ITGA3 - integrin subunit alpha 3 Gene

Also Known as JEB7; VL3A; CD49C; FRP-2; GAPB3; ILNEB; MSK18; VCA-2; VLA3a; GAP-B3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3675

About ITGA3

Cytogenetic location: 17q21.33 Genomic coordinates (GRCh38): 17:50,056,110-50,090,481 (from NCBI)

This gene has 16 transcripts (splice variants), 286 orthologues, 17 paralogues and is associated with 3 phenotypes. Broad expression in lung (RPKM 53.0), thyroid (RPKM 21.5) and 19 other tissues.

Summary

The gene encodes a member of the Integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function as cell surface adhesion molecules. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 3 subunit. This subunit joins with a beta 1 subunit to form an Integrin that interacts with extracellular matrix proteins including members of the laminin family. Expression of this gene may be correlated with breast Cancer metastasis. [provided by RefSeq, Oct 2015]

ITGA3 Products (1)

mRNA	Protein	Name
NM_002204.4	NP_002195.1	integrin alpha-3 preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protease binding	IPI IPI: Inferred from physical interaction	10455171	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	1911778	GOA
enables protein heterodimerization activity	IDA IDA: Inferred from direct assay	10455171	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in lung development	IMP IMP: Inferred from mutant phenotype	24621570	GOA
involved in mesodermal cell differentiation	IEP IEP: Inferred from expression pattern	23154389	GOA
involved in nephron development	IMP IMP: Inferred from mutant phenotype	24621570	GOA
involved in positive regulation of protein localization to plasma membrane	IDA IDA: Inferred from direct assay	10455171	GOA
involved in regulation of BMP signaling pathway	IMP IMP: Inferred from mutant phenotype	24621570	GOA
involved in regulation of Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	24621570	GOA
involved in regulation of transforming growth factor beta receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	24621570	GOA
involved in renal filtration	IMP IMP: Inferred from mutant phenotype	24621570	GOA
involved in skin development	IMP IMP: Inferred from mutant phenotype	24621570	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cell periphery	IDA IDA: Inferred from direct assay	24220332	GOA
located in cell surface	IDA IDA: Inferred from direct assay	19933311	GOA
located in filopodium membrane	IDA IDA: Inferred from direct assay	10455171	GOA
part of integrin alpha3-beta1 complex	IDA IDA: Inferred from direct assay	25063885	GOA
part of integrin alpha3-beta1 complex	IMP IMP: Inferred from mutant phenotype	24220332	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	21310825	GOA
part of receptor complex	IDA IDA: Inferred from direct assay	23382219	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ITGA3 Protein Structure

VCBS

Integrin_alpha2

0
200
400
600
800
1000
1051 a.a.

Protein Preferred Names	Protein Names
integrin alpha-3	CD49 antigen-like family member C

ITGA3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ITGA3	P26006	CD151	Homo sapiens	P48509	Confocal	14557253
Intra	ITGA3	P26006	LGALS1	Homo sapiens	P09382	Crosslink	30021884

Cross: Cross-species interaction Intra: Intraspecies interaction

ITGA3 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P84216	CD49C Antibody (YA3913)	WB, FC, ELISA	Human
HY-P84216A	CD49C Antibody (YA3913)(PBS only)	WB, FC, ELISA	Human

