ATRAID - all-trans retinoic acid induced differentiation factor Gene

Also Known as p18; APR3; APR-3; APR--3; PRO240; C2orf28; HSPC013

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 51374

About ATRAID

Cytogenetic location: 2p23.3 Genomic coordinates (GRCh38): 2:27,212,041-27,217,183 (from NCBI)

This gene has 6 transcripts (splice variants) and 188 orthologues. Ubiquitous expression in thyroid (RPKM 48.2), testis (RPKM 45.1) and 25 other tissues.

Summary

This gene is thought to be involved in Apoptosis, and may also be involved in hematopoietic development and differentiation. The use of alternative splice sites and promotors result in multiple transcript variants encoding different isoforms.[provided by RefSeq, Dec 2009]

ATRAID Products (2)

mRNA	Protein	Name
NM_001170795.4	NP_001164266.1	all-trans retinoic acid-induced differentiation factor isoform c precursor
NM_016085.5	NP_057169.2	all-trans retinoic acid-induced differentiation factor isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	18388313	GOA
enables xenobiotic transmembrane transporter activity	IDA IDA: Inferred from direct assay	29745899	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of osteoblast proliferation	IDA IDA: Inferred from direct assay	21723284	GOA
involved in negative regulation of protein catabolic process	IDA IDA: Inferred from direct assay	21723284	GOA
involved in positive regulation of bone mineralization	IDA IDA: Inferred from direct assay	21723284	GOA
involved in positive regulation of osteoblast differentiation	IDA IDA: Inferred from direct assay	21723284	GOA
involved in regulation of gene expression	IDA IDA: Inferred from direct assay	21723284	GOA
involved in xenobiotic transmembrane transport	IDA IDA: Inferred from direct assay	29745899	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in lysosomal membrane	IDA IDA: Inferred from direct assay	29745899	GOA
located in nuclear envelope	IDA IDA: Inferred from direct assay	21723284	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	21723284	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
all-trans retinoic acid-induced differentiation factor	apoptosis related protein APR-3

ATRAID Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ATRAID	Q6UW56	SNX9	Homo sapiens	Q9Y5X1	Anti Bait CoIP	18388313

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Cloacal Exstrophy	Oeis Complex Omphalocele-Cloacal Exstrophy-Imperforate Anus-Spinal Defect Syndrome Omphalocele, Exstrophy Of The Cloaca, Imperforate Anus, And Spinal Defects Compl Omphalocele, Exstrophy Of The Cloaca, Imperforate Anus, And Spinal Defects Complex Cloacal Exstrophy Sequence Omphalocele - Cloacal Exstrophy - Imperforate Anus - Spinal Defect Omphalocele, Exstrophy Of The Cloaca, Imperforate Anus, And Spinal Defects Omphalocele Exstrophy Imperforate Anus
Congenital Syphilis	Syphilis, Congenital Congenital Syphilis, Unspecified Mtct Of Syphilis Mother-To-Child Transmission Of Syphilis Syphilis Congenital Hereditary Syphilis Heredosyphilis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01248	ATRAID Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	ATRAID	VGNC	VGNC:38294
Bos taurus	ATRAID	VGNC	VGNC:54408
Felis catus	ATRAID	VGNC	VGNC:60033
Macaca mulatta	ATRAID	VGNC	VGNC:106132
Rattus norvegicus	ATRAID	RGD	RGD:1311605
Mus musculus	ATRAID	MGD	MGI:1918918
Others	ATRAID	NCBI