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POLDIP3 - DNA polymerase delta interacting protein 3 Gene

Also Known as SKAR; PDIP3; PDIP46

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 84271

About POLDIP3

Cytogenetic location: 22q13.2 Genomic coordinates (GRCh38): 22:42,583,721-42,614,883 (from NCBI)

This gene has 8 transcripts (splice variants), 213 orthologues and 2 paralogues. Ubiquitous expression in ovary (RPKM 49.2), bone marrow (RPKM 26.9) and 25 other tissues.

Summary

This gene encodes an RRM (RNA recognition motif)-containing protein that participates in the regulation of translation by recruiting ribosomal protein S6 kinase beta-1 to mRNAs. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

POLDIP3 Products (4)

mRNA	Protein	Name
NM_001278657.2	NP_001265586.1	polymerase delta-interacting protein 3 isoform 3
NM_001363052.2	NP_001349981.1	polymerase delta-interacting protein 3 isoform 4
NM_032311.5	NP_115687.2	polymerase delta-interacting protein 3 isoform 1
NM_178136.3	NP_835237.1	polymerase delta-interacting protein 3 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	18423201	GOA
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	18423201	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in poly(A)+ mRNA export from nucleus	IDA IDA: Inferred from direct assay	22928037	GOA
involved in positive regulation of translation	IMP IMP: Inferred from mutant phenotype	18423201	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in nuclear speck	IDA IDA: Inferred from direct assay	18423201	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

POLDIP3 Protein Structure

RRM_1

0
100
200
300
400
421 a.a.

Protein Preferred Names	Protein Names
polymerase delta-interacting protein 3	46 kDa DNA polymerase delta interaction protein

POLDIP3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	POLDIP3	Q9BY77	NCBP1	Homo sapiens	Q09161	Anti Bait CoIP	18423201
Intra	POLDIP3	Q9BY77	UBR1	Homo sapiens	Q8IWV7	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Methylmalonic Aciduria, Cblb Type	Methylmalonic Aciduria Cblb Type Methylmalonic Acidemia Cblb Type Methylmalonic Aciduria, Vitamin B12-Responsive, Due To Defect In Synthesis Of Adenosylcobalamin, Cblb Complementation Type Methylmalonic Acidemia, Cblb Type Methylmalonic Aciduria, Vitamin B12-Responsive, Due To Defect In Synthesis Of Adenosylcobalamin, Cblb Type Methylmalonic Aciduria, Vitamin B12-Responsive, Cblb Type Vitamin B12-Responsive Methylmalonic Acidemia Type Cblb Vitamin B12-Responsive Methylmalonic Aciduria, Type Cblb Methylmalonic Aciduria Type Cblb MMAB Methylmalonic Aciduria Type B Vitamin B12 Responsive Methylmalonic Acidemia Type Cbl B Vitamin B12 Responsive Methylmalonic Aciduria Type Cbl B Aciduria, Methylmalonic, Cblb Type Methylmalonic Acidemia Methylmalonic Aciduria

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10824	POLDIP3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	POLDIP3	MGD	MGI:1921076
Canis familiaris	POLDIP3	VGNC	VGNC:44778
Rattus norvegicus	POLDIP3	RGD	RGD:1311073
Macaca mulatta	POLDIP3	VGNC	VGNC:97119
Bos taurus	POLDIP3	VGNC	VGNC:33117
Felis catus	POLDIP3	VGNC	VGNC:64284
Others	POLDIP3	NCBI