Folh1 - folate hydrolase 1 Gene

Also Known as Naalad

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 85309

Summary

Predicted to enable Ac-Asp-Glu binding activity; exopeptidase activity; and tetrahydrofolyl-poly(glutamate) polymer binding activity. Involved in positive regulation of apoptotic process and proteolysis. Predicted to be located in cell surface. Predicted to be integral component of plasma membrane. Predicted to be active in plasma membrane. Orthologous to several human genes including FOLH1 (folate hydrolase 1). [provided by Alliance of Genome Resources, Apr 2022]

Folh1 Products (1)

mRNA Protein Name
NM_057185.3 NP_476533.2 glutamate carboxypeptidase 2

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in positive regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
12876198 RGD
involved in protein catabolic process IDA
IDA: Inferred from direct assay
9501243 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

glutamate carboxypeptidase 2

  • FGCP

  • GCPII

  • N-acetylated alpha-linked acidic dipeptidase

  • N-acetylated-alpha-linked acidic dipeptidase I

  • NAALADase I

  • folylpoly-gamma-glutamate carboxypeptidase

  • glutamate carboxypeptidase II

  • mGCP

  • membrane glutamate carboxypeptidase

  • prostate-specific

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive MoleculesInhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Phase
HY-P991708 Olsutamig Inhibitor 99.00% Phase 2
HY-P990752 Nezastomig / Phase 2

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05028 FOLH1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18175 Folh1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24649 Folh1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Bioactive MoleculesInhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991359 Anti-FOLH1/PSMA Antibody (J591) Inhibitor 95.05% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Folh1 NCBI NCBI:2346