2. Anti-infection
  3. HIV Reverse Transcriptase
  4. I-XW-053 sodium

I-XW-053 sodium is a specific anti-HIV-1 capsid inhibitor (IC50=164.2 μM). By binding to the CA NTD-NTD hexamerization interface and the R173 region of CTD (Kd=66.3 μM), I-XW-053 sodium disrupts capsid function and reduces polymerization levels. I-XW-053 sodium effectively blocks HIV-1 uncoating, inhibits reverse transcription and early replication, and exhibits broad-spectrum activity against primary HIV-1 isolates in peripheral blood mononuclear cells. I-XW-053 sodium can be widely used in studies related to HIV-1 infection.

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I-XW-053 sodium

I-XW-053 sodium Chemical Structure

CAS No. : 1644644-89-2

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I-XW-053 sodium Related Antibodies

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Description

I-XW-053 sodium is a specific anti-HIV-1 capsid inhibitor (IC50=164.2 μM). By binding to the CA NTD-NTD hexamerization interface and the R173 region of CTD (Kd=66.3 μM), I-XW-053 sodium disrupts capsid function and reduces polymerization levels. I-XW-053 sodium effectively blocks HIV-1 uncoating, inhibits reverse transcription and early replication, and exhibits broad-spectrum activity against primary HIV-1 isolates in peripheral blood mononuclear cells. I-XW-053 sodium can be widely used in studies related to HIV-1 infection[1][2][3][4].

In Vitro

I-XW-053 sodium (0.86-110 μM; 30 min+48 h) inhibits single-round HIV-1 (YU-2 envelope) infection of Cf2Th/CD4-CCR5 cells, with an IC50 of 22.5 μM[1].
I-XW-053 sodium potently inhibits the replication of multiple primary HIV-1 isolates in human primary PBMC, with no cytotoxicity detected[1].
I-XW-053 sodium (100 μM; 24 h) significantly reduces the levels of HIV-1 late reverse transcription products in P4-R5 MAGI cells, U87.CD4.CXCR4 cells, and MDM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

I-XW-053 sodium Related Antibodies
Molecular Weight

362.36

Formula

C22H15N2NaO2
CAS No.
SMILES

O=C(O[Na])C1=CC=C(C2=NC(C3=CC=CC=C3)=C(C4=CC=CC=C4)N2)C=C1
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
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I-XW-053 sodium Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

I-XW-0531644644-89-2HIVReverse TranscriptaseHuman immunodeficiency virusantiviral activityInhibitorinhibitorinhibit

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