NPEPPS - aminopeptidase puromycin sensitive Gene

Homo sapiens

Also known as PSA; AAP-S; MP100

Gene ID: 9520 | Gene type: protein coding

About NPEPPS

Cytogenetic location: 17q21.32 Genomic coordinates (GRCh38): 17:47,522,933-47,623,276 (from NCBI)

This gene has 41 transcripts (splice variants), 224 orthologues and 11 paralogues. Ubiquitous expression in esophagus (RPKM 43.2), brain (RPKM 28.6) and 25 other tissues.

Summary

This gene encodes the puromycin-sensitive Aminopeptidase, a zinc metallopeptidase which hydrolyzes Amino acids from the N-terminus of its substrate. The protein has been localized to both the cytoplasm and to cellular membranes. This Enzyme degrades enkaphalins in the brain, and studies in mouse suggest that it is involved in proteolytic events regulating the cell cycle. [provided by RefSeq, Jul 2008]

NPEPPS Products(3)

mRNA	Protein	Name
NM_001330257.2	NP_001317186.1	puromycin-sensitive aminopeptidase isoform 2
NM_001411130.1	NP_001398059.1	puromycin-sensitive aminopeptidase isoform 3
NM_006310.4	NP_006301.3	puromycin-sensitive aminopeptidase isoform 1

NPEPPS Protein Structure

Peptidase_M1

ERAP1_C

0
200
400
600
800
919 a.a.

Protein Preferred Names

Protein Names

puromycin-sensitive aminopeptidase

cytosol alanyl aminopeptidase

Related Diseases

Diseases

Alias

Frontotemporal Dementia

Pallidopontonigral Degeneration	Frontotemporal Lobar Degeneration
Semantic Dementia	FTD
Frontotemporal Lobe Dementia	Multiple System Tauopathy With Presenile Dementia
Dementia, Frontotemporal	Frontotemporal Dementia With Parkinsonism
Mstd	Frontotemporal Lobar Degeneration With Tau Inclusions
Ftld With Tau Inclusions	Dementia, Frontotemporal, With Parkinsonism
Fldem	Ftdp17
Disinhibition-Dementia-Parkinsonism-Amyotrophy Complex	Ddpac
Wilhelmsen-Lynch Disease	Wld
Ppnd	Dementia, Frontotemporal, With Or Without Parkinsonism
Semantic Primary Progressive Aphasia	Semantic Variant Ppa
Wilhemsen-Lynch Disease	Frontotemporal Dementia-Amyotrophic Lateral Sclerosis
Frontotemporal Dementia And Parkinsonism Linked To Chromosome 17	Ftd-Als
Ftld	Pick Complex
Pick Disease Of The Brain	Frontotemporal Dementia With Parkinsonism-17
Grn-Related Frontotemporal Dementia	Frontotemporal Dementia With Motor Neuron Disease
Dementia In Fronto-Temporal Lobar Degeneration	Ftd - [Frontotemporal Dementia]
Temple Dementia	Frontal Lobe Dementia

Alzheimer Disease, Familial, 1

Alzheimer Disease	Alzheimer'S Disease
Presenile And Senile Dementia	AD1
Alzheimer Disease, Susceptibility To	Alzheimer Disease, Late-Onset, Susceptibility To
Alzheimer Disease 1, Familial	AD
Familial Alzheimer Disease	Alzheimer Disease, Late-Onset
Alzheimers Dementia	Alzheimer Dementia
Alzheimer Sclerosis	Alzheimer Syndrome
Alzheimer-Type Dementia	Dat
Primary Senile Degenerative Dementia	Sdat
Alzheimer Disease 1	Autosomal Dominant Alzheimer Disease
Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy	Late Onset Alzheimer Disease
Alzheimers Disease	Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy
Late-Onset Alzheimers Disease	Alzheimer'S Disease Pathway Kegg
Dementia Due To Alzheimer'S Disease	Alzheimer Disease Type 1
Alzheimers

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09479	NPEPPS Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	NPEPPS	RGD	RGD:619962
Mus musculus	NPEPPS	MGD	MGI:1101358
Felis catus	NPEPPS	VGNC	VGNC:97532
Bos taurus	NPEPPS	VGNC	VGNC:57146
Canis familiaris	NPEPPS	VGNC	VGNC:97210
Macaca mulatta	NPEPPS	VGNC	VGNC:97796

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