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Mael - maelstrom spermatogenic transposon silencer Gene

Also Known as 4933405K18Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 98558

Summary

Predicted to enable sequence-specific DNA binding activity. Involved in DNA methylation involved in gamete generation; gene silencing by RNA; and piRNA metabolic process. Acts upstream of or within several processes, including intrinsic apoptotic signaling pathway in response to DNA damage; male gamete generation; and negative regulation of macromolecule metabolic process. Located in several cellular components, including chromosome; cytoplasmic ribonucleoprotein granule; and perinuclear region of cytoplasm. Is expressed in brain; early conceptus; and genitourinary system. Orthologous to human MAEL (maelstrom spermatogenic transposon silencer). [provided by Alliance of Genome Resources, Apr 2022]

Mael Products (1)

mRNA	Protein	Name
NM_175296.4	NP_780505.1	protein maelstrom homolog

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16787967	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within DNA damage response	IMP IMP: Inferred from mutant phenotype	18694567	MGI
acts upstream of apoptotic process	IMP IMP: Inferred from mutant phenotype	18694567	MGI
acts upstream of or within cell morphogenesis	IMP IMP: Inferred from mutant phenotype	18694567	MGI
acts upstream of ectopic germ cell programmed cell death	IMP IMP: Inferred from mutant phenotype	18694567	MGI
acts upstream of or within fertilization	IMP IMP: Inferred from mutant phenotype	18694567	MGI
acts upstream of gene expression	IMP IMP: Inferred from mutant phenotype	18694567	MGI
acts upstream of or within homologous chromosome pairing at meiosis	IMP IMP: Inferred from mutant phenotype	18694567	MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage	IMP IMP: Inferred from mutant phenotype	18694567	MGI
acts upstream of or within male meiotic nuclear division	IMP IMP: Inferred from mutant phenotype	18694567	MGI
acts upstream of or within negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	18694567	MGI
acts upstream of or within negative regulation of developmental process	IMP IMP: Inferred from mutant phenotype	18694567	MGI
acts upstream of or within negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	18694567	MGI
acts upstream of or within negative regulation of reproductive process	IMP IMP: Inferred from mutant phenotype	18694567	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	18694567	MGI
involved in piRNA processing	IMP IMP: Inferred from mutant phenotype	18694567	MGI
acts upstream of or within regulation of organ growth	IMP IMP: Inferred from mutant phenotype	18694567	MGI
involved in regulatory ncRNA-mediated gene silencing	IMP IMP: Inferred from mutant phenotype	18694567	MGI
involved in retrotransposon silencing by piRNA-directed DNA methylation	IMP IMP: Inferred from mutant phenotype	20011505	MGI
acts upstream of or within spermatogenesis	IMP IMP: Inferred from mutant phenotype	18694567	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in P granule	IDA IDA: Inferred from direct assay	16787967	MGI
NOT located in XY body	IDA IDA: Inferred from direct assay	18694567	MGI
located in XY body	IDA IDA: Inferred from direct assay	16787967	MGI
located in autosome	IDA IDA: Inferred from direct assay	16787967	MGI
located in chromatin	IDA IDA: Inferred from direct assay	16787967	MGI
located in chromatoid body	IDA IDA: Inferred from direct assay	16787967	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	16787967	MGI
located in male germ cell nucleus	IDA IDA: Inferred from direct assay	16787967	MGI
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	18694567	MGI
located in piP-body	IDA IDA: Inferred from direct assay	20011505	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
protein maelstrom homolog	maelstrom homolog

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07955	MAEL Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21370	Mael Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27889	Mael Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Mael	NCBI	NCBI:84944