4	NP_000120.2	coagulation factor XIII A chain

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32814053	GOA
enables protein-glutamine gamma-glutamyltransferase activity	IDA IDA: Inferred from direct assay	27363989	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in blood coagulation, fibrin clot formation	IDA IDA: Inferred from direct assay	27363989	GOA
involved in peptide cross-linking	IDA IDA: Inferred from direct assay	27363989	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

F13A1 Protein Structure

Transglut_N

Transglut_core

Transglut_C

0
200
400
600
732 a.a.

Protein Preferred Names	Protein Names
coagulation factor XIII A chain	FSF, A subunit

F13A1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	F13A1	P00488	WWOX	Homo sapiens	Q9NZC7-5	Validated Y2H	32814053
Intra	F13A1	P00488	WWOX	Homo sapiens	Q9NZC7-5	Y2H Array	32814053
Intra	F13A1	P00488	WWOX	Homo sapiens	Q9NZC7-5	Y2H Pooling	32814053
Intra	F13A1	P00488	IL16	Homo sapiens	Q14005-2	Y2H Array	32814053
Intra	F13A1	P00488	IL16	Homo sapiens	Q14005-2	Y2H Pooling	32814053
Intra	F13A1	P00488	IL16	Homo sapiens	Q14005-2	Validated Y2H	32814053
Intra	F13A1	P00488	CDCA4	Homo sapiens	Q9BXL8	Y2H Pooling	32814053
Intra	F13A1	P00488	CDCA4	Homo sapiens	Q9BXL8	Validated Y2H	32814053
Intra	F13A1	P00488	CDCA4	Homo sapiens	Q9BXL8	Y2H Array	32814053
Intra	F13A1	P00488	EGFL8	Homo sapiens	Q99944	Y2H Array	32814053
Intra	F13A1	P00488	KLHL20	Homo sapiens	Q9Y2M5	Validated Y2H	32814053
Intra	F13A1	P00488	KLHL20	Homo sapiens	Q9Y2M5	Y2H Pooling	32814053
Intra	F13A1	P00488	KLHL20	Homo sapiens	Q9Y2M5	Y2H Array	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant F13A1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70226	Coagulation factor XIII A/F13A Protein, Human (HEK293, His)	AAH27963.1 (G39-M732)	≥ 95%, as determined by reducing SDS-PAGE.

