SCIN - scinderin Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 85477

About SCIN

Cytogenetic location: 7p21.3 Genomic coordinates (GRCh38): 7:12,570,720-12,660,182 (from NCBI)

This gene has 10 transcripts (splice variants), 179 orthologues and 7 paralogues. Biased expression in small intestine (RPKM 29.7), kidney (RPKM 29.3) and 11 other tissues.

Summary

SCIN is a CA(2+)-dependent actin-severing and -capping protein (Zunino et al., 2001 [PubMed 11568009]).[supplied by OMIM, May 2010]

SCIN Products (2)

mRNA	Protein	Name
NM_001112706.3	NP_001106177.1	scinderin isoform 1
NM_033128.3	NP_149119.1	scinderin isoform 2

Gene Ontology

Biological Process

Biological Process GO Annotation	Evidence	References	Source
involved in actin filament capping	IMP IMP: Inferred from mutant phenotype	19666531	GOA
involved in actin filament severing	IMP IMP: Inferred from mutant phenotype	11568009	GOA
involved in negative regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	11568009	GOA
involved in positive regulation of actin nucleation	IMP IMP: Inferred from mutant phenotype	19666531	GOA
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	11568009	GOA
involved in positive regulation of megakaryocyte differentiation	IMP IMP: Inferred from mutant phenotype	11568009	GOA
involved in sequestering of actin monomers	IMP IMP: Inferred from mutant phenotype	19666531	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SCIN Protein Structure

Gelsolin

0
200
400
600
715 a.a.

Protein Preferred Names	Protein Names
scinderin	adseverin

SCIN Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82166	SCIN Antibody (YA1911)	WB, IHC-P	Human
HY-P82166A	SCIN Antibody (YA1911)(PBS only)	WB, IHC-P	Human

Related Diseases

Diseases	Alias
Ritter'S Disease	Staphylococcal Scalded Skin Syndrome Pemphigus Neonatorum Ritter Disease Dermatitis Exfoliativa Neonatorum Scalded Skin Syndrome Toxic Epidermal Necrolysis, Subcorneal Type Generalized Exfoliative Disease Ssss Ssss - [Staphylococcal Scalded Skin Syndrome]
Carbuncle	Carbuncle And Furuncle Of Any Part Of Face Except Eye Carbuncle And Furuncle Of Buttock Carbuncle And Furuncle Of Face Carbuncle And Furuncle Of Foot Carbuncle And Furuncle Of Gluteal Region Carbuncle And Furuncle Of Hand Carbuncle And Furuncle Of Leg Except Foot Carbuncle And Furuncle Of Neck Carbuncle And Furuncle Of Trunk Carbuncle And Furuncle Of Upper Arm And Forearm
Endocardium Disease
Septic Arthritis	Infectious Arthritis Arthritis, Infectious Arthritis Septic Arthritis, Bacterial
Waterhouse-Friderichsen Syndrome	Fatal Pneumococcal Waterhouse-Friderichsen Syndrome Meningococcal Hemorrhagic Adrenalitis Waterhouse-Friderichsen Syndrome, Meningococcal Meningococcal Haemorrhagic Adrenalitis Meningococcal Adrenal Syndrome Acute Adrenal Insufficiency With Meningococcal Septicaemia Adrenal Haemorrhage Syndrome Waterhouse-Friderichsen Disease Meningococcal Waterhouse-Friderichsen Syndrome Haemorrhagic Meningococcal Adrenitis
Commensal Bacterial Infectious Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12512	SCIN Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17695	Scin Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24157	Scin Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	SCIN	VGNC	VGNC:34339
Felis catus	SCIN	VGNC	VGNC:64914
Mus musculus	SCIN	MGD	MGI:1306794
Macaca mulatta	SCIN	VGNC	VGNC:81562
Rattus norvegicus	SCIN	RGD	RGD:735034
Others	SCIN	NCBI