Emd - emerin Gene

Also Known as Sta

Species: Mus musculus

Gene Type: protein coding
Gene ID: 13726

Summary

This gene is the founding member of the LEM (Lap2beta, Emerin, and Man1) domain gene family. It encodes an integral membrane protein of the inner nuclear membrane. This gene may be involved in transcriptional regulation and genomic organization. In humans, mutations in this gene cause a class of diseases called laminopathies, which includes Emery-Dreifuss muscular dystrophy (EDMD). [provided by RefSeq, Apr 2013]

Emd Products (11)

mRNA Protein Name
NM_001410134.1 NP_001397063.1 emerin isoform 2
NM_001410135.1 NP_001397064.1 emerin isoform 2
NM_001410136.1 NP_001397065.1 emerin isoform 3
NM_001410137.1 NP_001397066.1 emerin isoform 4
NM_001410138.1 NP_001397067.1 emerin isoform 4
NM_001410139.1 NP_001397068.1 emerin isoform 4
NM_001410140.1 NP_001397069.1 emerin isoform 5
NM_001410141.1 NP_001397070.1 emerin isoform 6
NM_001410142.1 NP_001397071.1 emerin isoform 7
NM_001410143.1 NP_001397072.1 emerin isoform 8
NM_007927.4 NP_031953.1 emerin isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
19933576 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within skeletal muscle cell differentiation IGI
IGI: Inferred from genetic interaction
19720741 MGI
acts upstream of or within skeletal muscle cell differentiation IMP
IMP: Inferred from mutant phenotype
19720741 MGI
Cellular Component GO Annotation Evidence References Source
located in TMEM240-body IDA
IDA: Inferred from direct assay
32535204 MGI
located in nuclear envelope IDA
IDA: Inferred from direct assay
19933576 MGI
located in nuclear membrane IDA
IDA: Inferred from direct assay
17164264 MGI
located in nucleus IDA
IDA: Inferred from direct assay
22349700 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

emerin

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (8)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-14721 Tepotinib 99.94% Yes
HY-14262 Vilazodone 99.73% Unkown
HY-14261 Vilazodone Hydrochloride 99.94% Unkown
HY-70057 Safinamide Inhibitor 99.86% Yes
HY-14771A Imeglimin hydrochloride 99.98% Unkown
HY-70057A Safinamide mesylate Inhibitor 99.07% Yes
HY-14771 Imeglimin 99.10% Unkown
HY-14721A Tepotinib hydrochloride / Unkown

Clinical Phase

Bioactive Molecules (16)
Cat. No. Product Name Effect
Purity Phase
HY-16141 Cilengitide 99.91% Phase 3
HY-100820 Sarizotan Agonist 98.23% Phase 3
HY-107384 Asimadoline Agonist 99.36% Phase 3
HY-100820B Sarizotan dihydrochloride Agonist / Phase 3
HY-106246 Pruvanserin Antagonist 99.54% Phase 2
HY-136280 Panamesine 99.54% Phase 2
HY-103115 Pruvanserin hydrochloride Antagonist / Phase 2
HY-106100 Roxindole / Phase 2
HY-133931 Bimakalim / Phase 2
HY-19273 Rimeporide Inhibitor 98.63% Phase 1
HY-15000 EMD534085 Inhibitor 99.55% Phase 1
HY-103410 Carmoxirole hydrochloride Agonist 99.82% Phase 1
HY-106844 EMD 53998 Inhibitor 99.59% Phase 1
HY-105112 Carmoxirole Agonist / Phase 1
HY-123356 EMD-503982 Inhibitor / Phase 1
HY-164394 EMD 1204831 Inhibitor / Phase 1
Inhibitory Antibodies (3)
Cat. No. Product Name Effect
Purity Phase
HY-P991214 Tucotuzumab celmoleukin 98.797% Phase 3
HY-P9969 Matuzumab 98.12% Phase 2
HY-P99183 Abituzumab Inhibitor 99.38% Phase 2

Pre-clinical Phase

Bioactive Molecules (43)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-15193 EMD638683 99.94% Unkown
HY-16143 Cilengitide TFA 99.92% Yes
HY-P0322 GRGDSPK Inhibitor 98.55% Unkown
HY-106844A (+)-EMD 57033 99.72% Unkown
HY-101473 EMD527040 Inhibitor 99.88% Unkown
HY-106100A Roxindole hydrochloride 99.48% Unkown
HY-107384A Asimadoline hydrochloride Agonist 99.57% Unkown
HY-106150B Eniporide hydrochloride Inhibitor 99.49% Unkown
HY-14203 (R)-Safinamide Inhibitor 99.89% Unkown
HY-107030 Nitrefazole 99.44% Unkown
HY-170410 EMD-95885 Antagonist 98.74% Unkown
HY-15193B EMD638683 (S-Form) Inhibitor 99.72% Unkown
HY-103130 EMD386088 Agonist 99.06% Unkown
HY-15193A EMD638683 (R-Form) Inhibitor 99.86% Unkown
HY-19134 EMD 56551 Agonist / Unkown
HY-70057S1 Safinamide-d4-1 Inhibitor 98.90% Unkown
HY-19273R Rimeporide (Standard) Inhibitor 98.11% Unkown
HY-100820A Sarizotan hydrochloride Agonist / Unkown
HY-101473A EMD527040 hydrochloride Antagonist / Unkown
HY-103130A EMD 386088 free base Agonist / Unkown
HY-103247 EMD 66684 Antagonist / Unkown
HY-103247B EMD-66684 potassium salt Antagonist / Unkown
HY-105539 EMD 86006 Inhibitor / Unkown
HY-106150A Eniporide mesylate Inhibitor / Unkown
HY-10777 EMD 495235 Inhibitor / Unkown
HY-114987 EMD 21657 Modulator / Unkown
HY-114990 EMD 57439 Inhibitor / Unkown
HY-14262S1 Vilazodone-d8 hydrochloride / Unkown
HY-169827 EMD-132338 Antagonist / Unkown
HY-175878 EMD-C02602 Modulator / Unkown
HY-A0300 Cyclopeptide-5 Antagonist / Unkown
HY-P0322A GRGDSPK TFA Inhibitor / Unkown
HY-P2075 EMD 55068 Antagonist / Unkown
HY-RS04345 EMD Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-106150 Eniporide Inhibitor / Unkown
HY-106472 Tioxaprofen Inhibitor / Unkown
HY-129714 EMD 52297 Inhibitor / Unkown
HY-14771S Imeglimin-d3 / Unkown
HY-19273A Rimeporide hydrochloride Inhibitor / Unkown
HY-70057S4 Safinamide-d5 Inhibitor / Unkown
HY-RS17358 Emd Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23812 Emd Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W705589 Rimeporide-15N3 hydrochloride Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Emd NCBI NCBI:2010