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Cat. No.: HY-103360A

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cis-J-113863

Name: cis-J-113863
Brand: MedChemExpress
SKU: HY-103360A
Price: 301.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(Synonyms: UCB35625)

cis-J-113863 is a competitive chemokine receptor 1 (CCR1) antagonist, with IC₅₀ values of 0.9 and 5.8 nM for human and mouse CCR1 receptors, respectively.

For research use only. We do not sell to patients.

CAS No.: 202796-41-6
Formula: C₃₀H₃₇Cl₂IN₂O₂
Molecular Weight:655.44

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

cis-J-113863 Chemical Structure

CAS No.: 202796-41-6

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

cis-J-113863 is a competitive chemokine receptor 1 (CCR1) antagonist, with IC₅₀ values of 0.9 and 5.8 nM for human and mouse CCR1 receptors, respectively^[1].

All CCR Isoforms :

Chemical Information

CAS No. 202796-41-6
Molecular Weight 655.44
Formula C₃₀H₃₇Cl₂IN₂O₂
SMILES

CC[N@@+]1(C/C2=C/CCCCCC2)CC[C@H](NC(C3C4=C(OC5=C3C=C(Cl)C=C5)C=CC(Cl)=C4)=O)CC1.[I-]
Synonyms

UCB35625
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. M Amat, et al. Pharmacological blockade of CCR1 ameliorates murine arthritis and alters cytokine networks in vivo. Br J Pharmacol. 2006 Nov;149(6):666-75. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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