1. Gene
  2. XPNPEP1 - X-prolyl aminopeptidase 1 Gene

XPNPEP1 - X-prolyl aminopeptidase 1 Gene

Homo sapiens

Also known as APP1; SAMP; XPNPEP; XPNPEPL; XPNPEPL1

Gene ID: 7511 | Gene type: protein coding

About XPNPEP1

Cytogenetic location: 10q25.1 Genomic coordinates (GRCh38): 10:109,864,766-109,923,511 (from NCBI)

This gene has 29 transcripts (splice variants), 213 orthologues and 7 paralogues. Ubiquitous expression in small intestine (RPKM 32.0), duodenum (RPKM 25.3) and 25 other tissues.

Summary

This gene encodes the cytosolic form of a metalloaminopeptidase that catalyzes the cleavage of the N-terminal amino acid adjacent to a proline residue. The gene product may play a role in degradation and maturation of tachykinins, neuropeptides, and peptide Hormones. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Nov 2009]

XPNPEP1 Products(9)

mRNA Protein Name
NM_001167604.2 NP_001161076.1 xaa-Pro aminopeptidase 1 isoform 2
NM_001324128.2 NP_001311057.1 xaa-Pro aminopeptidase 1 isoform 3
NM_001324131.2 NP_001311060.1 xaa-Pro aminopeptidase 1 isoform 4
NM_001324132.2 NP_001311061.1 xaa-Pro aminopeptidase 1 isoform 5
NM_001324133.2 NP_001311062.1 xaa-Pro aminopeptidase 1 isoform 6
NM_001324134.2 NP_001311063.1 xaa-Pro aminopeptidase 1 isoform 7
NM_001324135.2 NP_001311064.1 xaa-Pro aminopeptidase 1 isoform 8
NM_001324136.1 NP_001311065.1 xaa-Pro aminopeptidase 1 isoform 9
NM_020383.4 NP_065116.3 xaa-Pro aminopeptidase 1 isoform 1

XPNPEP1 Protein Structure

Creatinase_N

Creatinase_N: Creatinase/Prolidase N-terminal domain (55 - 191)

Peptidase_M24

Peptidase_M24: Metallopeptidase family M24 (371 - 585)

  • 0
  • 200
  • 400
  • 600
  • 666 a.a.
Protein Preferred Names Protein Names

xaa-Pro aminopeptidase 1

X-Pro aminopeptidase 1

Recombinant XPNPEP1 Proteins

Cat. No. Product Name Accession Purity
HY-P7498 Aminopeptidase P1 Protein, Human (His) Q9NQW7 (P2-Q622) ≥95%
HY-P700260 Aminopeptidase P1 Protein, Human (His-SUMO) Q9NQW7 (P2-Q623) ≥95%

Related Diseases

Diseases Alias
Biliary Atresia

Congenital Biliary Atresia

Isolated Biliary Atresia

Isolated Atresia Of Bile Ducts

Non-Syndromic Biliary Atresia

Atresia Of Bile Duct

Biliary Atresia, Congenital

Atresia Of Bile Ducts

Bile Duct Atresia

Congenital Bile Duct Atresia

Ba - [Biliary Atresia]

Impervious Bile Duct

Atresia Of Common Duct

Biliary Duct Atresia

Bile Ductal Atresia

Cystic Duct Atresia

Chicken Egg Allergy

Gallus Gallus Egg Allergy

Mature Cataract

Total Or Mature Cataract

Total, Mature Senile Cataract

Granulomatous Disease, Chronic, Autosomal Recessive, 1

Chronic Granulomatous Disease Due To Deficiency Of Ncf-1

CGD1

Ncf1 Deficiency

Soluble Oxidase Component Ii Deficiency

Soc2 Deficiency

P47-Phox Deficiency

Autosomal Recessive Chronic Granulomatous Disease Cytochrome B-Positive Type I

Deficiency Of Neutrophil Cytosol Factor 1

Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-Positive, Type 1

Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-Positive, Type I

Cgd, Autosomal Recessive Cytochrome B-Positive, Type I

Granulomatous Disease, Chronic, Due To Ncf1 Deficiency

Neutrophil Cytosol Factor 1 Deficiency

Chronic Granulomatous Disease 1, Autosomal Recessive

Autosomal Recessive Chronic Granulomatous Disease 1

Cdg1

Deficiency Of Ncf1

Deficiency Of P47-Phox

Deficiency Of Soc2

Deficiency Of Soluble Oxidase Component Ii

Chronic Granulomatous Disease Autosomal Recessive Cytochrome B-Positive Type I

Chronic Granulomatous Disease Due To Ncf1 Deficiency

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Felis catus XPNPEP1 VGNC VGNC:67110
Rattus norvegicus XPNPEP1 RGD RGD:621274
Canis familiaris XPNPEP1 VGNC VGNC:48457
Macaca mulatta XPNPEP1 VGNC VGNC:78810
Mus musculus XPNPEP1 MGD MGI:2180003
Bos taurus XPNPEP1 VGNC VGNC:36994
Others XPNPEP1 NCBI