CH0076989
CH0076989 is a specific CCR3 agonist. CH0076989 activates eosinophils and transfectants expressing both wild-type CCR3 and a CCR1:CCR3 chimaeric receptor lacking the CCR3 amino-terminus. CH0076989 has a direct interaction with the transmembrane helices of CCR3, supported by the complete loss of its activity due to mutations of the residues Y41, Y113 and E287. CH0076989 can be used for the study of inflammation and allergic diseases (such as asthma).
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- CAS 番号: 954371-52-9
- 分子式: C24H22Br2N2O2
- 分子量:530.25
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
CH0076989 (0.01-10 μM, 4 min) induces eosinophil shape change in a dose dependent manner[1].
CH0076989 (0.0001-10 μM, 5 h) elicits chemotaxis in CCR3-transfected L1.2 cells with an optimal concentration of 1 μM, but has no effect on CCR1-transfected cells[1].
CH0076989 (10 μM, 20 min) induces CCR3 internalization in CCR3-transfected L1.2 cells, which is dose-dependently inhibited by cis-J-113863 (UCB35625) (HY-103360A)[1].
CH0076989 (0.0001-10 μM, 5 h) induces chemotaxis in L1.2 cells transfected with the CCR1:CCR3 chimeric receptor (Chi-1)[1].
CH0076989 (0.0001-10 μM, 5 h) fails to induce chemotaxis in L1.2 cells transfected with Y41A, Y113A, or E287Q mutant CCR3[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 954371-52-9
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分子量 530.25
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分子式 C24H22Br2N2O2
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SMILES
BrC1=CC(NC(CC2=C3C=COC3=CC=C2)=O)=CC=[N+]1CCCC4=CC=CC=C4.[Br-]
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
CH0076989 関連分類
HY-136881 関連分類
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