PLXDC2 - plexin domain containing 2 Gene

Also Known as TEM7R

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 84898

About PLXDC2

Cytogenetic location: 10p12.31 Genomic coordinates (GRCh38): 10:19,816,432-20,289,856 (from NCBI)

This gene has 3 transcripts (splice variants), 253 orthologues and 1 paralogue. Ubiquitous expression in gall bladder (RPKM 10.7), lung (RPKM 7.5) and 24 other tissues.

Summary

Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]

PLXDC2 Products (2)

mRNA Protein Name
NM_001282736.2 NP_001269665.1 plexin domain-containing protein 2 isoform 2
NM_032812.9 NP_116201.7 plexin domain-containing protein 2 isoform 1 precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
15574754 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PLXDC2 Protein Structure

PSI

PSI: Plexin repeat (327 - 372)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 529 a.a.
Protein Preferred Names Protein Names

plexin domain-containing protein 2

  • 1200007L24Rik

PLXDC2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
PLXDC2 Q6UX71 Zbp1 Mus musculus A2APF7
Anti Tag CoIP
21903422
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PLXDC2 Proteins

Cat. No. Product Name Accession Purity
HY-P700832 PLXDC2 Protein, Human (HEK293, His) Q6UX71-1 (K31-A454) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Vulva Squamous Cell Carcinoma

  • Squamous Cell Carcinoma Of Vulva

  • Vulvar Squamous Cell Carcinoma

  • Vulvar Epidermoid Carcinoma

  • Squamous Cell Carcinoma Of The Vulva
Glaucoma, Primary Open Angle

  • Glaucoma 1, Open Angle, E

  • Primary Open Angle Glaucoma

  • POAG

  • Adult-Onset Primary Open Angle Glaucoma

  • Chronic Simple Glaucoma

  • GLC1E

  • Primary Open Angle Glaucoma 1e

  • Glaucoma, Open Angle, Primary
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10747 PLXDC2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18010 Plxdc2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24483 Plxdc2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990516 Anti-TEM7R/PLXDC2 Antibody Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus PLXDC2 VGNC VGNC:33058
Mus musculus PLXDC2 MGD MGI:1914698
Macaca mulatta PLXDC2 VGNC VGNC:76088
Canis familiaris PLXDC2 VGNC VGNC:44717
Rattus norvegicus PLXDC2 RGD RGD:1305962
Felis catus PLXDC2 VGNC VGNC:64251
Others PLXDC2 NCBI