Pruvanserin
Based on 1 Customer Validation
Pruvanserin (EMD 281014 free base) is a selective 5-HT2A receptor antagonist. Pruvanserin alleviates tactile allodynia in diabetic rats. Pruvanserin can also be used for research of insomnia.
For research use only. We do not sell to patients.
- Purity: 99.54%
- CAS No.: 443144-26-1
- Formula: C22H21FN4O
- Molecular Weight:376.43
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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All 5-HT Receptor Isoforms
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Biological Activity
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5-HT2A Receptor |
Chemical Information
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CAS No. 443144-26-1
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Appearance Solid
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Molecular Weight 376.43
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Formula C22H21FN4O
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Color Off-white to light yellow
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SMILES
N#CC1=CNC2=C1C=CC=C2C(N3CCN(CC3)CCC4=CC=C(C=C4)F)=O
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Synonyms
EMD 281014 free base; LY 2422347
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : ≥ 100 mg/mL (265.65 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Abbas A, et al. Pimavanserin tartrate: a 5-HT2A inverse agonist with potential for treating various neuropsychiatric disorders. Expert Opin Pharmacother. 2008 Dec;9(18):3251-9. [Content Brief]
[2]. Mixcoatl-Zecuatl T, et al. A spinal mechanism of action for duloxetine in a rat model of painful diabetic neuropathy. Br J Pharmacol. 2011 Sep;164(1):159-69. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.6565 mL | 13.2827 mL | 26.5654 mL | 66.4134 mL |
| 5 mM | 0.5313 mL | 2.6565 mL | 5.3131 mL | 13.2827 mL | |
| 10 mM | 0.2657 mL | 1.3283 mL | 2.6565 mL | 6.6413 mL | |
| 15 mM | 0.1771 mL | 0.8855 mL | 1.7710 mL | 4.4276 mL | |
| 20 mM | 0.1328 mL | 0.6641 mL | 1.3283 mL | 3.3207 mL | |
| 25 mM | 0.1063 mL | 0.5313 mL | 1.0626 mL | 2.6565 mL | |
| 30 mM | 0.0886 mL | 0.4428 mL | 0.8855 mL | 2.2138 mL | |
| 40 mM | 0.0664 mL | 0.3321 mL | 0.6641 mL | 1.6603 mL | |
| 50 mM | 0.0531 mL | 0.2657 mL | 0.5313 mL | 1.3283 mL | |
| 60 mM | 0.0443 mL | 0.2214 mL | 0.4428 mL | 1.1069 mL | |
| 80 mM | 0.0332 mL | 0.1660 mL | 0.3321 mL | 0.8302 mL | |
| 100 mM | 0.0266 mL | 0.1328 mL | 0.2657 mL | 0.6641 mL |
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