GYPA - glycophorin A (MNS blood group) Gene
Also Known as MN; GPA; MNS; GPSAT; PAS-2; CD235a; GPErik; HGpMiV; HGpMiXI; HGpSta(C)
生物種: Homo sapiens
About GYPA
This gene has 20 transcripts (splice variants), 35 orthologues, 2 paralogues and is associated with 2 phenotypes. Restricted expression toward bone marrow (RPKM 31.9).
Summary
Glycophorins A (GYPA) and B (GYPB) are major sialoglycoproteins of the human erythrocyte membrane which bear the antigenic determinants for the MN and Ss blood groups. In addition to the M or N and S or s Antigens that commonly occur in all populations, about 40 related variant phenotypes have been identified. These variants include all the variants of the Miltenberger complex and several isoforms of Sta, as well as Dantu, Sat, He, Mg, and deletion variants Ena, S-s-U- and Mk. Most of the variants are the result of gene recombinations between GYPA and GYPB. [provided by RefSeq, Jul 2008]
GYPA Products (3)
| mRNA | Protein | Name |
|---|---|---|
| NM_001308187.2 | NP_001295116.1 | glycophorin-A isoform 2 precursor |
| NM_001308190.2 | NP_001295119.1 | glycophorin-A isoform 3 |
| NM_002099.8 | NP_002090.4 | glycophorin-A isoform 1 precursor |
| Molecular Function GO Annotation | Evidence | 参考文献 | 由来 |
|---|---|---|---|
| enables identical protein binding |
IPI
IPI: Inferred from physical interaction
|
15067009 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
19438409 | GOA |
| Cellular Component GO Annotation | Evidence | 参考文献 | 由来 |
|---|---|---|---|
| part of ankyrin-1 complex |
IDA
IDA: Inferred from direct assay
|
35835865 | GOA |
GYPA Protein Structure
Glycophorin_A: Glycophorin A (28 - 147)
- 0
- 100
- 150 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
glycophorin-A |
|
GYPA Protein-protein interaction Information
|
Type
|
タンパク質名 | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | 参考文献 |
|---|---|---|---|---|---|---|---|
|
Intra
|
GYPA | P02724 | IL10RA | Homo sapiens | Q13651 | 32296183 | |
|
Intra
|
GYPA | P02724 | IL10RA | Homo sapiens | Q13651 | 32296183 | |
|
Intra
|
GYPA | P02724 | IL10RA | Homo sapiens | Q13651 | 32296183 | |
|
Intra
|
GYPA | P02724 | TMBIM6 | Homo sapiens | P55061 | 32296183 | |
|
Intra
|
GYPA | P02724 | TMEM237 | Homo sapiens | Q96Q45-2 | 32296183 | |
|
Intra
|
GYPA | P02724 | TMEM237 | Homo sapiens | Q96Q45-2 | 32296183 | |
|
Intra
|
GYPA | P02724 | TMEM237 | Homo sapiens | Q96Q45-2 | 32296183 | |
|
Intra
|
GYPA | P02724 | GPX8 | Homo sapiens | Q8TED1 | 32296183 | |
|
Intra
|
GYPA | P02724 | GPX8 | Homo sapiens | Q8TED1 | 32296183 | |
