2. Gene
  3. CENPM - centromere protein M Gene

CENPM - centromere protein M Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as PANE1; CENP-M; C22orf18

Gene ID: 79019 | Gene type: protein coding

About CENPM

Cytogenetic location: 22q13.2 Genomic coordinates (GRCh38): 22:41,927,196-41,947,152 (from NCBI)

This gene has 8 transcripts (splice variants) and 195 orthologues. Broad expression in bone marrow (RPKM 4.2), lymph node (RPKM 4.2) and 15 other tissues.

Summary

The protein encoded by this gene is an inner protein of the kinetochore, the multi-protein complex that binds spindle microtubules to regulate chromosome segregation during cell division. It belongs to the constitutive centromere-associated network protein group, whose members interact with outer kinetochore proteins and help to maintain centromere identity at each cell division cycle. The protein is structurally related to GTPases but cannot bind guanosine triphosphate. A point mutation that affects interaction with another constitutive centromere-associated network protein, CENP-I, impairs kinetochore assembly and chromosome alignment, suggesting that it is required for kinetochore formation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

CENPM Products(7)

mRNA Protein Name
NM_001002876.3 NP_001002876.1 centromere protein M isoform b
NM_001110215.3 NP_001103685.1 centromere protein M isoform c
NM_001304370.2 NP_001291299.1 centromere protein M isoform d
NM_001304371.2 NP_001291300.1 centromere protein M isoform e
NM_001304372.2 NP_001291301.1 centromere protein M isoform f
NM_001304373.2 NP_001291302.1 centromere protein M isoform g
NM_024053.5 NP_076958.1 centromere protein M isoform a

CENPM Protein Structure

CENP-M

CENP-M: Centromere protein M (CENP-M) (1 - 173)

  • 0
  • 100
  • 180 a.a.
Protein Preferred Names Protein Names

centromere protein M

interphase centromere complex protein 39

Related Diseases

Diseases Alias
Chromosome 17p13.3, Centromeric, Duplication Syndrome

Chromosome 17p13.3 Duplication Syndrome

17p13.3 Duplication Syndrome

17p13.3 Microduplication Syndrome

Trisomy 17p13.3

Chromosome 17p13.3 Centromeric Duplication Syndrome

Dup(17)(P13.3)
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS02485 CENPM Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus CENPM RGD RGD:1307309
Bos taurus CENPM VGNC VGNC:27181
Felis catus CENPM VGNC VGNC:60758
Macaca mulatta CENPM VGNC VGNC:71001
Mus musculus CENPM MGD MGI:1913820
Canis familiaris CENPM VGNC VGNC:39108