(R)-Safinamide
Based on 1 Customer Validation
(R)-Safinamide (FCE 28073) is the enantiomer of Safinamide (HY-70057). (R)-Safinamide is an orally active, alanine-derived monoamine oxidase inhibitor with an IC50 of 1.77 μM for rat MAO-B and an IC50 of 50 μM for rat MAO-A. (R)-Safinamide regulates the activity of monoamine oxidase isoforms in brain homogenates. (R)-Safinamide is used in epilepsy research.
For research use only. We do not sell to patients.
- Purity : 99.89%
- CAS No.: 174756-44-6
- Formula: C17H19FN2O2
- Molecular Weight:302.34
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocols
- Purity & Documentation
- References
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Help & FAQs
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HY-70057
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Azure BMAO-A Inhibitor -
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Ro 41-1049 hydrochlorideMAO-A Inhibitor
Biological Activity
Description
IC50 & Target
[1]|
rMAO-B 1.77 μM (IC50) |
rMAO-A 50 μM (IC50) |
In Vitro
(R)-Safinamide (FCE 28073) (2 min) inhibits rat brain MAO-B with an IC50 of 1.77 μM and exhibits greater MAO-B inhibitory potency relative to its MAO-A activity[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Sprague-Dawley (male; 200-230 g body weight)[1]
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Dosage:1 mg/kg (MAO-A inhibition 0%; MAO-B inhibition 2%); 5 mg/kg (MAO-A inhibition 0%; MAO-B inhibition 11%); 10 mg/kg (MAO-A inhibition 0%; MAO-B inhibition 33%); 60 mg/kg (MAO-A inhibition 0%; MAO-B inhibition 50%)
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Administration:p.o.; single dose
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Result:Showed 0% MAO-A inhibition at 1 mg/kg.
Showed 0% MAO-A inhibition at 5 mg/kg.
Showed 0% MAO-A inhibition at 10 mg/kg.
Showed 0% MAO-A inhibition at 60 mg/kg.
Showed 2% MAO-B inhibition at 1 mg/kg.
Showed 11% MAO-B inhibition at 5 mg/kg.
Showed 33% MAO-B inhibition at 10 mg/kg.
Showed 50% MAO-B inhibition at 60 mg/kg.
Chemical Information
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CAS No. 174756-44-6
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Appearance Solid
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Molecular Weight 302.34
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Formula C17H19FN2O2
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Color White to off-white
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SMILES
FC1=CC=CC(COC2=CC=C(C=C2)CN[C@@H](C(N)=O)C)=C1
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Synonyms
FCE 28073; (R)-EMD 1195686
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
In Vitro:
DMSO : ≥ 125 mg/mL (413.44 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
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Data Sheet (276 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.3075 mL | 16.5377 mL | 33.0753 mL | 82.6884 mL |
| 5 mM | 0.6615 mL | 3.3075 mL | 6.6151 mL | 16.5377 mL | |
| 10 mM | 0.3308 mL | 1.6538 mL | 3.3075 mL | 8.2688 mL | |
| 15 mM | 0.2205 mL | 1.1025 mL | 2.2050 mL | 5.5126 mL | |
| 20 mM | 0.1654 mL | 0.8269 mL | 1.6538 mL | 4.1344 mL | |
| 25 mM | 0.1323 mL | 0.6615 mL | 1.3230 mL | 3.3075 mL | |
| 30 mM | 0.1103 mL | 0.5513 mL | 1.1025 mL | 2.7563 mL | |
| 40 mM | 0.0827 mL | 0.4134 mL | 0.8269 mL | 2.0672 mL | |
| 50 mM | 0.0662 mL | 0.3308 mL | 0.6615 mL | 1.6538 mL | |
| 60 mM | 0.0551 mL | 0.2756 mL | 0.5513 mL | 1.3781 mL | |
| 80 mM | 0.0413 mL | 0.2067 mL | 0.4134 mL | 1.0336 mL | |
| 100 mM | 0.0331 mL | 0.1654 mL | 0.3308 mL | 0.8269 mL |
(R)-Safinamide Related Classifications
HY-14203 Related Classifications
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