Neuroprotective agent 18
Neuroprotective agent 18 is a potent neuroprotective agent. Neuroprotective agent 18 inhibits the activity of NF-κB thereby significantly downregulating the expression of downstream pro-inflammatory mediators (TNF-α, IL-6) and inflammatory enzymes (COX-2) in the hippocampus. Neuroprotective agent 18 binds to AChE thereby partially inhibiting it and modulating cholinergic neurotransmission. Neuroprotective agent 18 can be used in research on Alzheimer's disease.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C21H22N2O5
- 分子量:382.41
-
保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
生物活性
|
NF-κB |
COX-2 |
IL-6 |
TNF-α |
AChE |
Neuroprotective agent 18 (compound M5) is capable of binding favorably to multiple proteins involved in neuroinflammation. Neuroprotective agent 18 exhibits moderate to strong docking score (-7.9 kcal/mol, -7.7 kcal/mol, -7.3 kcal/mol and -7.1 kcal/mol) for COX-2, TNF-α, IL-6 complex and NF-κB. Neuroprotective agent 18 produces a comparatively stronger docking score (-9.0 kcal/mol) for AChE[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Swiss albino mice (Male, 8-10 weeks, 25-30 g) received daily intraperitoneal injections of Scopolamine (1 mg/kg) for 6 days[1].
-
Dosage:1 mg/kg, 5 mg/kg, 10 mg/kg
-
Administration:i.p.; once daily; for 6 days
-
Result:Restored spatial learning and memory consolidation capabilities in a dose-dependent manner in the Morris Water Maze (MWM) test.
Effectively improved hippocampus-dependent short-term working memory in the Y-Maze Test.
Significantly reduced the concentrations of the pro-inflammatory cytokines TNF-α and IL-6 in the hippocampus in a dose-dependent manner, while simultaneously downregulating the expression levels of the inflammation-related enzyme COX-2 and the upstream inflammatory transcription factor NF-κB.
化学情報
-
分子量 382.41
-
分子式 C21H22N2O5
-
SMILES
O=C(ON=C/1CNCC2=CC=CC=C2)C1=C\C3=CC(OC)=C(OC)C(OC)=C3
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Neuroprotective agent 18 関連分類
HY-184935 関連分類
Powered by Bioz