3083249-46-8
3083249-46-8
Chemical Structure
AH-26
- CAS No.: 3083249-46-8
- Formula:C21H23NO4
- Molecular Weight:353.41
InChIKey: WJSLFRUIHYVANY-ZJOUEHCJSA-N
SMILES: O=C(O1)C=C2[C@@]13[C@@](CCCC4)([H])N4[C@](C3)([H])C(C5=CC(OC)=CC(OC)=C5)=C2
Biological Activity: AH-26 is a STAT3 inhibitor. AH-26 stabilizes the STAT3 protein, inhibits STAT3 phosphorylation, induces mitochondria-mediated apoptosis, triggers differentiation of leukemia cells, suppresses cancer cell migration, and arrests the cell cycle at the G1 phase. AH-26 exhibits antitumor activity without toxicity in nude mice. AH-26 can be used in the research of leukemia, ovarian cancer, gastric cancer, and pancreatic cancer[1].
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AH-26 | AH-26 is a STAT3 inhibitor. AH-26 stabilizes the STAT3 protein, inhibits STAT3 phosphorylation, induces mitochondria-mediated apoptosis, triggers differentiation of leukemia cells, suppresses cancer cell migration, and arrests the cell cycle at the G1 phase. AH-26 exhibits antitumor activity without toxicity in nude mice. AH-26 can be used in the research of leukemia, ovarian cancer, gastric cancer, and pancreatic cancer. | |||||||||||||||||||||
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