RELT - RELT TNF receptor Gene

Also Known as AI3C; TRLT; TNFRSF19L

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 84957

About RELT

Cytogenetic location: 11q13.4 Genomic coordinates (GRCh38): 11:73,376,399-73,397,474 (from NCBI)

This gene has 7 transcripts (splice variants), 197 orthologues, 21 paralogues and is associated with 2 phenotypes. Biased expression in bone marrow (RPKM 25.4), spleen (RPKM 6.1) and 8 other tissues.

Summary

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is especially abundant in hematologic tissues. It has been shown to activate the NF-kappaB pathway and selectively bind TNF receptor-associated factor 1 (TRAF1). This receptor is capable of stimulating T-cell proliferation in the presence of CD3 signaling, which suggests its regulatory role in immune response. Two alternatively spliced transcript variants of this gene encoding the same protein have been reported. [provided by RefSeq, Jul 2008]

RELT Products (2)

mRNA	Protein	Name
NM_032871.4	NP_116260.2	tumor necrosis factor receptor superfamily member 19L precursor
NM_152222.2	NP_689408.1	tumor necrosis factor receptor superfamily member 19L precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16530727	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in amelogenesis	IMP IMP: Inferred from mutant phenotype	30506946	GOA
involved in apoptotic process	IMP IMP: Inferred from mutant phenotype	16530727	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RELT Protein Structure

RELT

0
100
200
300
400
430 a.a.

Protein Preferred Names	Protein Names
tumor necrosis factor receptor superfamily member 19L	RELT tumor necrosis factor receptor

Recombinant RELT Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71258	RELT Protein, Human (HEK293, Fc)	Q969Z4 (S26-A160)	≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Amelogenesis Imperfecta, Type Iiic	AI3C Amelogenesis Imperfecta, Hypocalcification Type, Autosomal Recessive Amelogenesis Imperfecta Type 3c Amelogenesis Imperfecta, Type 3c Amelogenesis Imperfecta Type Iiic Autosomal Recessive Amelogenesis Imperfecta Hypocalcification Type Amelogenesis Imperfecta 3c
Hypoplastic Amelogenesis Imperfecta	Amelogenesis Imperfecta Type 1 Amelogenesis Imperfecta, Hypoplastic Type Amelogenesis Imperfecta Local Hypoplastic Form
Amelogenesis Imperfecta	Ai Congenital Enamel Hypoplasia Al - [Amelogenesis Imperfecta]
Myopathy, Congenital, Compton-North	Compton-North Congenital Myopathy MYPCN Congenital Lethal Myopathy, Compton-North Type
Amelogenesis Imperfecta, Hypomaturation Type, Iia5	Amelogenesis Imperfecta Hypomaturation Type 2a5 AI2A5 Amelogenesis Imperfecta, Type Iia5 Amelogenesis Imperfecta Hypomaturation Type Iia5 Amelogenesis Imperfecta Type Iia5 Amelogenesis Imperfecta, Hypomaturation Type, 2a5

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11836	RELT Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18969	Relt Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25459	Relt Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	RELT	VGNC	VGNC:64568
Rattus norvegicus	RELT	RGD	RGD:1305381
Bos taurus	RELT	VGNC	VGNC:33862
Canis familiaris	RELT	VGNC	VGNC:45471
Mus musculus	RELT	MGD	MGI:2443373
Macaca mulatta	RELT	VGNC	VGNC:76728
Others	RELT	NCBI