CDH16 - cadherin 16 Gene
生物種: Homo sapiens
About CDH16
Restricted expression toward kidney (RPKM 177.1).
Summary
This gene is a member of the Cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. Mapped to a previously identified cluster of Cadherin genes on chromosome 16q22.1, the gene localizes with superfamily members CDH1, CDH3, CDH5, CDH8 and CDH11. The protein consists of an extracellular domain containing 6 Cadherin domains, a transmembrane region and a truncated cytoplasmic domain but lacks the prosequence and tripeptide HAV adhesion recognition sequence typical of most classical Cadherins. Expression is exclusively in kidney, where the protein functions as the principal mediator of homotypic cellular recognition, playing a role in the morphogenic direction of tissue development. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Mar 2011]
CDH16 Products (4)
| mRNA | Protein | Name |
|---|---|---|
| NM_001204744.2 | NP_001191673.1 | cadherin-16 isoform 2 precursor |
| NM_001204745.2 | NP_001191674.1 | cadherin-16 isoform 3 precursor |
| NM_001204746.2 | NP_001191675.1 | cadherin-16 isoform 4 precursor |
| NM_004062.4 | NP_004053.1 | cadherin-16 isoform 1 precursor |
| Molecular Function GO Annotation | Evidence | 参考文献 | 由来 |
|---|---|---|---|
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
32814053 | GOA |
CDH16 Protein Structure
Cadherin: Cadherin domain (133 - 231)
Cadherin: Cadherin domain (267 - 324)
Cadherin: Cadherin domain (342 - 439)
Cadherin: Cadherin domain (457 - 555)
- 0
- 200
- 400
- 600
- 829 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
cadherin-16 |
|
Recombinant CDH16 Proteins
| 製品番号 | 製品名 | アクセッション番号 | 純度 |
|---|---|---|---|
| HY-P73507 | CDH16 Protein, Human (HEK293, His) | O75309/NP_004053.1 (K19-A786) | ≥ 95%, as determined by reducing SDS-PAGE. |
CDH16 抗体
| 製品番号 | 製品名 | アプリケーション | 反応性 |
|---|---|---|---|
| HY-P81731 | Cadherin 16 Antibody (YA1476) | WB, IHC-P, IP | Human, Mouse |
| HY-P85997 | Cadherin 16 Antibody (YA5689) | IHC-P, ICC/IF, ELISA | Human, Mouse |
関連疾患
| Diseases | Alias | |
|---|---|---|
| Oncocytoma |
|
|
| Renal Cell Carcinoma, Nonpapillary |
|
|
| Eosinophilic Variant Of Chromophobe Renal Cell Carcinoma |
|
|
| Renal Oncocytoma |
|
|
| Multilocular Clear Cell Renal Cell Carcinoma |
|
|
| Fetal Adenoma |
|
|
| Epithelial Predominant Wilms' Tumor |
|
|
| Kidney Benign Neoplasm |
|
|
| Collecting Duct Carcinoma |
|
|
| Renal Adenoma |
|
|
| Birt-Hogg-Dube Syndrome |
|
|
| Chromophobe Renal Cell Carcinoma |
|
|
| Renal Cell Carcinoma, Papillary, 1 |
|
|
Related Agents
- Pre-clinical Phase
Pre-clinical Phase
| 製品番号 | 製品名 |
製品効果
|
純度 |
Rare Diseases
|
|---|---|---|---|---|
| HY-RS02327 | CDH17 Human Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
| HY-RS02326 | CDH16 Human Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
| HY-RS17905 | Cdh16 Mouse Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
| HY-RS24374 | Cdh16 Rat Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
Orthologs Information
| 生物種 | Symbol | 由来 | ID |
|---|---|---|---|
| Felis catus | CDH16 | VGNC | VGNC:60674 |
| Macaca mulatta | CDH16 | VGNC | VGNC:70809 |
| Rattus norvegicus | CDH16 | RGD | RGD:1311638 |
| Mus musculus | CDH16 | MGD | MGI:106671 |
| Canis familiaris | CDH16 | VGNC | VGNC:39024 |
| Bos taurus | CDH16 | VGNC | VGNC:27095 |
| Others | CDH16 | NCBI |
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