MOCS3 - molybdenum cofactor synthesis 3 Gene

Also Known as UBA4

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 27304

About MOCS3

Cytogenetic location: 20q13.13 Genomic coordinates (GRCh38): 20:50,958,818-50,963,929 (from NCBI)

This gene has 1 transcript (splice variant), 195 orthologues and 9 paralogues.

Summary

Molybdenum cofactor (MoCo) is necessary for the function of all molybdoenzymes. The protein encoded by this gene adenylates and activates molybdopterin synthase, an enzyme required for biosynthesis of MoCo. This gene contains no introns. A pseudogene of this gene is present on chromosome 14. [provided by RefSeq, Nov 2012]

MOCS3 Products (1)

mRNA Protein Name
NM_014484.5 NP_055299.1 adenylyltransferase and sulfurtransferase MOCS3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables URM1 activating enzyme activity IDA
IDA: Inferred from direct assay
19017811 GOA
enables molybdopterin-synthase sulfurtransferase activity IDA
IDA: Inferred from direct assay
15073332 GOA
enables molybdopterin-synthase sulfurtransferase activity IMP
IMP: Inferred from mutant phenotype
15073332 GOA
enables nucleotidyltransferase activity IDA
IDA: Inferred from direct assay
19017811 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
18650437 GOA
enables sulfurtransferase activity IDA
IDA: Inferred from direct assay
15910006 GOA
enables sulfurtransferase activity IMP
IMP: Inferred from mutant phenotype
17459099 GOA
Biological Process GO Annotation Evidence 参考文献 由来
involved in Mo-molybdopterin cofactor biosynthetic process IDA
IDA: Inferred from direct assay
15073332 GOA
involved in Mo-molybdopterin cofactor biosynthetic process IMP
IMP: Inferred from mutant phenotype
30817134 GOA
involved in molybdopterin cofactor metabolic process IDA
IDA: Inferred from direct assay
18650437 GOA
involved in tRNA thio-modification IDA
IDA: Inferred from direct assay
19017811 GOA
involved in tRNA thio-modification IMP
IMP: Inferred from mutant phenotype
30817134 GOA
involved in tRNA wobble uridine modification IDA
IDA: Inferred from direct assay
19017811 GOA
Cellular Component GO Annotation Evidence 参考文献 由来
located in cytoplasm IDA
IDA: Inferred from direct assay
23593335 GOA
located in cytosol IDA
IDA: Inferred from direct assay
15073332 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MOCS3 Protein Structure

ThiF

ThiF: ThiF family (85 - 213)

(219 - 303)

Rhodanese

Rhodanese: Rhodanese-like domain (351 - 451)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 460 a.a.
Protein Preferred Names Protein Names

adenylyltransferase and sulfurtransferase MOCS3

  • MPT synthase sulfurylase

MOCS3 Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
MOCS3 O95396 TARDBP Homo sapiens Q13148
Validated Y2H
32814053
Intra
MOCS3 O95396 TARDBP Homo sapiens Q13148
Y2H Array
32814053
Intra
MOCS3 O95396 TARDBP Homo sapiens Q13148
Y2H Pooling
32814053
Intra
MOCS3 O95396 ATXN1 Homo sapiens P54253
Y2H Pooling
32814053
Intra
MOCS3 O95396 ATXN1 Homo sapiens P54253
Validated Y2H
32814053
Intra
MOCS3 O95396 ATXN1 Homo sapiens P54253
Y2H Array
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

関連疾患

Diseases Alias
Molybdenum Cofactor Deficiency

  • Combined Molybdoflavoprotein Enzyme Deficiency

  • Mocod

  • Combined Deficiency Of Sulfite Oxidase, Xanthine Dehydrogenase, And Aldehyde Oxidase

  • Combined Deficiency Of Sulfite Oxidase, Xanthine Dehydrogenase And Aldehyde Oxidase

  • Combined Xanthine Oxidase And Sulfite Oxidase And Aldehyde Oxidase Deficiency

  • Deficiency Of Molybdenum Cofactor

  • Deficiency, Molybdenum Cofactor
Molybdenum Cofactor Deficiency, Complementation Group C

  • MOCODC

  • Sulfite Oxidase Deficiency Due To Molybdenum Cofactor Deficiency Type C

  • Molybdenum Cofactor Deficiency C

  • Molybdenum Cofactor Deficiency Type C

  • Combined Deficiency Of Sulfite Oxidase, Xanthine Dehydrogenase And Aldehyde Oxidase Type C

  • Mocod Type C

  • Molybdenum Cofactor Deficiency Complementation Group C

  • Deficiency, Molybdenum Cofactor, Complementation Group C
Sulfite Oxidase Deficiency, Isolated

  • Sulfite Oxidase Deficiency

  • Sulfocysteinuria

  • Isolated Sulfite Oxidase Deficiency

  • ISOD

  • Encephalopathy Due To Sulfite Oxidase Deficiency
Molybdenum Cofactor Deficiency, Complementation Group A

  • MOCODA

  • Sulfite Oxidase Deficiency Due To Molybdenum Cofactor Deficiency Type A

  • Molybdenum Cofactor Deficiency A

  • Molybdenum Cofactor Deficiency Type A

  • Combined Deficiency Of Sulfite Oxidase, Xanthine Dehydrogenase And Aldehyde Oxidase Type A

  • Mocod Type A

  • Combined Deficiency Of Sulfite Oxidase, Xanthine Dehydrogenase, And Aldehyde Oxidase

  • Sulfite Oxidase, Xanthine Dehydrogenase, And Aldehyde Oxidase, Combined Deficiency Of

  • Molybdenum Cofactor Deficiency Complementation Group A

  • Molybdenum Cofactor Deficiency, Type A

  • Deficiency, Molybdenum Cofactor, Complementation Group A
Molybdenum Cofactor Deficiency, Complementation Group B

  • MOCODB

  • Sulfite Oxidase Deficiency Due To Molybdenum Cofactor Deficiency Type B

  • Molybdenum Cofactor Deficiency B

  • Molybdenum Cofactor Deficiency Type B

  • Combined Deficiency Of Sulfite Oxidase, Xanthine Dehydrogenase And Aldehyde Oxidase Type B

  • Mocod Type B

  • Molybdenum Cofactor Deficiency Complementation Group B

  • Deficiency, Molybdenum Cofactor, Complementation Group B
Neu-Laxova Syndrome 2

  • NLS2
Encephalomalacia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS08582 MOCS3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Canis familiaris MOCS3 VGNC VGNC:43307
Bos taurus MOCS3 VGNC VGNC:31549
Macaca mulatta MOCS3 VGNC VGNC:74772
Rattus norvegicus MOCS3 RGD RGD:1307044
Mus musculus MOCS3 MGD MGI:1916622
Felis catus MOCS3 VGNC VGNC:63550
Others MOCS3 NCBI