Hopx - HOP homeobox Gene

Also Known as Hod; Hop; Ob1; Obl; Hdop; Toto; Cameo; 1110018K11Rik; 1200015P04Rik; 2300002F06Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 74318

Summary

Predicted to enable DNA binding activity. Acts upstream of or within several processes, including lung alveolus development; positive regulation of skeletal muscle tissue regeneration; and trophectodermal cell differentiation. Located in nucleus. Is expressed in several structures, including central nervous system; heart; nose; trophectoderm; and urinary system. Orthologous to human HOPX (HOP homeobox). [provided by Alliance of Genome Resources, Apr 2022]

Hopx Products (3)

mRNA Protein Name
NM_001159900.1 NP_001153372.1 homeodomain-only protein
NM_001159901.1 NP_001153373.1 homeodomain-only protein
NM_175606.3 NP_783199.1 homeodomain-only protein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables histone deacetylase regulator activity IGI
IGI: Inferred from genetic interaction
12975471 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
12297046 MGI
NOT enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
12297045 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within heart development IMP
IMP: Inferred from mutant phenotype
12297045 MGI
acts upstream of or within lung alveolus development IMP
IMP: Inferred from mutant phenotype
16510470 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
12297045 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
17409236 MGI
involved in positive regulation of gap junction assembly IMP
IMP: Inferred from mutant phenotype
15790958 MGI
acts upstream of or within positive regulation of skeletal muscle tissue regeneration IMP
IMP: Inferred from mutant phenotype
17192267 MGI
acts upstream of or within positive regulation of striated muscle cell differentiation IMP
IMP: Inferred from mutant phenotype
17192267 MGI
acts upstream of or within regulation of heart contraction IMP
IMP: Inferred from mutant phenotype
15790958 MGI
acts upstream of or within regulation of protein binding IDA
IDA: Inferred from direct assay
20833366 MGI
acts upstream of or within trophectodermal cell differentiation IMP
IMP: Inferred from mutant phenotype
17576768 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
12297045 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

homeodomain-only protein

  • homeobox only domain

  • homeobox-only protein

  • mOB1

  • odd homeobox 1

  • odd homeobox protein 1

Hopx Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Hopx Q8R1H0 Smad4 Mus musculus P97471
Anti Tag CoIP
26113728
Cross: Cross-species interaction Intra: Intraspecies interaction

Hopx Antibodies

Cat. No. Product Name Application Reactivity
HY-P80979 HOPX Antibody (YA846) WB, IP Human
HY-P80979A HOPX Antibody (YA846)(PBS only) WB, IP Human

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06290 HOPX Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20288 Hopx Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26796 Hopx Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hopx NCBI NCBI:84525