PARP9 - poly(ADP-ribose) polymerase family member 9 Gene

Also Known as BAL; BAL1; ARTD9; MGC:7868

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 83666

About PARP9

Cytogenetic location: 3q21.1 Genomic coordinates (GRCh38): 3:122,527,924-122,564,784 (from NCBI)

This gene has 8 transcripts (splice variants), 250 orthologues and 8 paralogues. Ubiquitous expression in spleen (RPKM 10.3), appendix (RPKM 10.1) and 25 other tissues.

Summary

Enables several functions, including ADP-D-ribose binding activity; NAD+ ADP-ribosyltransferase activity; and STAT family protein binding activity. Involved in several processes, including positive regulation of nitrogen compound metabolic process; regulation of defense response; and regulation of gene expression. Located in several cellular components, including mitochondrion; nucleoplasm; and site of DNA damage. Part of protein-containing complex. Colocalizes with nucleus. [provided by Alliance of Genome Resources, Apr 2022]

PARP9 Products (23)

mRNA	Protein	Name
NM_001146102.2	NP_001139574.1	protein mono-ADP-ribosyltransferase PARP9 isoform a
NM_001146103.2	NP_001139575.1	protein mono-ADP-ribosyltransferase PARP9 isoform b
NM_001146104.2	NP_001139576.1	protein mono-ADP-ribosyltransferase PARP9 isoform b
NM_001146105.2	NP_001139577.1	protein mono-ADP-ribosyltransferase PARP9 isoform b
NM_001146106.3	NP_001139578.1	protein mono-ADP-ribosyltransferase PARP9 isoform c
NM_001387871.1	NP_001374800.1	protein mono-ADP-ribosyltransferase PARP9 isoform a
NM_001387872.1	NP_001374801.1	protein mono-ADP-ribosyltransferase PARP9 isoform a
NM_001387873.1	NP_001374802.1	protein mono-ADP-ribosyltransferase PARP9 isoform d
NM_001387874.1	NP_001374803.1	protein mono-ADP-ribosyltransferase PARP9 isoform d
NM_001387875.1	NP_001374804.1	protein mono-ADP-ribosyltransferase PARP9 isoform b
NM_001387876.1	NP_001374805.1	protein mono-ADP-ribosyltransferase PARP9 isoform b
NM_001387877.1	NP_001374806.1	protein mono-ADP-ribosyltransferase PARP9 isoform b
NM_001387878.1	NP_001374807.1	protein mono-ADP-ribosyltransferase PARP9 isoform e
NM_001387879.1	NP_001374808.1	protein mono-ADP-ribosyltransferase PARP9 isoform e
NM_001387880.1	NP_001374809.1	protein mono-ADP-ribosyltransferase PARP9 isoform f
NM_001387881.1	NP_001374810.1	protein mono-ADP-ribosyltransferase PARP9 isoform g
NM_001387882.1	NP_001374811.1	protein mono-ADP-ribosyltransferase PARP9 isoform g
NM_001387883.1	NP_001374812.1	protein mono-ADP-ribosyltransferase PARP9 isoform g
NM_001387884.1	NP_001374813.1	protein mono-ADP-ribosyltransferase PARP9 isoform g
NM_001387885.1	NP_001374814.1	protein mono-ADP-ribosyltransferase PARP9 isoform c
NM_001387886.1	NP_001374815.1	protein mono-ADP-ribosyltransferase PARP9 isoform c
NM_001387887.1	NP_001374816.1	protein mono-ADP-ribosyltransferase PARP9 isoform c
NM_031458.3	NP_113646.2	protein mono-ADP-ribosyltransferase PARP9 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ADP-D-ribose binding	IMP IMP: Inferred from mutant phenotype	26479788	GOA
NOT enables NAD+ binding	IMP IMP: Inferred from mutant phenotype	16061477	GOA
enables NAD+-protein poly-ADP-ribosyltransferase activity	IDA IDA: Inferred from direct assay	23230272	GOA
NOT enables NAD+-protein poly-ADP-ribosyltransferase activity	IMP IMP: Inferred from mutant phenotype	16061477	GOA
enables NAD+-protein-C-terminal glycine ADP-ribosyltransferase activity	IDA IDA: Inferred from direct assay	28525742	GOA
enables STAT family protein binding	IPI IPI: Inferred from physical interaction	26479788	GOA
enables enzyme binding	IPI IPI: Inferred from physical interaction	27796300	GOA
enables enzyme inhibitor activity	IDA IDA: Inferred from direct assay	27796300	GOA
enables histone binding	IPI IPI: Inferred from physical interaction	26479788	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16809771	GOA
enables transcription corepressor activity	IMP IMP: Inferred from mutant phenotype	16061477	GOA
enables ubiquitin-like protein ligase binding	IPI IPI: Inferred from physical interaction	28525742	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in DNA damage checkpoint signaling	IMP IMP: Inferred from mutant phenotype	28525742	GOA
involved in double-strand break repair	IMP IMP: Inferred from mutant phenotype	23230272	GOA
involved in negative regulation of catalytic activity	IDA IDA: Inferred from direct assay	27796300	GOA
involved in negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	27796300	GOA
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	16061477	GOA
involved in positive regulation of DNA-templated transcription	IGI IGI: Inferred from genetic interaction	26479788	GOA
involved in positive regulation of chromatin binding	IGI IGI: Inferred from genetic interaction	26479788	GOA
involved in positive regulation of defense response to virus by host	IGI IGI: Inferred from genetic interaction	26479788	GOA
involved in positive regulation of protein localization to nucleus	IGI IGI: Inferred from genetic interaction	26479788	GOA
involved in positive regulation of type II interferon-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	27796300	GOA
involved in positive regulation of tyrosine phosphorylation of STAT protein	IMP IMP: Inferred from mutant phenotype	27796300	GOA
involved in post-transcriptional regulation of gene expression	IMP IMP: Inferred from mutant phenotype	26479788	GOA
NOT involved in protein poly-ADP-ribosylation	IMP IMP: Inferred from mutant phenotype	16061477	GOA
involved in regulation of response to type II interferon	IDA IDA: Inferred from direct assay	16809771	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	16809771	GOA
colocalizes with nucleus	IDA IDA: Inferred from direct assay	26479788	GOA
located in nucleus	IDA IDA: Inferred from direct assay	16809771	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	26479788	GOA
located in site of DNA damage	IDA IDA: Inferred from direct assay	28525742	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PARP9 Protein Structure

