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製品番号: HY-117677

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Cdc7-IN-21

Cdc7-IN-21 (compound 10c) is a potent and selective Cdc7 inhibitor with an IC₅₀ of 0.07 nM. Cdc7-IN-21 can be used to study cancer.

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CAS 番号: 1330781-04-8
分子式: C₁₅H₁₇N₅OS
分子量:315.39

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

Cdc7-IN-21 構造式

CAS 番号: 1330781-04-8

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Cdc7-IN-21 (compound 10c) is a potent and selective Cdc7 inhibitor with an IC₅₀ of 0.07 nM. Cdc7-IN-21 can be used to study cancer^[1].

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Cellular Effect

Cell Line	Type	Value	Description	References
COLO 205	EC₅₀	1100 nM Compound: 10c	Cytotoxicity against human COLO205 cells after 3 days by CellTiter-Glo luminescent cell viability assay Cytotoxicity against human COLO205 cells after 3 days by CellTiter-Glo luminescent cell viability assay	[PMID: 28533114]
COLO 205	EC₅₀	1100 nM Compound: Cpd I	Antiproliferative activity against human COLO205 cells assessed as reduction in cell growth after 3 days by CellTiter-Glo luminescence assay Antiproliferative activity against human COLO205 cells assessed as reduction in cell growth after 3 days by CellTiter-Glo luminescence assay	[PMID: 31895562]
HeLa	IC₅₀	250 nM Compound: 10c	Inhibition of Cdc7 in human HeLa cells assessed as reduction in MCM2 phosphorylation at ser40 residues after 7 hrs by Western blot analysis Inhibition of Cdc7 in human HeLa cells assessed as reduction in MCM2 phosphorylation at ser40 residues after 7 hrs by Western blot analysis	[PMID: 28533114]
HeLa	IC₅₀	250 nM Compound: Cpd I	Inhibition of CDC7 in human HeLa cells assessed as inhibition of MCM2 phosphorylation at Ser40 residue in human HeLa cells after 7 hrs by Western blot analysis Inhibition of CDC7 in human HeLa cells assessed as inhibition of MCM2 phosphorylation at Ser40 residue in human HeLa cells after 7 hrs by Western blot analysis	[PMID: 31895562]

化学情報

CAS 番号 1330781-04-8
分子量 315.39
分子式 C₁₅H₁₇N₅OS
SMILES

O=C1N=C(CN2CCCC2)NC3=C1SC(C4=CNN=C4C)=C3
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (266 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Kurasawa O, et al. 2-Aminomethylthieno [3, 2-d] pyrimidin-4 (3H)-ones bearing 3-methylpyrazole hinge binding moiety: Highly potent, selective, and time-dependent inhibitors of Cdc7 kinase[J]. Bioorganic & Medicinal Chemistry, 2017, 25(14): 3658-3670.

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モル濃度計算機

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濃度 _(終了) 濃度 _(終了)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Cdc7-IN-21

CDK アイソフォーム固有の製品をすべて表示

生物活性

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

Cdc7-IN-21 関連分類

HY-117677 関連分類