XPNPEP1 - X-prolyl aminopeptidase 1 Gene

Also Known as APP1; SAMP; XPNPEP; XPNPEPL; XPNPEPL1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 7511

About XPNPEP1

Cytogenetic location: 10q25.1 Genomic coordinates (GRCh38): 10:109,864,766-109,923,511 (from NCBI)

This gene has 29 transcripts (splice variants), 213 orthologues and 7 paralogues. Ubiquitous expression in small intestine (RPKM 32.0), duodenum (RPKM 25.3) and 25 other tissues.

Summary

This gene encodes the cytosolic form of a metalloaminopeptidase that catalyzes the cleavage of the N-terminal amino acid adjacent to a proline residue. The gene product may play a role in degradation and maturation of tachykinins, neuropeptides, and peptide Hormones. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Nov 2009]

XPNPEP1 Products (9)

mRNA Protein Name
NM_001167604.2 NP_001161076.1 xaa-Pro aminopeptidase 1 isoform 2
NM_001324128.2 NP_001311057.1 xaa-Pro aminopeptidase 1 isoform 3
NM_001324131.2 NP_001311060.1 xaa-Pro aminopeptidase 1 isoform 4
NM_001324132.2 NP_001311061.1 xaa-Pro aminopeptidase 1 isoform 5
NM_001324133.2 NP_001311062.1 xaa-Pro aminopeptidase 1 isoform 6
NM_001324134.2 NP_001311063.1 xaa-Pro aminopeptidase 1 isoform 7
NM_001324135.2 NP_001311064.1 xaa-Pro aminopeptidase 1 isoform 8
NM_001324136.1 NP_001311065.1 xaa-Pro aminopeptidase 1 isoform 9
NM_020383.4 NP_065116.3 xaa-Pro aminopeptidase 1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables aminopeptidase activity IDA
IDA: Inferred from direct assay
11106490 GOA
enables manganese ion binding IDA
IDA: Inferred from direct assay
18515364 GOA
enables metalloaminopeptidase activity IDA
IDA: Inferred from direct assay
18515364 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables protein homodimerization activity IPI
IPI: Inferred from physical interaction
18515364 GOA
Biological Process GO Annotation Evidence References Source
involved in bradykinin catabolic process IDA
IDA: Inferred from direct assay
18515364 GOA
involved in negative regulation of programmed cell death IDA
IDA: Inferred from direct assay
35165443 GOA
involved in proteolysis IDA
IDA: Inferred from direct assay
11106490 GOA
Cellular Component GO Annotation Evidence References Source
is active in cytosol IDA
IDA: Inferred from direct assay
11106490 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

XPNPEP1 Protein Structure

Creatinase_N

Creatinase_N: Creatinase/Prolidase N-terminal domain (55 - 191)

Peptidase_M24

Peptidase_M24: Metallopeptidase family M24 (371 - 585)

  • 0
  • 200
  • 400
  • 600
  • 666 a.a.
Protein Preferred Names Protein Names

xaa-Pro aminopeptidase 1

  • X-Pro aminopeptidase 1

Recombinant XPNPEP1 Proteins

Cat. No. Product Name Accession Purity
HY-P7498 Aminopeptidase P1 Protein, Human (His) Q9NQW7 (P2-Q622) ≥ 85%, as determined by reducing SDS-PAGE.
HY-P700260 Aminopeptidase P1 Protein, Human (His-SUMO) Q9NQW7 (P2-H623) ≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Biliary Atresia

  • Congenital Biliary Atresia

  • Isolated Biliary Atresia

  • Isolated Atresia Of Bile Ducts

  • Non-Syndromic Biliary Atresia

  • Atresia Of Bile Duct

  • Biliary Atresia, Congenital

  • Atresia Of Bile Ducts

  • Bile Duct Atresia

  • Congenital Bile Duct Atresia

  • Ba - [Biliary Atresia]

  • Impervious Bile Duct

  • Atresia Of Common Duct

  • Biliary Duct Atresia

  • Bile Ductal Atresia

  • Cystic Duct Atresia
Chicken Egg Allergy

  • Gallus Gallus Egg Allergy
Mature Cataract

  • Total Or Mature Cataract

  • Total, Mature Senile Cataract
Granulomatous Disease, Chronic, Autosomal Recessive, 1

  • Chronic Granulomatous Disease Due To Deficiency Of Ncf-1

  • CGD1

  • Ncf1 Deficiency

  • Soluble Oxidase Component Ii Deficiency

  • Soc2 Deficiency

  • P47-Phox Deficiency

  • Autosomal Recessive Chronic Granulomatous Disease Cytochrome B-Positive Type I

  • Deficiency Of Neutrophil Cytosol Factor 1

  • Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-Positive, Type 1

  • Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-Positive, Type I

  • Cgd, Autosomal Recessive Cytochrome B-Positive, Type I

  • Granulomatous Disease, Chronic, Due To Ncf1 Deficiency

  • Neutrophil Cytosol Factor 1 Deficiency

  • Chronic Granulomatous Disease 1, Autosomal Recessive

  • Autosomal Recessive Chronic Granulomatous Disease 1

  • Cdg1

  • Deficiency Of Ncf1

  • Deficiency Of P47-Phox

  • Deficiency Of Soc2

  • Deficiency Of Soluble Oxidase Component Ii

  • Chronic Granulomatous Disease Autosomal Recessive Cytochrome B-Positive Type I

  • Chronic Granulomatous Disease Due To Ncf1 Deficiency
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-183739 CQ31 / Unkown
HY-185207 CQ80 Inducer / Unkown
HY-RS15886 XPNPEP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19557 Xpnpep1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26053 Xpnpep1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus XPNPEP1 VGNC VGNC:67110
Rattus norvegicus XPNPEP1 RGD RGD:621274
Canis familiaris XPNPEP1 VGNC VGNC:48457
Macaca mulatta XPNPEP1 VGNC VGNC:78810
Mus musculus XPNPEP1 MGD MGI:2180003
Bos taurus XPNPEP1 VGNC VGNC:36994
Others XPNPEP1 NCBI