230640-88-7
Chemical Structure
BMS-284640
- CAS 番号: 230640-88-7
- Formula:C15H19N3O2
- Molecular Weight:273.33
IUPAC Name: (1R,3R)-N-carbamimidoyl-3-(2,3-dihydrobenzofuran-4-yl)-2,2-dimethylcyclopropane-1-carboxamide
InChIKey: BSKQEHDSFIRYHK-NEPJUHHUSA-N
SMILES: O=C([C@H]1C(C)(C)[C@@H]1C2=C3CCOC3=CC=C2)NC(N)=N
Biological Activity: BMS-284640 is a synthetic sodium hydrogen exchange isomer-1 (NHE-1) inhibitor. BMS-284640 has a more than 380-fold higher NHE-1 inhibitory activity (IC50: 9 nM) compared to cariporide (HY-19693) and is more selective for NHE-1 over NHE-2 (IC50: 1.8 μM) and NHE-5 (IC50: 3.36 μM). BMS-284640 and its analogs also exhibit enhanced oral bioavailability and prolonged plasma half-life in rats.[1].
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BMS-284640 | 99.75% | BMS-284640 is a synthetic sodium hydrogen exchange isomer-1 (NHE-1) inhibitor. BMS-284640 has a more than 380-fold higher NHE-1 inhibitory activity (IC50: 9 nM) compared to cariporide (HY-19693) and is more selective for NHE-1 over NHE-2 (IC50: 1.8 μM) and NHE-5 (IC50: 3.36 μM). BMS-284640 and its analogs also exhibit enhanced oral bioavailability and prolonged plasma half-life in rats.. | ||||||||||||||||||||
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