CD151 - CD151 molecule (Raph blood group) Gene

Also Known as EBS7; GP27; MER2; RAPH; SFA1; PETA-3; TSPAN24

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 977

About CD151

Cytogenetic location: 11p15.5 Genomic coordinates (GRCh38): 11:832,952-838,831 (from NCBI)

This gene has 23 transcripts (splice variants), 262 orthologues, 32 paralogues and is associated with 4 phenotypes. Ubiquitous expression in fat (RPKM 188.8), lung (RPKM 142.9) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and Other transmembrane 4 superfamily proteins. It is involved in cellular processes including cell adhesion and may regulate Integrin trafficking and/or function. This protein enhances cell motility, invasion and metastasis of Cancer cells. Multiple alternatively spliced transcript variants that encode the same protein have been described for this gene. [provided by RefSeq, Jul 2008]

CD151 Products (4)

mRNA	Protein	Name
NM_001039490.2	NP_001034579.1	CD151 antigen
NM_004357.5	NP_004348.2	CD151 antigen
NM_139029.2	NP_620598.1	CD151 antigen
NM_139030.4	NP_620599.1	CD151 antigen

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables integrin binding	IDA IDA: Inferred from direct assay	17716972	GOA
enables integrin binding	IPI IPI: Inferred from physical interaction	24220332	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10811835	GOA

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within positive regulation of cell migration	IDA IDA: Inferred from direct assay	17716972	GOA
acts upstream of or within positive regulation of cell migration	IMP IMP: Inferred from mutant phenotype	17716972	GOA
acts upstream of or within positive regulation of endocytosis	IDA IDA: Inferred from direct assay	17716972	GOA
acts upstream of or within positive regulation of endocytosis	IMP IMP: Inferred from mutant phenotype	17716972	GOA
acts upstream of or within wound healing, spreading of cells	IDA IDA: Inferred from direct assay	17716972	GOA
acts upstream of or within wound healing, spreading of cells	IMP IMP: Inferred from mutant phenotype	17716972	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in basement membrane	IDA IDA: Inferred from direct assay	23302890	GOA
located in cell surface	IDA IDA: Inferred from direct assay	17716972	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CD151 Protein Structure

Tetraspannin

0
100
200
253 a.a.

Protein Preferred Names	Protein Names
CD151 antigen	CD151 antigen (Raph blood group)

CD151 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CD151	P48509	ARL13B	Homo sapiens	Q3SXY8	Validated Y2H	32296183
Intra	CD151	P48509	ARL13B	Homo sapiens	Q3SXY8	Y2H Prey Pooling	32296183
Intra	CD151	P48509	ARL13B	Homo sapiens	Q3SXY8	Y2H Array	32296183
Intra	CD151	P48509	TSPAN18	Homo sapiens	Q8WUV1	Y2H Prey Pooling	32296183
Intra	CD151	P48509	TSPAN18	Homo sapiens	Q8WUV1	Validated Y2H	32296183
Intra	CD151	P48509	TSPAN18	Homo sapiens	Q8WUV1	Y2H Array	32296183
Intra	CD151	P48509	ITGA6	Homo sapiens	P23229	Confocal	10811835
Intra	CD151	P48509	ITGA6	Homo sapiens	P23229	Anti Bait CoIP	10811835
Intra	CD151	P48509	ITGA6	Homo sapiens	P23229	Anti Tag CoIP	33961781
Intra	CD151	P48509	ITGA6	Homo sapiens	P23229	Anti Tag CoIP	35271311
Intra	CD151	P48509	ITGA3	Homo sapiens	P26006	Anti Bait CoIP	10811835
Intra	CD151	P48509	ITGA3	Homo sapiens	P26006	Anti Tag CoIP	33961781
Intra	CD151	P48509	ITGA3	Homo sapiens	P26006	Confocal	10811835
Intra	CD151	P48509	ITGA3	Homo sapiens	P26006	Anti Bait CoIP	14557253
Intra	CD151	P48509	ITGA3	Homo sapiens	P26006	Anti Tag CoIP	14557253
Intra	CD151	P48509	GRAMD1C	Homo sapiens	Q8IYS0	Validated Y2H	25910212
Intra	CD151	P48509	GRAMD1C	Homo sapiens	Q8IYS0	Y2H Bait-Prey Pool	25910212
Intra	CD151	P48509	GRAMD1C	Homo sapiens	Q8IYS0	Validated Y2H	25416956
Intra	CD151	P48509	GRAMD1C	Homo sapiens	Q8IYS0	Validated Y2H	32296183
Intra	CD151	P48509	GRAMD1C	Homo sapiens	Q8IYS0	Y2H Prey Pooling	25416956
Intra	CD151	P48509	GRAMD1C	Homo sapiens	Q8IYS0	Y2H Array	32296183
Intra	CD151	P48509	GRAMD1C	Homo sapiens	Q8IYS0	Y2H Array	25910212
Intra	CD151	P48509	GRAMD1C	Homo sapiens	Q8IYS0	Y2H Prey Pooling	32296183
Intra	CD151	P48509	TMEM139	Homo sapiens	Q8IV31	Y2H Prey Pooling	32296183
Intra	CD151	P48509	TMEM139	Homo sapiens	Q8IV31	Validated Y2H	32296183
Intra	CD151	P48509	TMEM139	Homo sapiens	Q8IV31	Y2H Array	32296183
Intra	CD151	P48509	KLRC1	Homo sapiens	P26715	Y2H Array	32296183
Intra	CD151	P48509	KLRC1	Homo sapiens	P26715	Y2H Prey Pooling	32296183
Intra	CD151	P48509	ITGB4	Homo sapiens	P16144	Confocal	10811835
Intra	CD151	P48509	ITGB4	Homo sapiens	P16144	Anti Tag CoIP	33961781
Intra	CD151	P48509	ITGB4	Homo sapiens	P16144	Anti Bait CoIP	10811835