F13A1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81886	Factor XIIIa Antibody (YA1631)	WB, IHC-P	Human
HY-P81886A	Factor XIIIa Antibody (YA1631)(PBS only)	WB, IHC-P	Human
HY-P85912	Factor XIIIa Antibody (YA5604)	IHC-P, WB, ICC/IF, ELISA	Human, Mouse, Rat
HY-P86034	Factor XIIIa Antibody (YA5726)	IHC-P, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Factor Xiii, A Subunit, Deficiency Of	Factor Xiiia Deficiency Factor Xiii Subunit A Deficiency FA13AD F13 Deficiency Type 2 Type Ii F13 Deficiency
Thrombophilia Due To Thrombin Defect	Venous Thromboembolism Venous Thrombosis Thrombophilia Due To Factor 2 Defect Thromboembolism THPH1 Thromboembolism, Susceptibility To Venous Thromboembolism, Susceptibility To Venous Thrombosis, Protection Against Prothrombin-Related Thrombophilia Hyperprothrombinemia Venous Thrombosis, Susceptibility To Thrombophilia 1 Due To Thrombin Defect F2-Related Thrombophilia Factor Ii-Related Thrombophilia Prothrombin 20210g>A Thrombophilia Prothrombin G20210a Thrombophilia Prothrombin Thrombophilia
Factor Xiii Deficiency	Hereditary Factor Xiii Deficiency Disease Deficiency, Laki-Lorand Factor Congenital Factor Xiii Deficiency Fibrin Stabilizing Factor Deficiency Deficiency, Factor Xiii Factor Xiii Deficiency Disease Deficiency Of Factor Xiii Fibrin-Stabilizing Factor Deficiency Factor Xiii Deficiency, Congenital
Myocardial Infarction	Heart Attack Myocardial Infarction, Susceptibility To Myocardial Infarction 1 Myocardial Infarction, Protection Against Myocardial Infarction, Decreased Susceptibility To Myocardial Infarction, Decreased Myocardial Infarct MCI1 Premature Myocardial Infarction Myocardial Infarction, Susceptibility To, Type 1
Cutaneous Fibrous Histiocytoma	Dermatofibroma Fibrohistiocytic Tumor Benign Cutaneous Fibrous Histiocytoma Fibrous Histiocytoma Of Skin Fibrous Xanthoma Of Skin Pleomorphic Fibroma Sclerosing Angioma Sclerosing Angioma Of Skin Fibrous Histiocytoma
Granuloma Annulare	Granulome Annulare Ga - [Granuloma Annulare]
Fibrous Histiocytoma	Benign Fibrous Histiocytoma Histiocytoma, Benign Fibrous Fibroxanthoma Histiocytoma Fibrous
Xanthoma Disseminatum	Montgomery Syndrome
Dermatofibrosarcoma Protuberans	DFSP Dermatofibrosarcoma Giant Cell Fibroblastoma Metastatic Dermatofibrosarcoma Protuberans Familial Dermatofibrosarcoma Protuberans Darier-Ferrand Tumor Darier-Hoffmann Tumor
Juvenile Xanthogranuloma	Multiple Eruptive Juvenile Xanthogranuloma Naevoxanthoendothelioma Xanthoma Neviforme Xanthogranuloma, Juvenile
Thrombosis	Thrombosis Of Blood Vessel
Fibroma
Angiolipoma
Pulmonary Embolism	Pulmonary Artery Embolism Pulmonary Embolus Pulmonary Emboli
Neurofibroma	Neurofibromas Neurofibromatoses Nerve Sheath Tumors
Priapism	Mentulagra Priapism, Familial Idiopathic Familial Idiopathic Priapism Pathologic Erection Painful Erection
Malignant Fibrous Histiocytoma	Undifferentiated Pleomorphic Sarcoma Ups Histiocytoma, Malignant Fibrous Fibroxanthosarcoma Mfh Malignant Fibrohistiocytic Tumors Histiocytoma, Fibrous, Malignant
Langerhans Cell Histiocytosis	Histiocytosis X Lch Langerhans Cell Granulomatosis Langerhans-Cell Histiocytosis Letterer-Siwe Disease Hashimoto-Pritzger Disease Histiocytosis, Langerhans-Cell Langerhan'S Cell Histiocytosis Letterer-Siwe Disease Involving Intra-Abdominal Lymph Nodes Letterer-Siwe Disease Involving Intrapelvic Lymph Nodes Letterer-Siwe Disease Involving Intrathoracic Lymph Nodes Letterer-Siwe Disease Involving Lymph Nodes Of Axilla And Upper Limb Letterer-Siwe Disease Involving Lymph Nodes Of Head, Face And Neck Letterer-Siwe Disease Involving Lymph Nodes Of Head, Face, And Neck Letterer-Siwe Disease