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MAFG - MAF bZIP transcription factor G Gene

Also Known as hMAF

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 4097

About MAFG

Cytogenetic location: 17q25.3 Genomic coordinates (GRCh38): 17:81,918,270-81,931,244 (from NCBI)

This gene has 3 transcripts (splice variants), 262 orthologues and 6 paralogues. Ubiquitous expression in bone marrow (RPKM 12.5), brain (RPKM 8.7) and 25 other tissues.

Summary

Globin gene expression is regulated through nuclear factor erythroid-2 (NFE2) elements located in enhancer-like locus control regions positioned many kb upstream of alpha- and beta-gene clusters (summarized by Blank et al., 1997 [PubMed 9166829]). NFE2 DNA-binding activity consists of a heterodimer containing a ubiquitous small Maf protein (MafF, MIM 604877; MafG; or MafK, MIM 600197) and the tissue-restricted protein p45 NFE2 (MIM 601490). Both subunits are members of the activator protein-1-like superfamily of basic leucine zipper (bZIP) proteins (see MIM 165160).[supplied by OMIM, Mar 2010]

MAFG Products (2)

mRNA	Protein	Name
NM_002359.4	NP_002350.1	transcription factor MafG
NM_032711.4	NP_116100.2	transcription factor MafG

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	20102225	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	8932385	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of RNA polymerase II transcription regulator complex	IPI IPI: Inferred from physical interaction	23661758	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MAFG Protein Structure

bZIP_Maf

0
100
162 a.a.

Protein Preferred Names	Protein Names
transcription factor MafG	basic leucine zipper transcription factor MafG

MAFG Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	MAFG	O15525	BATF3	Homo sapiens	Q9NR55	FRET	23661758
Intra	MAFG	O15525	NFE2L3	Homo sapiens	Q9Y4A8	FRET	23661758
Intra	MAFG	O15525	NFE2L1	Homo sapiens	Q14494-2	SLC	31467278
Intra	MAFG	O15525	BACH1	Homo sapiens	O14867	Peptide Array	20102225
Intra	MAFG	O15525	BACH1	Homo sapiens	O14867	FRET	23661758
Intra	MAFG	O15525	BACH2	Homo sapiens	Q9BYV9	Y2H Prey Pooling	32296183
Intra	MAFG	O15525	BACH2	Homo sapiens	Q9BYV9	Validated Y2H	32296183
Intra	MAFG	O15525	BACH2	Homo sapiens	Q9BYV9	FRET	23661758
Intra	MAFG	O15525	BACH2	Homo sapiens	Q9BYV9	Y2H Array	32296183
Intra	MAFG	O15525	NFE2L2	Homo sapiens	Q16236	Y2H Prey Pooling	32296183
Intra	MAFG	O15525	NFE2L2	Homo sapiens	Q16236	Complementation	32296183
Intra	MAFG	O15525	NFE2L2	Homo sapiens	Q16236	Validated Y2H	32296183
Intra	MAFG	O15525	NFE2L2	Homo sapiens	Q16236	MAPPIT	25416956
Intra	MAFG	O15525	NFE2L2	Homo sapiens	Q16236	FRET	23661758
Intra	MAFG	O15525	NFE2L2	Homo sapiens	Q16236	Y2H Array	32296183
Intra	MAFG	O15525	NFE2L2	Homo sapiens	Q16236	Y2H Pooling	18692475
Intra	MAFG	O15525	NFE2L2	Homo sapiens	Q16236	Y2H	21988832
Intra	MAFG	O15525	NFE2L1	Homo sapiens	Q14494	FRET	23661758
Intra	MAFG	O15525	NFIL3	Homo sapiens	Q16649	FRET	23661758
Intra	MAFG	O15525	MAFF	Homo sapiens	Q9ULX9	FRET	23661758
Cross	MAFG	O15525	HBZ	Human T-cell leukemia virus 1	P0C746	Peptide Array	20102225

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Homocystinuria-Megaloblastic Anemia Cble Type	Functional Methionine Synthase Deficiency Type Cble Hmae Homocystinuria-Megaloblastic Anemia Due To Defect In Cobalamin Metabolism Cble Complementation Type Methylcobalamin Deficiency, Cble Type Vitamin B12-Responsive Homocystinuria, Cble Type
Fibrosarcoma	Neoplasms, Fibrous Tissue Fibrocytic Tumor Fibrosarcoma Of Soft Tissue Fibrous Tissue Neoplasm
Clear Cell Acanthoma	Acanthoma Pale Acanthoma Acanthoma, Clear Cell
Ayme-Gripp Syndrome	AYGRP Cataracts, Congenital, With Sensorineural Deafness, Down Syndrome-Like Facial Appearance, Short Stature, And Mental Retardation Aymé-Gripp Syndrome Fine-Lubinsky Syndrome Brachycephaly-Deafness-Cataract-Intellectual Disability Syndrome Brachycephaly-Hearing Loss-Cataract-Intellectual Disability Syndrome
Anemia, Congenital Dyserythropoietic, Type Ia	Congenital Dyserythropoietic Anemia Type I Cda I CDAN1A Congenital Dyserythropoietic Anemia Type 1 Congenital Dyserythropoietic Anemia Type Ia Congenital Dyserythropoietic Anemia, Type I Anemia, Congenital Dyserythropoietic, Type I Cda Type 1 Cda Type I Cda Ia Dyserythropoietic Anemia, Congenital Type 1 Anemia, Congenital Dyserythropoietic, Type 1a Dyserythropoietic Anemia, Congenital, Type Ia Cda, Type Ia Congenital Dyserythropoietic Anaemia Type 1 Congenital Dyserythropoietic Anaemia Type I Anemia, Dyserythropoietic, Congenital Type 1 Type I Congenital Dyserythropoietic Anemia Anemia, Congenital Dyserythropoietic, 1a Anemia, Dyserythropoietic, Congenital, Type Ia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07961	MAFG Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS16288	Mafg Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS23911	Mafg Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	MAFG	VGNC	VGNC:42921
Bos taurus	MAFG	VGNC	VGNC:31141
Felis catus	MAFG	VGNC	VGNC:99208
Mus musculus	MAFG	MGD	MGI:96911
Rattus norvegicus	MAFG	RGD	RGD:619953
Macaca mulatta	MAFG	VGNC	VGNC:74474
Others	MAFG	NCBI