CLTA - clathrin light chain A Gene

Also Known as LCA

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 1211

About CLTA

Cytogenetic location: 9p13.3 Genomic coordinates (GRCh38): 9:36,190,874-36,212,059 (from NCBI)

This gene has 8 transcripts (splice variants), 213 orthologues and 1 paralogue. Ubiquitous expression in colon (RPKM 66.3), kidney (RPKM 59.1) and 25 other tissues.

Summary

Clathrin is a large, soluble protein composed of heavy and light chains. It functions as the main structural component of the lattice-type cytoplasmic face of coated pits and vesicles which entrap specific macromolecules during receptor-mediated endocytosis. This gene encodes one of two clathrin light chain proteins which are believed to function as regulatory elements. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 8 and 12. [provided by RefSeq, May 2010]

CLTA Products (10)

mRNA Protein Name
NM_001076677.3 NP_001070145.1 clathrin light chain A isoform c
NM_001184760.2 NP_001171689.1 clathrin light chain A isoform d
NM_001184761.2 NP_001171690.1 clathrin light chain A isoform e
NM_001184762.2 NP_001171691.1 clathrin light chain A isoform f
NM_001311203.2 NP_001298132.1 clathrin light chain A isoform g
NM_001311204.2 NP_001298133.1 clathrin light chain A isoform h
NM_001311205.2 NP_001298134.1 clathrin light chain A isoform i
NM_001311206.2 NP_001298135.1 clathrin light chain A isoform j
NM_001833.4 NP_001824.1 clathrin light chain A isoform a
NM_007096.4 NP_009027.1 clathrin light chain A isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables clathrin heavy chain binding IPI
IPI: Inferred from physical interaction
4066749 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16595675 GOA
Biological Process GO Annotation Evidence References Source
involved in clathrin coat assembly IMP
IMP: Inferred from mutant phenotype
11756460 GOA
Cellular Component GO Annotation Evidence References Source
part of clathrin coat IMP
IMP: Inferred from mutant phenotype
11756460 GOA
part of clathrin complex IDA
IDA: Inferred from direct assay
4066749 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CLTA Protein Structure

Clathrin_lg_ch

Clathrin_lg_ch: Clathrin light chain (20 - 247)

  • 0
  • 100
  • 200
  • 248 a.a.
Protein Preferred Names Protein Names

clathrin light chain A

  • clathrin, light polypeptide (Lca)

CLTA Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CLTA P09496 CALY Homo sapiens Q9NYX4
Confocal
16595675
Intra
CLTA P09496 CALY Homo sapiens Q9NYX4
Y2H
16595675
Intra
CLTA P09496 CALY Homo sapiens Q9NYX4
Pull Down
16595675
Intra
CLTA P09496 TACC3 Homo sapiens Q9Y6A5
Anti Bait CoIP
21297582
Intra
CLTA P09496 CLTC Homo sapiens Q00610
Anti Tag CoIP
35271311
Intra
CLTA P09496 CLTC Homo sapiens Q00610
Anti Bait CoIP
21297582
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02843 CLTA Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus CLTA VGNC VGNC:27469
Rattus norvegicus CLTA RGD RGD:70919
Canis familiaris CLTA VGNC VGNC:39365
Mus musculus CLTA MGD MGI:894297
Felis catus CLTA VGNC VGNC:60982
Macaca mulatta CLTA VGNC VGNC:71266
Others CLTA NCBI