SV2B - synaptic vesicle glycoprotein 2B Gene

Also Known as SLC22B2; HsT19680

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9899

About SV2B

Cytogenetic location: 15q26.1 Genomic coordinates (GRCh38): 15:91,099,588-91,302,565 (from NCBI)

This gene has 6 transcripts (splice variants), 268 orthologues and 2 paralogues. Biased expression in brain (RPKM 7.7) and fat (RPKM 1.1).

Summary

This gene encodes a member of the Synaptic Vesicle Proteins 2 (SV2) family and major facilitator superfamily of proteins. This protein and Other members of the family are localized to synaptic vesicles and may function in the regulation of vesicle trafficking and exocytosis. Studies in mice suggest that the encoded protein may act as a protein receptor for botulinum neurotoxin E in neurons, and that this protein may be important for the integrity of the glomerular filtration barrier. This gene shows reduced expression in areas of synaptic loss in the hippocampus of human temporal lobe epilepsy patients. [provided by RefSeq, Sep 2016]

SV2B Products (11)

mRNA Protein Name
NM_001167580.3 NP_001161052.1 synaptic vesicle glycoprotein 2B isoform 2
NM_001323031.2 NP_001309960.1 synaptic vesicle glycoprotein 2B isoform 1
NM_001323032.3 NP_001309961.1 synaptic vesicle glycoprotein 2B isoform 1
NM_001323033.3 NP_001309962.1 synaptic vesicle glycoprotein 2B isoform 3
NM_001323034.3 NP_001309963.1 synaptic vesicle glycoprotein 2B isoform 4
NM_001323036.3 NP_001309965.1 synaptic vesicle glycoprotein 2B isoform 5
NM_001323037.3 NP_001309966.1 synaptic vesicle glycoprotein 2B isoform 1
NM_001323038.3 NP_001309967.1 synaptic vesicle glycoprotein 2B isoform 1
NM_001323039.3 NP_001309968.1 synaptic vesicle glycoprotein 2B isoform 1
NM_001323040.3 NP_001309969.1 synaptic vesicle glycoprotein 2B isoform 2
NM_014848.7 NP_055663.1 synaptic vesicle glycoprotein 2B isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SV2B Protein Structure

Sugar_tr

Sugar_tr: Sugar (and other) transporter (131 - 327)

Pentapeptide_4

Pentapeptide_4: Pentapeptide repeats (9 copies) (456 - 527)

MFS_1

MFS_1: Major Facilitator Superfamily (539 - 677)

  • 0
  • 200
  • 400
  • 600
  • 683 a.a.
Protein Preferred Names Protein Names

synaptic vesicle glycoprotein 2B

  • solute carrier family 22 member B2

SV2B Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SV2B Q7L1I2 HSFY1 Homo sapiens Q96LI6
Validated Y2H
25416956
Intra
SV2B Q7L1I2 HSFY1 Homo sapiens Q96LI6
Y2H Array
25416956
Intra
SV2B Q7L1I2 HSFY1 Homo sapiens Q96LI6
Y2H Prey Pooling
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Temporal Lobe Epilepsy

  • Epilepsy, Temporal Lobe

  • Epilepsy Temporal Lobe
Prostate Small Cell Carcinoma

  • Small Cell Carcinoma Of Prostate

  • Prostate Oat Cell Carcinoma
Foodborne Botulism

  • Botulism

  • Botulism Poisoning

  • Intoxication With Clostridium Botulinum Toxin

  • Wound Botulism

  • Food Poisoning Due To Clostridium Botulinum

  • Infection Due To Clostridium Botulinum

  • Infant Botulism

  • Intoxication Botulism

  • Botulism, Infantile

  • Clostridium Botulinum Poisoning

  • Botulism Nos
Epilepsy

  • Epilepsy Syndrome

  • Epileptic Syndrome

  • Epilepsies

  • Symptomatic Epilepsies

  • Post Traumatic Epilepsy

  • Traumatic Epilepsy

  • Traumatic Epileptic

  • Epilepsy Due To Hippocampal Sclerosis

  • Epilepsy With Ammon'S Horn Sclerosis

  • Epilepsy Due To Cortical Dysplasia

  • Epilepsy Due To Neuronal Migration Disorders
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14055 SV2B Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus SV2B VGNC VGNC:35495
Rattus norvegicus SV2B RGD RGD:619716
Canis familiaris SV2B VGNC VGNC:47004
Macaca mulatta SV2B VGNC VGNC:78140
Felis catus SV2B VGNC VGNC:65861
Mus musculus SV2B MGD MGI:1927338
Others SV2B NCBI