Involving Lymph Nodes Of Inguinal Region And Lower Limb Letterer-Siwe Disease Involving Lymph Nodes Of Multiple Sites Letterer-Siwe Disease Involving Spleen Letterer-Siwe Disease Of Intra-Abdominal Lymph Nodes Letterer-Siwe Disease Of Intrapelvic Lymph Nodes Letterer-Siwe Disease Of Intrathoracic Lymph Nodes Letterer-Siwe Disease Of Lymph Nodes Of Axilla And Upper Limb Letterer-Siwe Disease Of Lymph Nodes Of Axilla And/Or Upper Limb Letterer-Siwe Disease Of Lymph Nodes Of Head, Face And Neck Letterer-Siwe Disease Of Lymph Nodes Of Head, Face And/Or Neck Letterer-Siwe Disease Of Lymph Nodes Of Inguinal Region Amd/Or Lower Limb Letterer-Siwe Disease Of Lymph Nodes Of Inguinal Region And Lower Limb Letterer-Siwe Disease Of Lymph Nodes Of Inguinal Region And/Or Lower Limb Letterer-Siwe Disease Of Lymph Nodes Of Multiple Sites Letterer-Siwe Disease Of Spleen Familial Letterer-Siwe Disease Langerhans-Cell Histiocytosis Nos
Thrombophilia	Hypercoagulability State
Dysfibrinogenemia, Congenital	Dysfibrinogenemia Hypodysfibrinogenemia Familial Dysfibrinogenemia Familial Hypodysfibrinogenemia Hypodysfibrinogenemia, Congenital Dysfibrinogenemia, Familial Congenital Dysfibrinogenemia DYSFIBRIN
Hemangiopericytoma, Malignant	Hemangiopericytoma Haemangiopericytic Meningioma Malignant Hemangiopericytoma Solitary Fibrous Tumor
Cerebrovascular Disease	Cerebrovascular Disorder Cerebrovascular Accident Cerebrovascular Disorders Cva Stroke
Hemorrhagic Disease	Hemorrhagic Disorders Hemorrhagic Diathesis Hemorrhagic Diseases Bleeding Tendency Acquired Coagulation Factor Inhibitor Disorder Acquired Inhibitor Of Coagulation Antithrombinaemia Antithromboplastinogenaemia Circulating Anticoagulant Disorder Haemorrhagic Disorder Due To Antithrombinaemia Haemorrhagic Disorder Due To Excess Administered Heparin Antithromboplastinaemia Haemorrhagic Disorder Due To Hyperheparinemia
Dedifferentiated Liposarcoma	Ddls Liposarcoma Dedifferentiated Liposarcoma, Dedifferentiated
Castleman Disease	Angiofollicular Ganglionic Hyperplasia Angiofollicular Lymph Hyperplasia Giant Lymph Node Hyperplasia Castleman'S Disease Angiofollicular Lymph Node Hyperplasia Lymphoid Hamartoma Benign Giant Lymphoma Angiolymphoid Hyperplasia
Localized Scleroderma	Morphea Localised Scleroderma Localized Fibrosing Scleroderma Circumscribed Scleroderma Localised Morphea Localised Morphoea Localized Morphea Scleroderma, Circumscribed Or Localised Scleroderma, Circumscribed Or Localized Scleroderma, Localized
Pancytopenia
Basal Cell Carcinoma	Basal Cell Cancer Basal Cell Neoplasm Basal Cell Carcinoma Of Skin Malignant Basal Cell Tumor Basal Cell Tumor Epithelioma Basal Cell Malignant Basal Cell Neoplasm Rodent Ulcer Carcinoma Basal Cell Neoplasms, Basal Cell Basal Cell Carcinomas Experimental Organism Basal Cell Carcinoma Nodulo-Ulcerative Basal Cell Carcinoma Basalioma Basal Cell Epithelioma Of Skin Bcc - [Basal Cell Carcinoma] Of Skin Rodent Ulcer Of Skin Rodent Ulcer Of Unspecified Site Basal Cell Epithelioma Of Unspecified Site
Skin Disease	Skin Diseases Genodermatosis Abnormality Of The Skin Skin Diseases, Genetic Skin And Subcutaneous Tissue Disease Dermatologic Disorders

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04628	F13A1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18275	F13a1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24753	F13a1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	F13A1	VGNC	VGNC:28680
Mus musculus	F13A1	MGD	MGI:1921395
Canis familiaris	F13A1	VGNC	VGNC:40545
Macaca mulatta	F13A1	VGNC	VGNC:72462
Rattus norvegicus	F13A1	RGD	RGD:621495
Felis catus	F13A1	VGNC	VGNC:62021
Others	F13A1	NCBI