Related Diseases

Diseases	Alias
Epidermolysis Bullosa, Junctional 7, With Interstitial Lung Disease And Nephrotic Syndrome	JEB7 Interstitial Lung Disease, Nephrotic Syndrome, And Epidermolysis Bullosa, Congenital Ilneb Congenital Nephrotic Syndrome - Interstitial Lung Disease - Epidermolysis Bullosa Syndrome Interstitial Lung Disease-Nephrotic Syndrome-Epidermolysis Bullosa Syndrome Ilneb Syndrome Jeb With Interstitial Lung Disease And Nephrotic Syndrome Junctional Epidermolysis Bullosa With Interstitial Lung Disease And Nephrotic Syndrome Lung Disease, Interstitial, Nephrotic Syndrome, And Epidermolysis Bullosa, Congenital
Mucormycosis	Zygomycosis Disseminated Mucormycosis Absidia Infection Absidia Mucoromycosis Cunninghamella Infection Cunninghamella Mucoromycosis Infection By Absidia Spp Infection By Rhizopus Spp Mucor Infection Mucor Mucoromycosis Infection By Mucor Spp Rhizopus Infection Rhizopus Mucoromycosis Infection By Cunninghamella Spp Phycomycosis Nos
Nephrotic Syndrome	Finnish Congenital Nephrotic Syndrome Ns - [Nephrotic Syndrome] Nephrosis Syndrome Nephrosis Nos Glomerular Lesion Nephrosis
Interstitial Lung Disease	Ild Lung Diseases, Interstitial Lung Diseases Interstitial Interstitial Lung Diseases
Epidermolysis Bullosa	Acantholysis Bullosa Eb
Lung Disease	Lung Diseases Disorder Of Lung Abnormality Of The Lung
Focal Segmental Glomerulosclerosis	Familial Idiopathic Steroid-Resistant Nephrotic Syndrome Focal Glomerulosclerosis Fsgs Segmental Glomerulosclerosis Glomerulosclerosis, Focal Segmental Fgs Focal Glomerular Sclerosis Familial Idiopathic Nephrotic Syndrome Focal Sclerosis With Hyalinosis Glomerulosclerosis, Focal Glomerulosclerosis Focal Glomerulosclerosis, Segmental, Focal Focal Segmental Glomerulosclerosis, Not Otherwise Specified
Fraser Syndrome 1	Fraser Syndrome Cryptophthalmos With Other Malformations Cryptophthalmos Syndrome FRASRS1 Cryptophthalmos-Syndactyly Syndrome Fraser-Francois Syndrome Cyclopism Meyer-Schwickerath'S Syndrome Ulrich-Feichtiger Syndrome Cryptophthalmos Syndactyly Syndrome Fraser'S Syndrome Meyer-Schwickerath Syndrome Ullrich-Feichtiger Syndrome
Hydrocele	Testicular Hydrocele
Villous Adenocarcinoma
Fibrosarcoma	Neoplasms, Fibrous Tissue Fibrocytic Tumor Fibrosarcoma Of Soft Tissue Fibrous Tissue Neoplasm
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Junctional Epidermolysis Bullosa	Epidermolysis Bullosa, Junctional Jeb Epidermolysis Bullosa Atrophicans Congenital Junctional Epidermolysis Bullosa Epidermolysis Bullosa Junctional Junctional Eb - [Epidermolysis Bullosa] Jeb - [Junctional Epidermolysis Bullosa] Lucidolytic Epidermolysis Bullosa
Arrhythmogenic Right Ventricular Cardiomyopathy	Arrhythmogenic Right Ventricular Dysplasia Arvc Arvd Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy Arvc Cardiomyopathy Arrhythmogenic Right Ventricular Cardiomyopathy-Dysplasia Arvd/C Right Ventricular Dysplasia, Arrhythmogenic Ventricular Dysplasia, Right, Arrhythmogenic Cardiomyopathy, Ventricular, Right, Arrhythmogenic Dysplasia, Arrhythmogenic Right Ventricular
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Galloway-Mowat Syndrome	Galloway Mowat Syndrome Galloway Syndrome Hiatal Hernia-Microcephaly-Nephrosis, Galloway Type Microcephaly Nephrosis Syndrome Microcephaly, Hiatal Hernia, And Nephrotic Syndrome Nephrosis Neuronal Dysmigration Syndrome Microcephaly-Hiatus Hernia-Nephrotic Syndrome Nephrosis-Neuronal Dysmigration Syndrome
Alport Syndrome	Hereditary Nephritis Alport Syndrome, X-Linked Hemorrhagic Hereditary Nephritis Congenital Hereditary Hematuria Hemorrhagic Familial Nephritis Familial Nephritis Thin Basement Membrane Disease Thin Basement Membrane Nephropathy Hematuria-Nephropathy-Deafness Syndrome Hematuric Hereditary Nephritis Hereditary Familial Congenital Hemorrhagic Nephritis Hereditary Hematuria Syndrome Hereditary Interstitial Pyelonephritis Alport Deafness-Nephropathy Alport Hearing Loss-Nephropathy Alports Syndrome Nephritis, Hereditary
Basal Cell Carcinoma	Basal Cell Cancer Basal Cell Neoplasm Basal Cell Carcinoma Of Skin Malignant Basal Cell Tumor Basal Cell Tumor Epithelioma Basal Cell Malignant Basal Cell Neoplasm Rodent Ulcer Carcinoma Basal Cell Neoplasms, Basal Cell Basal Cell Carcinomas Experimental Organism Basal Cell Carcinoma Nodulo-Ulcerative Basal Cell Carcinoma Basalioma Basal Cell Epithelioma Of Skin Bcc - [Basal Cell Carcinoma] Of Skin Rodent Ulcer Of Skin Rodent Ulcer Of Unspecified Site Basal Cell Epithelioma Of Unspecified Site

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06950	ITGA3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20968	Itga3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27485	Itga3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	ITGA3	MGD	MGI:96602
Felis catus	ITGA3	VGNC	VGNC:67841
Bos taurus	ITGA3	VGNC	VGNC:30315
Canis familiaris	ITGA3	VGNC	VGNC:42125
Rattus norvegicus	ITGA3	RGD	RGD:1310333
Macaca mulatta	ITGA3	VGNC	VGNC:73777
Others	ITGA3	NCBI