SCIN Antibody (YA1911)(PBS only)

Cat. No.: HY-P82166A: Fiche technique User Guide for Antibodies
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SCIN Antibody (YA1911) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SCIN.

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Size		Stock
50 μL		Obtenir un devis
100 μL		Obtenir un devis

* Veuillez sélectionner la quantité avant d'ajouter des articles.

WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Description

Description

SCIN Antibody (YA1911) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SCIN.

Host

Rabbit

Masse moléculaire

Predicted band size: 80 kDa;

Observed band size: 80 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human

SwissProt ID

Q9Y6U3

Gene ID

85477 [NCBI]

Immunogen

A synthetic peptide of human SCIN aa 669-682.

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:500-1:1000
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:50-1:100

Pureté	Affinity Purified	Conjugation	Non-conjugated
Isotype	IgG

Appearance

Liquid

Formulation

Supplied in PBS, pH 7.4.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Livraison

Shipping with blue ice.

Background

Function：Ca(2+)-dependent actin filament-severing protein that has a regulatory function in exocytosis by affecting the organization of the microfilament network underneath the plasma membrane (PubMed:26365202, PubMed:8547642). Severing activity is inhibited by phosphatidylinositol 4,5-bis-phosphate (PIP2) (By similarity). In vitro, also has barbed end capping and nucleating activities in the presence of Ca(2+). Required for megakaryocyte differentiation, maturation, polyploidization and apoptosis with the release of platelet-like particles (PubMed:11568009). Plays a role in osteoclastogenesis (OCG) and actin cytoskeletal organization in osteoclasts (By similarity). Regulates chondrocyte proliferation and differentiation (By similarity). Inhibits cell proliferation and tumorigenesis. Signaling is mediated by MAPK, p38 and JNK pathways (PubMed:11568009)

Subcellular Localization：Cytoplasm, cytoskeleton; Cell projection, podosome

Expression：
Tissue_specificity:Expressed in megakaryocytes

Isoforms & Post-Translational Modification：Q9Y6U3 has 3 isomers: Q9Y6U3-1: 80489 Da (predicted); Q9Y6U3-2: 65357 Da (predicted); Q9Y6U3-3: 52814 Da (predicted).

Research Field

Signal Transduction

Synonyms

Scinderin

Documentation

User Guide for Antibodies (1077 KB)