|
Intra
|
GYPA | P02724 | TLCD4 | Homo sapiens | Q96MV1 | 32296183 | |
|
Intra
|
GYPA | P02724 | TLCD4 | Homo sapiens | Q96MV1 | 32296183 | |
|
Intra
|
GYPA | P02724 | TLCD4 | Homo sapiens | Q96MV1 | 32296183 | |
|
Intra
|
GYPA | P02724 | GPRC5D | Homo sapiens | Q9NZD1 | 32296183 | |
|
Intra
|
GYPA | P02724 | GPRC5D | Homo sapiens | Q9NZD1 | 32296183 | |
|
Intra
|
GYPA | P02724 | GPRC5D | Homo sapiens | Q9NZD1 | 32296183 | |
|
Intra
|
GYPA | P02724 | TMEM154 | Homo sapiens | Q6P9G4 | 32296183 | |
|
Intra
|
GYPA | P02724 | TMEM154 | Homo sapiens | Q6P9G4 | 32296183 | |
|
Intra
|
GYPA | P02724 | TMEM154 | Homo sapiens | Q6P9G4 | 32296183 | |
|
Intra
|
GYPA | P02724 | GOLT1A | Homo sapiens | Q6ZVE7 | 32296183 | |
|
Intra
|
GYPA | P02724 | GOLT1A | Homo sapiens | Q6ZVE7 | 32296183 | |
|
Intra
|
GYPA | P02724 | GOLT1A | Homo sapiens | Q6ZVE7 | 32296183 | |
|
Intra
|
GYPA | P02724 | ANKRD29 | Homo sapiens | Q8N6D5 | 32296183 | |
|
Intra
|
GYPA | P02724 | ANKRD29 | Homo sapiens | Q8N6D5 | 32296183 | |
|
Intra
|
GYPA | P02724 | ANKRD29 | Homo sapiens | Q8N6D5 | 32296183 | |
|
Intra
|
GYPA | P02724 | SLC10A6 | Homo sapiens | Q3KNW5 | 32296183 | |
|
Intra
|
GYPA | P02724 | SLC10A6 | Homo sapiens | Q3KNW5 | 32296183 | |
|
Intra
|
GYPA | P02724 | SLC10A6 | Homo sapiens | Q3KNW5 | 32296183 | |
|
Intra
|
GYPA | P02724 | FAM209A | Homo sapiens | Q5JX71 | 32296183 | |
|
Intra
|
GYPA | P02724 | FAM209A | Homo sapiens | Q5JX71 | 32296183 | |
|
Intra
|
GYPA | P02724 | FAM209A | Homo sapiens | Q5JX71 | 32296183 | |
|
Intra
|
GYPA | P02724 | CLDN5 | Homo sapiens | O00501 | 32296183 | |
|
Intra
|
GYPA | P02724 | CLDN5 | Homo sapiens | O00501 | 32296183 | |
|
Intra
|
GYPA | P02724 | ELOVL4 | Homo sapiens | Q9GZR5 | 32296183 | |
|
Intra
|
GYPA | P02724 | ELOVL4 | Homo sapiens | Q9GZR5 | 32296183 | |
|
Intra
|
GYPA | P02724 | ELOVL4 | Homo sapiens | Q9GZR5 | 32296183 | |
|
Cross
|
GYPA | P02724 | EBP | Plasmodium reichenowi | Q9N9G9 | 24297912 | |
|
Cross
|
GYPA | P02724 | EBP | Plasmodium reichenowi | Q9N9G9 | 24297912 | |
|
Intra
|
GYPA | P02724 | EBA-175 | Plasmodium sp. chimpanzee clade C3 | V9XTM1 | 24297912 | |
|
Intra
|
GYPA | P02724 | EBA-175 | Plasmodium sp. chimpanzee clade C3 | V9XTM1 | 24297912 | |
|
Intra
|
GYPA | P02724 | FFAR2 | Homo sapiens | O15552 | 32296183 | |
|
Intra
|
GYPA | P02724 | FFAR2 | Homo sapiens | O15552 | 32296183 | |
|
Intra
|
GYPA | P02724 | LAPTM5 | Homo sapiens | Q13571 | 32296183 | |
|
Intra
|
GYPA | P02724 | LAPTM5 | Homo sapiens | Q13571 | 32296183 | |
|
