製品番号: HY-115385

Lumichrome

(別名: ルミクローム)

2 Cited Publications

カスタマーレビュー

Based on 2 publication(s) in Google Scholar

Lumichrome, a photodegradation product of Riboflavin, is an endogenous compound in humans. Lumichrome inhibits human lung cancer cell growth and induces apoptosis via a p53-dependent mechanism. Lumichrom is the inhibitor for AKT/β-catenin signaling pathway.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

純度: 99.84%
CAS 番号: 1086-80-2
分子式: C₁₂H₁₀N₄O₂
分子量:242.24

保管条件:

Store at room temperature 3 years.

In solvent -80°C, 2 years , -20°C, 1 year

Lumichrome 構造式

CAS 番号: 1086-80-2

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Akt アイソフォーム固有の製品をすべて表示 :

NF-κB アイソフォーム固有の製品をすべて表示 :

ERK アイソフォーム固有の製品をすべて表示 :

p38 MAPK アイソフォーム固有の製品をすべて表示 :

体外実験

Lumichrome (0-100 μM, 24 h) exhibits cytotoxicity in cancer cells H292, A549 and H460 (IC₅₀ = 38, 54 and 79 μM, respectively), induces apoptosis in these cells, and inhibits the colony formation^[2].
Lumichrome (0-10 μM, 5-28 days) inhibits RANKL-induced osteoclastogenesis and bone resorption through inhibition of NFAT/NF-κB/MAPK/calcium signaling pathways^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[2]

Cell Line:

H292, A549 and H460
Concentration:

0-100 μM
Incubation Time:

24 h
Result:

Inhibited cell viability.

Western Blot Analysis^[2]

Cell Line:

H292, A549 and H460
Concentration:

0-50 μM
Incubation Time:

24 h
Result:

Increased expression of cleaved PARP, caspase-3/9, increased expression of p53.

体内実験

Lumichrome (7.5 mg/kg, ip, three times a week for 6 weeks) reduces bone loss and prevents osteoporosis in the ovariectomized (OVX) mouse model^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

OVX mouse model^[3]
Dosage:

7.5 mg/kg
Administration:

ip, three times a week for 6 weeks
Result:

Increased bone mineral density (BMD) and bone volume fraction (BV/TV) in OVX mice, and reduced the osteoclast surface/bone surface (Oc.S/BS) ratio.

化学情報

CAS 番号 1086-80-2
性状 Solid
分子量 242.24
分子式 C₁₂H₁₀N₄O₂
Color Light yellow to yellow
SMILES

O=C(N1)NC2=NC3=CC(C)=C(C)C=C3N=C2C1=O
別名

ルミクローム
Structure Classification
- Others
Initial Source
- Endogenous metabolite
輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Store at room temperature 3 years

In solvent	-80°C	2 years
	-20°C	1 year

Publications (2)

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Journal Impact Factor

Chem Eng J

2025 Sep 15.
J Ethnopharmacol

Desmodium styracifolium (Osb.) Merr. Extracts alleviate cholestatic liver disease by FXR pathway. [Abstract]

2024 Oct 23:118972. PMID: 39454708

溶剤 & 溶解度

体外:

DMSO : 2 mg/mL (8.26 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

4.1281 mL

20.6407 mL

41.2814 mL

5 mM

0.8256 mL

4.1281 mL

8.2563 mL

10 mM

---

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (277 KB)
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Bergh VJ, et al. Influence of formulation on photoinactivation of bacteria by lumichrome. Pharmazie. 2015;70(9):574-580. [Content Brief]

[2]. Chantarawong W, et al. Lumichrome Inhibits Human Lung Cancer Cell Growth and Induces Apoptosis via a p53-Dependent Mechanism. Nutr Cancer. 2019;71(8):1390-1402. [Content Brief]

[3]. Liu C, et al., Lumichrome inhibits osteoclastogenesis and bone resorption through suppressing RANKL-induced NFAT activation and calcium signaling. J Cell Physiol. 2018 Nov;233(11):8971-8983. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	4.1281 mL	20.6407 mL	41.2814 mL	103.2034 mL
DMSO	5 mM	0.8256 mL	4.1281 mL	8.2563 mL	20.6407 mL

Keywords

Lumichrome

2 Cited Publications

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Lumichrome

Apoptosis Compound Library

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Drug Fragment Library

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MedChemExpress（MCE）の使用を引用している文献 Lumichrome

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ERK アイソフォーム固有の製品をすべて表示