Cross: Cross-species interaction Intra: Intraspecies interaction

CD151 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P84350	CD151 Antibody (YA4047)	IHC-P, FC, ELISA	Human
HY-P84350A	CD151 Antibody (YA4047)(PBS only)	IHC-P, FC, ELISA	Human

Related Diseases

Diseases	Alias
Epidermolysis Bullosa Simplex 7, With Nephropathy And Deafness	Nephropathy With Pretibial Epidermolysis Bullosa And Deafness EBS7 Nephrotic Syndrome-Epidermolysis Bullosa-Sensorineural Deafness Syndrome Ebs With Nephropathy Epidermolysis Bullosa Simplex With Nephropathy Nephrotic Syndrome-Hearing Loss-Epidermolysis Bullosa Syndrome Npebd
Raph Blood Group System	Mer2 Blood Cell Antigen Expression Mer2 Blood Group System, Raph
Epidermolysis Bullosa Simplex	Ebs Epidermolysis Bullosa Intraepidermic Epidermolytic Epidermolysis Bullosa
Thalassemia Minor
Epidermolysis Bullosa	Acantholysis Bullosa Eb
Kindler Syndrome	Poikiloderma Of Kindler Bullous Acrokeratotic Poikiloderma Of Kindler And Weary Congenital Bullous Poikiloderma KNDLRS Poikiloderma, Hereditary Acrokeratotic Poikiloderma, Congenital, With Bullae, Weary Type Kindler'S Syndrome Poikiloderma Congenital With Bullae Weary Type Hereditary Acrokeratotic Poikiloderma Of Kindler-Weary Hereditary Acrokeratotic Poikiloderma Weary Syndrome Poikiloderma Hereditary Acrokeratotic Potassium Deficiency
Retinitis Pigmentosa 44	RP44 Retinitis Pigmentosa, Type 44
Focal Segmental Glomerulosclerosis	Familial Idiopathic Steroid-Resistant Nephrotic Syndrome Focal Glomerulosclerosis Fsgs Segmental Glomerulosclerosis Glomerulosclerosis, Focal Segmental Fgs Focal Glomerular Sclerosis Familial Idiopathic Nephrotic Syndrome Focal Sclerosis With Hyalinosis Glomerulosclerosis, Focal Glomerulosclerosis Focal Glomerulosclerosis, Segmental, Focal Focal Segmental Glomerulosclerosis, Not Otherwise Specified
Transient Bullous Dermolysis Of The Newborn	TBDN Transient Bullous Of The Newborn Epidermolysis Bullosa Dystrophica, Neonatal Form Dystrophic Epidermolysis Bullosa, Neonatal Deb, Bullous Dermolysis Of The Newborn Deb-Bdn Epidermolysis Bullosa Dystrophica, Dominant Neonatal Form Self-Improving Dystrophic Epidermolysis Bullosa Self-Improving Deb Epidermolysis Bullosa Dystrophica Dominant Neonatal Type
Junctional Epidermolysis Bullosa	Epidermolysis Bullosa, Junctional Jeb Epidermolysis Bullosa Atrophicans Congenital Junctional Epidermolysis Bullosa Epidermolysis Bullosa Junctional Junctional Eb - [Epidermolysis Bullosa] Jeb - [Junctional Epidermolysis Bullosa] Lucidolytic Epidermolysis Bullosa
Epidermolysis Bullosa, Junctional 5b, With Pyloric Atresia	Junctional Epidermolysis Bullosa With Pyloric Atresia Carmi Syndrome Epidermolysis Bullosa, Junctional, With Pyloric Atresia Jeb-Pa JEB5B Epidermolysis Bullosa Junctionalis With Pyloric Atresia Aplasia Cutis Congenita With Gastrointestinal Atresia Epidermolysis Bullosa, Junctional, With Pyloric Atresia And Aplasia Cutis Congenita Eb-Pa-Acc Junctional Epidermolysis Bullosa-Pyloric Atresia Syndrome Jeb With Pyloric Atresia Epidermolysis Bullosa Letalis, With Pyloric Atresia Pa-Jeb Epidermolysis Bullosa With Pyloric Atresia
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Tibial Adamantinoma	Tibial Adamantinoma Morphology
Alport Syndrome	Hereditary Nephritis Alport Syndrome, X-Linked Hemorrhagic Hereditary Nephritis Congenital Hereditary Hematuria Hemorrhagic Familial Nephritis Familial Nephritis Thin Basement Membrane Disease Thin Basement Membrane Nephropathy Hematuria-Nephropathy-Deafness Syndrome Hematuric Hereditary Nephritis Hereditary Familial Congenital Hemorrhagic Nephritis Hereditary Hematuria Syndrome Hereditary Interstitial Pyelonephritis Alport Deafness-Nephropathy Alport Hearing Loss-Nephropathy Alports Syndrome Nephritis, Hereditary
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02190	CD151 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17904	Cd151 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24373	Cd151 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CD151	MGD	MGI:1096360
Macaca mulatta	CD151	VGNC	VGNC:100903
Canis familiaris	CD151	VGNC	VGNC:51858
Felis catus	CD151	VGNC	VGNC:81915
Bos taurus	CD151	VGNC	VGNC:53655
Rattus norvegicus	CD151	RGD	RGD:621290
Others	CD151	NCBI