Intra
|
GYPA | P02724 | LAPTM5 | Homo sapiens | Q13571 | 32296183 | |
|
Intra
|
GYPA | P02724 | SGTA | Homo sapiens | O43765 | 32296183 | |
|
Intra
|
GYPA | P02724 | SGTA | Homo sapiens | O43765 | 32296183 | |
|
Intra
|
GYPA | P02724 | EBP | Homo sapiens | Q15125 | 32296183 | |
|
Intra
|
GYPA | P02724 | EBP | Homo sapiens | Q15125 | 32296183 | |
|
Intra
|
GYPA | P02724 | EBP | Homo sapiens | Q15125 | 32296183 | |
|
Intra
|
GYPA | P02724 | SAR1A | Homo sapiens | Q9NR31 | 32296183 | |
|
Intra
|
GYPA | P02724 | SAR1A | Homo sapiens | Q9NR31 | 32296183 | |
|
Intra
|
GYPA | P02724 | SAR1A | Homo sapiens | Q9NR31 | 32296183 | |
|
Intra
|
GYPA | P02724 | SLC4A1 | Homo sapiens | P02730 | 19438409 | |
|
Intra
|
GYPA | P02724 | ccsb orf id: 2260 | Homo sapiens | EBI-22326698 | 32296183 | |
|
Intra
|
GYPA | P02724 | SLC4A1 | Homo sapiens | P02730 | 19438409 | |
|
Intra
|
GYPA | P02724 | SLC4A1 | Homo sapiens | P02730 | 19438409 | |
|
Intra
|
GYPA | P02724 | KEAP1 | Homo sapiens | Q14145 | 32296183 | |
|
Intra
|
GYPA | P02724 | GYPA | Homo sapiens | P02724 | 23155421 | |
|
Intra
|
GYPA | P02724 | KEAP1 | Homo sapiens | Q14145 | 32296183 | |
|
Intra
|
GYPA | P02724 | GYPA | Homo sapiens | P02724 | 14681217 | |
|
Intra
|
GYPA | P02724 | ccsb orf id: 2260 | Homo sapiens | EBI-22326698 | 32296183 | |
|
Intra
|
GYPA | P02724 | GYPA | Homo sapiens | P02724 | 15067009 | |
|
Intra
|
GYPA | P02724 | KEAP1 | Homo sapiens | Q14145 | 32296183 | |
|
Intra
|
GYPA | P02724 | EVA1A | Homo sapiens | Q9H8M9 | 32296183 | |
|
Intra
|
GYPA | P02724 | EVA1A | Homo sapiens | Q9H8M9 | 32296183 | |
|
Intra
|
GYPA | P02724 | EVA1A | Homo sapiens | Q9H8M9 | 32296183 | |
|
Intra
|
GYPA | P02724 | PDZK1IP1 | Homo sapiens | Q13113 | 32296183 | |
|
Intra
|
GYPA | P02724 | PDZK1IP1 | Homo sapiens | Q13113 | 32296183 | |
|
Intra
|
GYPA | P02724 | PDZK1IP1 | Homo sapiens | Q13113 | 32296183 | |
|
Intra
|
GYPA | P02724 | SGTB | Homo sapiens | Q96EQ0 | 32296183 | |
|
Intra
|
GYPA | P02724 | SGTB | Homo sapiens | Q96EQ0 | 32296183 | |
|
Intra
|
GYPA | P02724 | SGTB | Homo sapiens | Q96EQ0 | 32296183 | |
|
Intra
|
GYPA | P02724 | ERGIC3 | Homo sapiens | Q9Y282 | 32296183 | |
|
Intra
|
GYPA | P02724 | ERGIC3 | Homo sapiens | Q9Y282 | 32296183 | |
|
Intra
|
GYPA | P02724 | ERGIC3 | Homo sapiens | Q9Y282 | 32296183 | |
|
Intra
|
GYPA | P02724 | TMEM14B | Homo sapiens | Q9NUH8 | 32296183 | |
|
Intra
|
GYPA | P02724 | TMEM14B | Homo sapiens | Q9NUH8 | 32296183 | |
|
Intra
|
GYPA | P02724 | TMEM14B | Homo sapiens | Q9NUH8 | 32296183 | |
|
Cross
