STK19 - serine/threonine kinase 19 Gene

Also Known as G11; RP1; D6S60; D6S60E; HLA-RP1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8859

About STK19

Cytogenetic location: 6p21.33 Genomic coordinates (GRCh38): 6:31,971,175-31,981,446 (from NCBI)

This gene has 18 transcripts (splice variants), 1 gene allele and 183 orthologues. Ubiquitous expression in adrenal (RPKM 19.3), testis (RPKM 9.7) and 25 other tissues.

Summary

This gene encodes a serine/threonine kinase which localizes predominantly to the nucleus. Its specific function is unknown; it is possible that phosphorylation of this protein is involved in transcriptional regulation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6 and expresses two transcript variants. [provided by RefSeq, Jul 2008]

STK19 Products (2)

mRNA Protein Name
NM_004197.2 NP_004188.2 serine/threonine-protein kinase 19 isoform 1
NM_032454.1 NP_115830.1 serine/threonine-protein kinase 19 isoform 2

STK19 Protein Structure

Stk19

Stk19: Serine-threonine protein kinase 19 (148 - 361)

  • 0
  • 100
  • 200
  • 300
  • 364 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase 19

  • MHC class III HLA-RP1

STK19 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
STK19 P49842 ASB3 Homo sapiens Q9Y575
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Skin Squamous Cell Carcinoma

  • Squamous Cell Carcinoma Of Skin

  • Epidermoid Skin Carcinoma

  • Squamous Cell Carcinoma Of The Skin

  • Squamous Cell Epithelioma Of Skin

  • Cutaneous Squamous Cell Carcinoma

  • Scc - [Squamous Cell Carcinoma] Of Skin
Skin Melanoma

  • Cutaneous Melanoma

  • Malignant Ear Melanoma

  • Malignant Lip Melanoma

  • Malignant Lower Limb Melanoma

  • Malignant Melanoma Of Ear And/Or External Auricular Canal

  • Malignant Melanoma Of Skin Of Lower Limb

  • Malignant Melanoma Of Skin Of Trunk Except Scrotum

  • Malignant Melanoma Of Skin Of Upper Limb

  • Malignant Neck Melanoma

  • Malignant Scalp Melanoma

  • Malignant Trunk Melanoma

  • Malignant Upper Limb Melanoma

  • Melanoma, Cutaneous Malignant

  • Melanoma

  • Malignant Melanoma Of Skin

  • Melanoma Nos

  • Malignant Mole, Meaning Melanoma Of Unspecified Site

  • Melanoma Of Unspecified Site

  • Cutaneous Malignant Melanoma

  • Mm - [Malignant Melanoma]
Hyperpigmentation Of The Skin
Retinitis Pigmentosa 4

  • RP4

  • Retinitis Pigmentosa 4, Autosomal Dominant Or Recessive

  • Retinitis Pigmentosa, Rhodopsin-Related

  • Retinitis Pigmentosa, Type 4
Melanoma

  • Malignant Melanoma

  • Cutaneous Melanoma

  • Naevocarcinoma

  • Malignant Melanomas
Retinitis Pigmentosa 3

  • RP3

  • Retinitis Pigmentosa 15

  • Rp15

  • Choroidoretinal Degeneration With Retinal Reflex In Heterozygous Women

  • Cone-Rod Degeneration, X-Linked

  • Retinitis Pigmentosa Type 15

  • X-Linked Cone-Rod Degeneration

  • X-Linked Retinitis Pigmentosa 3

  • Xlrp3

  • Xlrp-3

  • Retinitis Pigmentosa-3

  • Retinitis Pigmentosa, Type 3
Melanoma, Cutaneous Malignant 1

  • Familial Melanoma

  • Melanoma, Cutaneous Malignant, Susceptibility To, 1

  • Melanoma, Malignant

  • CMM1

  • Melanoma, Cutaneous Malignant

  • Cmm

  • Familial Atypical Mole-Malignant Melanoma Syndrome

  • Fammm

  • Melanoma, Familial

  • Mlm

  • Dysplastic Nevus Syndrome, Hereditary

  • Dns

  • B-K Mole Syndrome

  • Melanoma, Cutaneous Malignant, 1

  • Malignant Melanoma, Cutaneous

  • Melanoma, Cutaneous, Malignant, Susceptibility To, Type 1

  • Dysplastic Nevus Syndrome

  • Cutaneous Melanoma

  • Familial Atypical Mole Melanoma Syndrome

  • Hereditary Melanoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-122866 ZT-12-037-01 Inhibitor 98.06% Unkown
HY-RS13926 STK19 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21056 Stk19 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus STK19 RGD RGD:1359601
Macaca mulatta STK19 VGNC VGNC:83471
Mus musculus STK19 MGD MGI:1860085
Bos taurus STK19 VGNC VGNC:35389
Others STK19 NCBI