2. Cell Cycle/DNA Damage
  3. Eukaryotic Initiation Factor (eIF)
  4. EMD-C02602

EMD-C02602 is a GCN2-targeting agent with IC50 values of 0.023 μM, 4.52 μM, ＞ 10 μM and 0.048 μM for GCN2, PERK, HRland PKR, respectively.

For research use only. We do not sell to patients.

EMD-C02602

EMD-C02602 Chemical Structure

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

EMD-C02602 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

EMD-C02602 is a GCN2-targeting agent with IC50 values of 0.023 μM, 4.52 μM, ＞ 10 μM and 0.048 μM for GCN2, PERK, HRland PKR, respectively[1].

In Vitro

EMD-C02602 (0–10 μM, 72 h) exhibits a U-shaped viability response in MOLM-16 cells, , causing the most significant decrease in cell viability at intermediate concentrations (around 0.05 μM), while showing reduced inhibitory effects at both lower and higher concentrations[1].
EMD-C02602 (0.05-0.12 μM, 8 h) increases the expression of ATF4 [1].
EMD-C02602 (0.5-1.1 μM, 8 h) increases the expression of p-GCN2 while shows no effect on the expression of GCN2 [1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

EMD-C02602 Related Antibodies
Molecular Weight

487.47

Formula

C19H21F4N7O2S
SMILES

O=S(NC[C@@H]1CN(C2=NC=NC(C3=CN=C4C=CC(C(F)F)=NN43)=C2)C[C@H](C)C1(F)F)(C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

EMD-C02602 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EMD-C02602Eukaryotic Initiation Factor (eIF)MOLM-16 cellsInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
EMD-C02602
Cat. No.:
HY-175878
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.