CDCA7 - cell division cycle associated 7 Gene

Also Known as ICF3; JPO1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 83879

About CDCA7

Cytogenetic location: 2q31.1 Genomic coordinates (GRCh38): 2:173,354,872-173,368,997 (from NCBI)

This gene has 14 transcripts (splice variants), 218 orthologues, 1 paralogue and is associated with 2 phenotypes. Broad expression in lymph node (RPKM 15.2), duodenum (RPKM 15.1) and 14 other tissues.

Summary

This gene was identified as a c-Myc responsive gene, and behaves as a direct c-Myc target gene. Overexpression of this gene is found to enhance the transformation of lymphoblastoid cells, and it complements a transformation-defective Myc Box II mutant, suggesting its involvement in c-Myc-mediated cell transformation. Two alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

CDCA7 Products (2)

mRNA	Protein	Name
NM_031942.5	NP_114148.3	cell division cycle-associated protein 7 isoform 1
NM_145810.3	NP_665809.1	cell division cycle-associated protein 7 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32814053	GOA

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within regulation of cell population proliferation	IDA IDA: Inferred from direct assay	11598121	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	11598121	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CDCA7 Protein Structure

zf-4CXXC_R1

0
100
200
300
371 a.a.

Protein Preferred Names	Protein Names
cell division cycle-associated protein 7	c-Myc target JPO1

CDCA7 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CDCA7	Q9BWT1	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	CDCA7	Q9BWT1	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
Intra	CDCA7	Q9BWT1	WFS1	Homo sapiens	O76024	Y2H Array	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Immunodeficiency-Centromeric Instability-Facial Anomalies Syndrome 3	ICF3 Icf Syndrome 3 Immunodeficiency-Centromeric Instability-Facial Anomalies Syndrome, Type 3
Immunodeficiency-Centromeric Instability-Facial Anomalies Syndrome	Icf Syndrome Immunodeficiency Syndrome, Variable Ciid Centromeric Instability, Immunodeficiency Syndrome Immune Deficiency, Variable, With Centromeric Instability Of Chromosomes 1, 9, And 16 Icf
Immunodeficiency-Centromeric Instability-Facial Anomalies Syndrome 1	Immunodeficiency Syndrome, Variable ICF1 Ciid Immune Deficiency, Variable, With Centromeric Instability Of Chromosomes 1, 9, And 16 Centromeric Instability, Immunodeficiency Syndrome Icf Syndrome 1 Centromeric Instability Immunodeficiency Syndrome Icf Syndrome Variable Immune Deficiency With Centromeric Instability Of Chromosomes 1 9 And 16 Variable Immunodeficiency Syndrome Immunodeficiency-Centromeric Instability-Facial Anomalies Syndrome, Type 1 Common Variable Immunodeficiency Chromosomal Instability
Hepatic Venoocclusive Disease With Immunodeficiency	VODI Hepatic Veno-Occlusive Disease-Immunodeficiency Syndrome Hepatic Veno-Occlusive Disease With Immunodeficiency Familial Veno-Occlusive Disease With Immunodeficiency Veno-Occlusive Disease And Immunodeficiency Syndrome Vodi Syndrome Vodi - [Veno-Occlusive Disease Immunodeficiency] Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02315	CDCA7 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS02316	CDCA7L Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20372	Cdca7 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26882	Cdca7 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CDCA7	RGD	RGD:1309363
Macaca mulatta	CDCA7	VGNC	VGNC:70713
Bos taurus	CDCA7	VGNC	VGNC:27086
Mus musculus	CDCA7	MGD	MGI:1914203
Felis catus	CDCA7	VGNC	VGNC:60668
Others	CDCA7	NCBI