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Cat. No.: HY-175878

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EMD-C02602

EMD-C02602 is a GCN2-targeting agent with IC₅₀ values of 0.023 μM, 4.52 μM, ＞ 10 μM and 0.048 μM for GCN2, PERK, HRland PKR, respectively.

For research use only. We do not sell to patients.

Formula: C₁₉H₂₁F₄N₇O₂S
Molecular Weight:487.47

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

EMD-C02602 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

EMD-C02602 is a GCN2-targeting agent with IC₅₀ values of 0.023 μM, 4.52 μM, ＞ 10 μM and 0.048 μM for GCN2, PERK, HRland PKR, respectively^[1].

In Vitro

EMD-C02602 (0–10 μM, 72 h) exhibits a U-shaped viability response in MOLM-16 cells, , causing the most significant decrease in cell viability at intermediate concentrations (around 0.05 μM), while showing reduced inhibitory effects at both lower and higher concentrations^[1].
EMD-C02602 (0.05-0.12 μM, 8 h) increases the expression of ATF4 ^[1].
EMD-C02602 (0.5-1.1 μM, 8 h) increases the expression of p-GCN2 while shows no effect on the expression of GCN2 ^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Chemical Information

Molecular Weight 487.47
Formula C₁₉H₂₁F₄N₇O₂S
SMILES

O=S(NC[C@@H]1CN(C2=NC=NC(C3=CN=C4C=CC(C(F)F)=NN43)=C2)C[C@H](C)C1(F)F)(C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Tameire F, et al. In Vivo Tumor Growth Control by General Control Nonderepressible 2-Targeting Agents Results from Kinase Activation. Mol Cancer Ther. 2025 Sep 5:OF1-OF13. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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