SCIN Antibody (YA1911)(PBS only)
(Synonyms: Scinderin)SCIN Antibody (YA1911) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SCIN.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P
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Reactivity :
Human
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Formulation:
Supplied in PBS, pH 7.4.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|---|
| Dilution Ratio | 1:500-1:1000 | 1:50-1:100 |
Product Details
SCIN Antibody (YA1911) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SCIN.
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Host Rabbit
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 80 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 80 kDa
A synthetic peptide of human SCIN aa 669-682.
Affinity Purified
Non-conjugated
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS, pH 7.4.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
SCIN is a Ca(2+)-dependent actin filament-severing protein that has a regulatory function in exocytosis by affecting the organization of the microfilament network underneath the plasma membrane. Severing activity is inhibited by phosphatidylinositol 4,5-bis-phosphate (PIP2). In vitro, also has barbed end capping and nucleating activities in the presence of Ca(2+). Required for megakaryocyte differentiation, maturation, polyploidization and apoptosis with the release of platelet-like particles. Plays a role in osteoclastogenesis (OCG) and actin cytoskeletal organization in osteoclasts. Regulates chondrocyte proliferation and differentiation. Inhibits cell proliferation and tumorigenesis. Signaling is mediated by MAPK, p38 and JNK pathways[1][2][3].
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Subcellular Localization
Cytoplasm, cytoskeleton; Cell projection, podosome
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Expression
Tissue_specificity:Expressed in megakaryocytes -
Isoforms & Post-Translational Modification
Q9Y6U3 has 3 isomers: Q9Y6U3-1: 80489 Da (predicted); Q9Y6U3-2: 65357 Da (predicted); Q9Y6U3-3: 52814 Da (predicted).
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SwissProt ID
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Synonyms
Scinderin
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Research Field
Signal Transduction
Documentation
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