I-XW-053 sodium
I-XW-053 sodium is a specific anti-HIV-1 capsid inhibitor (IC50=164.2 μM). By binding to the CA NTD-NTD hexamerization interface and the R173 region of CTD (Kd=66.3 μM), I-XW-053 sodium disrupts capsid function and reduces polymerization levels. I-XW-053 sodium effectively blocks HIV-1 uncoating, inhibits reverse transcription and early replication, and exhibits broad-spectrum activity against primary HIV-1 isolates in peripheral blood mononuclear cells. I-XW-053 sodium can be widely used in studies related to HIV-1 infection.
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- CAS No.: 1644644-89-2
- 화학식: C22H15N2NaO2
- 분자량:362.36
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
I-XW-053 sodium (0.86-110 μM; 30 min+48 h) inhibits single-round HIV-1 (YU-2 envelope) infection of Cf2Th/CD4-CCR5 cells, with an IC50 of 22.5 μM[1].
I-XW-053 sodium potently inhibits the replication of multiple primary HIV-1 isolates in human primary PBMC, with no cytotoxicity detected[1].
I-XW-053 sodium (100 μM; 24 h) significantly reduces the levels of HIV-1 late reverse transcription products in P4-R5 MAGI cells, U87.CD4.CXCR4 cells, and MDM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1644644-89-2
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분자량 362.36
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화학식 C22H15N2NaO2
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SMILES
O=C(O[Na])C1=CC=C(C2=NC(C3=CC=CC=C3)=C(C4=CC=CC=C4)N2)C=C1
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
[1]. Kortagere S, et al. Inhibiting early-stage events in HIV-1 replication by small-molecule targeting of the HIV-1 capsid. J Virol. 2012;86(16):8472-8481. [Content Brief]
[2]. Chia T, et al. A Small Molecule, ACAi-028, with Anti-HIV-1 Activity Targets a Novel Hydrophobic Pocket on HIV-1 Capsid. Antimicrob Agents Chemother. 2021;65(10):e0103921. [Content Brief]
[3]. Fricke T, et al. Human cytosolic extracts stabilize the HIV-1 core. J Virol. 2013;87(19):10587-10597. [Content Brief]
[4]. Kortagere S, et al. Structure-activity relationships of a novel capsid targeted inhibitor of HIV-1 replication. J Chem Inf Model. 2014;54(11):3080-3090. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
I-XW-053 sodium Related Classifications
HY-103078A Related Classifications
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