Rhodiolin
Based on 1 publication(s) in Google Scholar
Rhodiolin, a flavonoid, is an orally active glucose 6-phosphate isomerase (GPI) inhibitor. Rhodiolin inhibits papillary thyroid cancer (PTC) by targeting glycolysis enzyme glucose 6-phosphate isomerase GPI and suppressing PI3K/AKT/mTOR phosphorylation and induce apoptosis. Rhodiolin as a NS2B-NS3 protease inhibitor can disrupt dengue viral replication. Rhodiolin is also a potential candidate for developing anticancer strategies inhibiting CK1ε kinase. Rhodiolin can be used for the study of anti-tumor and anti-viral .
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98%
- CAS 番号: 86831-53-0
- 分子式: C25H20O10
- 分子量:480.42
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保管条件:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 Rhodiolin
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生物活性
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CK1ε |
PI3K |
Akt |
mTOR |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MDCK | CC50 |
>300 μM
Compound: 9
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Cytotoxicity against MDCK cells after 48 hrs by MTT assay
Cytotoxicity against MDCK cells after 48 hrs by MTT assay
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[PMID: 19729316] |
| MDCK | EC50 |
29.3 μM
Compound: 9
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Antiviral activity against influenza A virus H9N2 A/Chicken/Korea/MS96/96 infected in MDCK cells assessed as reduction in virus-induced cytopathic effect
Antiviral activity against influenza A virus H9N2 A/Chicken/Korea/MS96/96 infected in MDCK cells assessed as reduction in virus-induced cytopathic effect
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[PMID: 19729316] |
| MDCK | EC50 |
41.7 μM
Compound: 9
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Antiviral activity against influenza A virus H1N1 A/PR/8/34 infected in MDCK cells assessed as reduction in virus-induced cytopathic effect
Antiviral activity against influenza A virus H1N1 A/PR/8/34 infected in MDCK cells assessed as reduction in virus-induced cytopathic effect
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[PMID: 19729316] |
Rhodiolin (0-40 μM, 24 h) induces cell cycle arrest at G1/S phase in PTC cells[1].
Rhodiolin (0-40 μM, 12-24 h) blocks glycolysis by downregulating GPI expression and then inhibited the PI3K/Akt/mTOR signaling pathway which, in turn, inhibits the proliferation and induces the apoptosis of PTC cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:PTC cells
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Concentration:10, 20 and 40 μM
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Incubation Time:24 h
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Result:Showed a dose-dependent reduction in S-phase cells.
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Cell Line:PTC cells
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Concentration:10, 20 and 40 μM
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Incubation Time:12 h
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Result:Observed A dose-dependent increase in the percentage of cells undergoing early apoptosis and late apoptosis.
Caused dose-dependent reduction in MMP.
Reduced the number of mitochondria in tumor cells significantly while increasing the intracellular oxidation level.
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Cell Line:PTC cells
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Concentration:10, 20 and 40 μM
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Incubation Time:24 h
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Result:Decreased the expression of cyclin E, CDK4, and CDK2 .
Increased the expression of the expression of p21 and p27.
Reduced phosphorylation of the PI3K/Akt/mTOR signaling pathway significantly.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:MH-134 hepatoma xenograft model established in 6 weeks old female C57BL/6 mice[1]
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Dosage:10 and 25 mg/kg
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Administration:Intragastric administration (i.g.), every two days for 10 days
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Result:Reduced the tumor-cell density significantly.
Showed a dose-dependent reduction in the number of Ki-67-positive cells and GPI expression.
Induced significant apoptosis in tumor tissue.
No signs of hepatotoxicity were evident.
No morphological abnormalities or signs of inflammation were detected in the heart, liver, spleen, lungs, or kidneys of mice.
化学情報
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CAS 番号 86831-53-0
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性状 Solid
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分子量 480.42
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分子式 C25H20O10
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Color Light yellow to yellow
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SMILES
O=C1C2=C(O)C=C(O[C@H](C3=CC(OC)=C(O)C=C3)[C@@H](CO)O4)C4=C2OC(C5=CC=C(O)C=C5)=C1O
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (1)
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Journal Impact Factor
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Most Recent
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Phytomedicine
Rhodiolin inhibits the PI3K/AKT/mTOR signaling pathway via the glycolytic enzyme GPI in human papillary thyroid cancer. [Abstract]2024 Jun 25:132:155804. PMID: 38943696
純度とドキュメンテーション
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データシート (278 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Bo J, et al. Rhodiolin inhibits the PI3K/AKT/mTOR signaling pathway via the glycolytic enzyme GPI in human papillary thyroid cancer. Phytomedicine. 2024 Sep;132:155804. [Content Brief]
[2]. Hakami MA, et al. Identification of potential casein kinase I isoform epsilon inhibitors from phytoconstituents: implications for targeted anticancer therapeutics. J Biomol Struct Dyn. 2025 Apr 29:1-13. [Content Brief]
[3]. Purohit P, et al. Targeting the DENV NS2B-NS3 protease with active antiviral phytocompounds: structure-based virtual screening, molecular docking and molecular dynamics simulation studies. J Mol Model. 2022 Oct 24;28(11):365. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Rhodiolin 関連分類
HY-N6841 関連分類
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