Macro

0
200
400
600
800
854 a.a.

Protein Preferred Names	Protein Names
protein mono-ADP-ribosyltransferase PARP9	ADP-ribosyltransferase diphtheria toxin-like 9

Related Diseases

Diseases	Alias
Lymphoma	Lymphoid Cancer Lymphomas Lymphoid Cancers Lymphoid Neoplasm Lymphoma Nos Nhl - [Non-Hodgkin Lymphoma] Non-Hodgkin Lymphoma Non-Hodgkin Lymphoma, Nos Non-Hodgkin Malignant Lymphoma Nos
B-Cell Lymphoma	Lymphoma, B-Cell B-Cell Lymphomas B-Cell Lymphocytic Neoplasm Lymphoma B-Cell B-Cell Lymphoma Nos
Osebold-Remondini Syndrome	Brachydactyly Type A6 Brachymesophalangy With Mesomelic Short Limbs And Carpal And Tarsal Osseous Abnormalities Bda6 Brachydactyly, Type A6
Arthrogryposis, Renal Dysfunction, And Cholestasis 1	Arc Syndrome ARCS1 Arthrogryposis Renal Dysfunction Cholestasis Syndrome Arthrogryposis-Renal Dysfunction-Cholestasis Syndrome Arcs Arthrogryposis, Renal Dysfunction And Cholestasis Syndrome Arthrogryposis, Renal Dysfunction, And Cholestasis Arthrogryposis-Renal Dysfunction-Cholestasis Arthrogryposis - Renal Dysfunction - Cholestasis Arthrogryposis Multiplex Congenita, Renal Dysfunction, And Cholestasis Arthrogryposis, Renal Dysfunction And Cholestasis Syndrome 1 Arthrogryposis Renal Dysfunction And Cholestasis 1 Arthrogryposis With Renal Dysfunction And Cholestasis Syndrome Arthrogryposis, Renal Dysfunction, Cholestasis, Type 1 Kidney Failure Renal Insufficiency

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	상품명	효과	Purity	Rare Diseases
HY-146248	TFMU-ADPr		/	Unkown
HY-170942	CDK9/PARP-IN-1	Inhibitor	/	Unkown
HY-RS10071	PARP9 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20074	Parp9 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26577	Parp9 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PARP9	RGD	RGD:1307534
Mus musculus	PARP9	MGD	MGI:1933117
Macaca mulatta	PARP9	VGNC	VGNC:84057
Bos taurus	PARP9	VGNC	VGNC:53596
Felis catus	PARP9	VGNC	VGNC:102799
Canis familiaris	PARP9	VGNC	VGNC:53084
Others	PARP9	NCBI