|
GYPA | P02724 | q8ibe8_plaf7 | Plasmodium falciparum | Q8IBE8 | 24297912 | |
|
Cross
|
GYPA | P02724 | q8ibe8_plaf7 | Plasmodium falciparum | Q8IBE8 | 24297912 |
Recombinant GYPA Proteins
| 製品番号 | 製品名 | アクセッション番号 | 純度 |
|---|---|---|---|
| HY-P71741 | GYPA/CD235a Protein, Human (P.pastoris, His) | A0A0C4DFT7 (L20-E91) | ≥ 90%, as determined by reducing SDS-PAGE. |
| HY-P72218 | GYPA/CD235a Protein, Human (GST) | A0A0C4DFT7 (L20-E91) | ≥ 90%, as determined by reducing SDS-PAGE. |
| HY-P72219 | GYPA/CD235a Protein, Human (His) | A0A0C4DFT7 (L20-E91) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P75151 | GYPA/CD235a Protein, Human (E24G, HEK293, His) | P02724-1 (S21-E91, E24G) | ≥ 95%, as determined by reducing SDS-PAGE. |
GYPA 抗体
| 製品番号 | 製品名 | アプリケーション | 反応性 |
|---|---|---|---|
| HY-P81406 | Glycophorin A Antibody (YA1151) | IHC-P | Human |
| HY-P81406A | Glycophorin A Antibody (YA1151)(PBS only) | IHC-P | Human |
| HY-P83666M | Human CD235 Antibody (APC) (YA3400) | FC | Human |
| HY-P85916 | Glycophorin A Antibody (YA5608) | IHC-P, WB, ICC/IF, ELISA | Human |
| HY-P87180 | CD235a Antibody (YA6871) | FC, ELISA | Human |
| HY-P87180A | CD235a Antibody (YA6871)(PBS only) | FC, ELISA | Human |
関連疾患
| Diseases | Alias | |
|---|---|---|
| Malaria |
|
|
| Hepatitis A |
|
|
| Pyridoxine-Responsive Sideroblastic Anemia |
|
|
| Hereditary Spherocytosis |
|
|
| Anemia, Autoimmune Hemolytic |
|
|
| Gastric Teratoma |
|
|
| Acute Erythroid Leukemia |
|
|
| Malignant Gastric Germ Cell Tumor |
|
|
| Diamond-Blackfan Anemia |
|
|
| Anemia, Congenital Dyserythropoietic, Type Ia |
|
|
| Carrion'S Disease |
|
|
| Hereditary Elliptocytosis |
|
|
| Duodenum Adenoma |
|
|
| Myelodysplastic Syndrome |
|
|
| Fetal Erythroblastosis |
|
|
| Myasthenic Syndrome, Congenital, 3a, Slow-Channel |
|
|
| Congenital Hemolytic Anemia |
|
|
| Anemia Of Prematurity |
|
|
| Myeloproliferative Syndrome, Transient |
|
|
| Sickle Cell Anemia |
|
|
| Hemoglobinopathy |
|
|
| Plasmodium Vivax Malaria |
|
|
| Beta-Thalassemia Major |
|
|
| Dehydrated Hereditary Stomatocytosis 1 With Or Without Pseudohyperkalemia And/Or Perinatal Edema |
|
|
| Parasitic Protozoa Infectious Disease |
|
|
| Hemoglobin D Disease |
|
|
| Glucosephosphate Dehydrogenase Deficiency |
|
|
| Hemolytic Anemia |
|
|
| Deficiency Anemia |
|
|
| Leukemia, Acute Myeloid |
|
|
Orthologs Information
| 生物種 | Symbol | 由来 | ID |
|---|---|---|---|
| Rattus norvegicus | GYPA | RGD | RGD:1582935 |
| Mus musculus | GYPA | MGD | MGI:95880 |
| Others | GYPA | NCBI |