NPEPPS - aminopeptidase puromycin sensitive Gene

Also Known as PSA; AAP-S; MP100

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9520

About NPEPPS

Cytogenetic location: 17q21.32 Genomic coordinates (GRCh38): 17:47,522,933-47,623,276 (from NCBI)

This gene has 41 transcripts (splice variants), 224 orthologues and 11 paralogues. Ubiquitous expression in esophagus (RPKM 43.2), brain (RPKM 28.6) and 25 other tissues.

Summary

This gene encodes the puromycin-sensitive Aminopeptidase, a zinc metallopeptidase which hydrolyzes Amino acids from the N-terminus of its substrate. The protein has been localized to both the cytoplasm and to cellular membranes. This enzyme degrades enkaphalins in the brain, and studies in mouse suggest that it is involved in proteolytic events regulating the cell cycle. [provided by RefSeq, Jul 2008]

NPEPPS Products (3)

mRNA Protein Name
NM_001330257.2 NP_001317186.1 puromycin-sensitive aminopeptidase isoform 2
NM_001411130.1 NP_001398059.1 puromycin-sensitive aminopeptidase isoform 3
NM_006310.4 NP_006301.3 puromycin-sensitive aminopeptidase isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables aminopeptidase activity EXP
EXP: Inferred from Experiment
9668046 GOA
Biological Process GO Annotation Evidence References Source
involved in cellular response to hypoxia IDA
IDA: Inferred from direct assay
21056661 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NPEPPS Protein Structure

Peptidase_M1

Peptidase_M1: Peptidase family M1 domain (53 - 441)

ERAP1_C

ERAP1_C: ERAP1-like C-terminal domain (578 - 891)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 919 a.a.
Protein Preferred Names Protein Names

puromycin-sensitive aminopeptidase

  • cytosol alanyl aminopeptidase

NPEPPS Antibodies

Cat. No. Product Name Application Reactivity
HY-P811352 NPEPPS/PSA Antibody WB Human
HY-P89166 NPEPPS Antibody IHC-P Mouse

Related Diseases

Diseases Alias
Frontotemporal Dementia

  • Pallidopontonigral Degeneration

  • Frontotemporal Lobar Degeneration

  • Semantic Dementia

  • FTD

  • Frontotemporal Lobe Dementia

  • Multiple System Tauopathy With Presenile Dementia

  • Dementia, Frontotemporal

  • Frontotemporal Dementia With Parkinsonism

  • Mstd

  • Frontotemporal Lobar Degeneration With Tau Inclusions

  • Ftld With Tau Inclusions

  • Dementia, Frontotemporal, With Parkinsonism

  • Fldem

  • Ftdp17

  • Disinhibition-Dementia-Parkinsonism-Amyotrophy Complex

  • Ddpac

  • Wilhelmsen-Lynch Disease

  • Wld

  • Ppnd

  • Dementia, Frontotemporal, With Or Without Parkinsonism

  • Semantic Primary Progressive Aphasia

  • Semantic Variant Ppa

  • Wilhemsen-Lynch Disease

  • Frontotemporal Dementia-Amyotrophic Lateral Sclerosis

  • Frontotemporal Dementia And Parkinsonism Linked To Chromosome 17

  • Ftd-Als

  • Ftld

  • Pick Complex

  • Pick Disease Of The Brain

  • Frontotemporal Dementia With Parkinsonism-17

  • Grn-Related Frontotemporal Dementia

  • Frontotemporal Dementia With Motor Neuron Disease

  • Dementia In Fronto-Temporal Lobar Degeneration

  • Ftd - [Frontotemporal Dementia]

  • Temple Dementia

  • Frontal Lobe Dementia
Alzheimer Disease, Familial, 1

  • Alzheimer Disease

  • Alzheimer'S Disease

  • Presenile And Senile Dementia

  • AD1

  • Alzheimer Disease, Susceptibility To

  • Alzheimer Disease, Late-Onset, Susceptibility To

  • Alzheimer Disease 1, Familial

  • AD

  • Familial Alzheimer Disease

  • Alzheimer Disease, Late-Onset

  • Alzheimers Dementia

  • Alzheimer Dementia

  • Alzheimer Sclerosis

  • Alzheimer Syndrome

  • Alzheimer-Type Dementia

  • Dat

  • Primary Senile Degenerative Dementia

  • Sdat

  • Alzheimer Disease 1

  • Autosomal Dominant Alzheimer Disease

  • Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy

  • Late Onset Alzheimer Disease

  • Alzheimers Disease

  • Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy

  • Late-Onset Alzheimers Disease

  • Alzheimer'S Disease Pathway Kegg

  • Dementia Due To Alzheimer'S Disease

  • Alzheimer Disease Type 1

  • Alzheimers
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09479 NPEPPS Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus NPEPPS RGD RGD:619962
Mus musculus NPEPPS MGD MGI:1101358
Felis catus NPEPPS VGNC VGNC:97532
Bos taurus NPEPPS VGNC VGNC:57146
Canis familiaris NPEPPS VGNC VGNC:97210
Macaca mulatta NPEPPS VGNC VGNC:97796
Others NPEPPS NCBI