PU3
PU3 is an Hsp90 inhibitor that competes with geldanamycin (GM) and others for the conserved ATP/ADP pocket of Hsp90. PU3 also induces degradation of proteins such as Her2 and inhibits breast cancer cell growth by causing retinoblastoma protein hypophosphorylation, G1 arrest, and cell differentiation. PU3 has the potential to be a cancer inhibitor..
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- CAS 番号: 352519-21-2
- 分子式: C19H25N5O3
- 分子量:371.43
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
Hsp90[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MCF7 | IC50 |
1 μM
Compound: 19, PU3
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Inhibition of Hsp90 in human MCF7 cells assessed as Her2 degradation
Inhibition of Hsp90 in human MCF7 cells assessed as Her2 degradation
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[PMID: 19017562] |
| NCI-H1975 | GI50 |
50 μM
Compound: 3, PU3
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Antiproliferative activity against gefitinib-resistant human NCI-H1975 cells after 1 to 3 days by MTS assay
Antiproliferative activity against gefitinib-resistant human NCI-H1975 cells after 1 to 3 days by MTS assay
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[PMID: 24345447] |
化学情報
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CAS 番号 352519-21-2
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分子量 371.43
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分子式 C19H25N5O3
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SMILES
NC1=C2N=C(N(C2=NC=N1)CCCC)CC3=CC(OC)=C(C(OC)=C3)OC
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
PU3 関連分類
HY-121881 関連分類
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