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製品番号: HY-124183

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SX-576

SX-576 is a CXCR1 and CXCR2 antagonist with IC₅₀ values of 31 nM and 21 nM, respectively. SX-576 inhibits neutrophil infiltration in a rat model of pulmonary inflammation. SX-576 can be used in studies related to pulmonary inflammation.

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CAS 番号: 1240494-14-7
分子式: C₂₀H₁₅BF₄N₂O₄S
分子量:466.21

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

SX-576 構造式

CAS 番号: 1240494-14-7

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

CXCR アイソフォーム固有の製品をすべて表示 :

体外実験

SX-576 inhibits GROα-mediated intracellular calcium release in isolated human polymorphonuclear leukocytes (PMNs) with an IC₅₀ of 22 ± 3 nM^[1].
SX-576 acts as a full antagonist in CXCR2-expressing cells in the PathHunter β-arrestin assay with an IC₅₀ of 130 ± 6 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

SX-576 (1 mg/kg; i.v.; three doses) potently inhibits ozone-induced pulmonary inflammation in rats, reducing neutrophil influx to near undetectable levels, lowering macrophage counts, and decreasing lung leakage^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Sprague-Dawley rats^[1]
Dosage:

1 mg/kg
Administration:

i.v.; three doses (at t=0, t=5, t=9 hours)
Result:

Significantly decreased neutrophil influx to the lungs to near undetectable levels.
Significantly reduced macrophage influx.
Significantly reduced ozone-induced lung leakage, as measured by reduced BALF protein levels.

化学情報

CAS 番号 1240494-14-7
分子量 466.21
分子式 C₂₀H₁₅BF₄N₂O₄S
SMILES

O=C(NC1=CC=C(F)C=C1)C2=CN=C(SCC3=CC(OC(F)(F)F)=CC=C3B(O)O)C=C2
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Maeda DY, et al. Boronic acid-containing CXCR1/2 antagonists: Optimization of metabolic stability, in vivo evaluation, and a proposed receptor binding model. Bioorg Med Chem Lett. 2015 Jun 1;25(11):2280-4. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

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生物活性
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SX-576

CXCR アイソフォーム固有の製品をすべて表示

生物活性

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

SX-576 関連分類

HY-124183 関連分類