2. Cell Cycle/DNA Damage Cytoskeleton Apoptosis
  3. Microtubule/Tubulin Apoptosis Bcl-2 Family Caspase
  4. iMPZ-8

iMPZ-8 is a β-tubulin polymerization inhibitor that inhibits β-tubulin protein expression, disrupts microtubule structure, impairs microtubule organization. iMPZ-8 inhibits proliferation and reduces cellular migration and colonization in cancer cells. iMPZ-8 induces G2/M phase arrestand induces apoptosis via the BAX-Caspase-3 intrinsic apoptotic signaling pathway. iMPZ-8 can be used for the research of cancer, suah as breast cancer, neuroblastoma and colon cancer.

For research use only. We do not sell to patients.

iMPZ-8

iMPZ-8 Chemical Structure

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iMPZ-8 Related Antibodies

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Description

iMPZ-8 is a β-tubulin polymerization inhibitor that inhibits β-tubulin protein expression, disrupts microtubule structure, impairs microtubule organization. iMPZ-8 inhibits proliferation and reduces cellular migration and colonization in cancer cells. iMPZ-8 induces G2/M phase arrestand induces apoptosis via the BAX-Caspase-3 intrinsic apoptotic signaling pathway. iMPZ-8 can be used for the research of cancer, suah as breast cancer, neuroblastoma and colon cancer[1].

IC50 & Target[1]

Bax

 

Bcl-2

 

Caspase 3

 

In Vitro

iMPZ-8 (1-80 μM; 72 h) potently inhibits proliferation in MDA-MB-231, SH-SY5Y, and DLD-1 cancer cells with IC50 values of 7.5 μM, 9.2 μM, and 19.7 μM, respectively[1].
iMPZ-8 (3 μM; 48 h) significantly inhibits β-tubulin expression and disrupts microtubule structure in MDA-MB-231 cells, with efficacy similar to nocodazole[1].
iMPZ-8 (3 μM; 48 h) inhibits migration in MDA-MB-231 cells by approximately 50%[1].
iMPZ-8 (3 μM; 7 to 10 days) reduces colony formation in MDA-MB-231 cells by approximately 30%[1].
iMPZ-8 (3 μM; 48 h) induces G2/M phase cell cycle arrest in MDA-MB-231 cells[1].
iMPZ-8 (3 μM; 48 h) induces intrinsic apoptosis via the BAX-Caspase-3 pathway in MDA-MB-231 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

iMPZ-8 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: MDA-MB-231, SH-SY5Y, DLD-1
Concentration: 1-80 μM
Incubation Time: 72 h
Result: Exhibited antiproliferative activity with IC50 values of 7.5 μM in MDA-MB-231 cells, 9.2 μM in SH-SY5Y cells, and 19.7 μM in DLD-1 cells.

ELISA Assay[1]

Cell Line: MDA-MB-231
Concentration: 3 μM
Incubation Time: 48 h
Result: Markedly inhibited β-tubulin protein expression, with effects comparable to Nocodazole (HY-13520) (a known β-tubulin antagonist).

Cell Cycle Analysis[1]

Cell Line: MDA-MB-231
Concentration: 3 μM
Incubation Time: 48 h
Result: Induced accumulation of cells in the G2/M phase of the cell cycle, similar to Nocodazole.

Apoptosis Analysis[1]

Cell Line: MDA-MB-231
Concentration: 3 μM
Incubation Time: 48 h
Result: Induced accumulation in early and late apoptosis.
Increased BAX and Caspase 3 levels and reduced Bcl-2 levels.
Molecular Weight

382.41

Formula

C23H18N4O2
SMILES

CC1=CC=C(C2=NN=C(C3=C(C4=CC=C(OC)C=C4)N=C5C=CC=CN53)O2)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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iMPZ-8 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

iMPZ-8iMPZ8iMPZ 8Microtubule/TubulinApoptosisBcl-2 FamilyCaspaseMDA-MB-231neuroblastomaβ-tubulinmicrotubule structureSH-SY5YG2/M phasebreast cancerBAX-Caspase-3microtubule organizationInhibitorinhibitorinhibit

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