Sarizotan dihydrochloride
Based on 1 publication(s) in Google Scholar
Sarizotan dihydrochloride (EMD 128130) is an orally active serotonin 5-HT1A receptor and dopamine receptor agonist. Sarizotan (EMD 128130) exhibits IC50 values of 6.5 nM (rat 5-HT1A), 0.1 nM (human 5-HT1A), 15.1 nM (rat D2), 17 nM (human D2), 6.8 nM (human D3) and 2.4 nM (human D4.2), respectively.
For research use only. We do not sell to patients.
- CAS No.: 177976-12-4
- Formula: C22H23Cl2FN2O
- Molecular Weight:421.34
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Sarizotan dihydrochloride
MoreAll 5-HT Receptor Isoforms
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Biological Activity
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5-HT1A Receptor 0.1 nM (IC50) |
5-HT1A Receptor |
Human D3 Receptor 6.8 nM (IC50) |
5-HT2A Receptor 587 nM (IC50) |
5-HT2B Receptor 108 nM (IC50) |
5-HT5A Receptor 313 nM (IC50) |
Human 5-HT6 Receptor 3300 nM (IC50) |
Human 5-HT7 Receptor 10 nM (IC50) |
Chemical Information
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CAS No. 177976-12-4
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Molecular Weight 421.34
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Formula C22H23Cl2FN2O
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SMILES
FC(C=C1)=CC=C1C2=CN=CC(CNC[C@@H]3OC4=CC=CC=C4CC3)=C2.Cl.Cl
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Synonyms
EMD 128130 dihydrochloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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Cell Death Dis
MAL2 reprograms lipid metabolism in intrahepatic cholangiocarcinoma via EGFR/SREBP-1 pathway based on single-cell RNA sequencing. [Abstract]2024 Jun 12;15(6):411. PMID: 38866777
Purity & Documentation
References
[1]. G D Bartoszyk, et al. Sarizotan, a Serotonin 5-HT1A Receptor Agonist and Dopamine Receptor Ligand. J Neural Transm (Vienna). 2004 Feb;111(2):113-26. [Content Brief]
[2]. C Marin, et al. Local Administration of Sarizotan Into the Subthalamic Nucleus Attenuates Levodopa-Induced Dyskinesias in 6-OHDA-lesioned Rats. Psychopharmacology (Berl). 2009 Jun;204(2):241-50. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Sarizotan dihydrochloride Related Classifications
HY-100820B Related Classifications
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