Cat. No.: HY-110117

BIRT 377

4 Cited Publications

고객리뷰

Based on 4 publication(s) in Google Scholar

BIRT 377 is a potent amd orally bioavailable inhibitor of the interaction between intercellular adhesion molecule-1 (ICAM-1) and lymphocyte function-associated antigen-1 (LFA-1). BIRT 377 also inhibits the production of IL-2 in vivo. BIRT 377 can be used for researching inflammatory and immune disorders.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

Purity: 99.82%
CAS No.: 213211-10-0
화학식: C₁₈H₁₅BrCl₂N₂O₂
분자량:442.13

보관:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

BIRT 377 Chemical Structure

CAS No.: 213211-10-0

사이즈

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재고

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Publications (4)
용액&용해도
- In Vitro
순도&문서
References
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

IL-2

All Integrin Isoforms :

All Interleukin Related Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
H1-HeLa	IC₅₀	26 nM Compound: BIRT-377	Inhibitory concentration against leukocyte function-associated antigen-1 in HSB-2 human lymphoblast and H1HeLa cell adhesion assay Inhibitory concentration against leukocyte function-associated antigen-1 in HSB-2 human lymphoblast and H1HeLa cell adhesion assay	[PMID: 15686933]
JY	IC₅₀	0.24 μM Compound: 1	Concentration required to inhibit aggregation of JY cells Concentration required to inhibit aggregation of JY cells	[PMID: 15481974]

In Vitro

BIRT 377 (20 μM, 6 h) inhibits the mRNA and protein expression of EMT-related markers ZEB2 and Vementin in HT-29 cell whem cocultured with LAD2 cell^[2].
BIRT 377 (20 μM, 24 h) inhibits the cell migration of HT-29, when cocultured with LAD2^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[2]

Cell Line:

HT-29
Concentration:

20 μM
Incubation Time:

6 h
Result:

Inhibited the protein expression of ZEB2 and Vementin.

In Vivo

BIRT 377 (3-10 mg/kg, po, once daily for 14 days) inhibits the production of human IgG in hPBMC-injected mouse models, with an effect comparable to that of anti-LFA-1 antibodies^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

hPBMC-injected mouse models^[3]
Dosage:

3-10 mg/kg
Administration:

po, once daily for 14 days
Result:

Inhibited the production of human IgG.

Chemical Information

CAS No. 213211-10-0
Appearance Solid
분자량 442.13
화학식 C₁₈H₁₅BrCl₂N₂O₂
Color White to off-white
SMILES

O=C1N(C2=CC(Cl)=CC(Cl)=C2)C(N(C)[C@]1(C)CC3=CC=C(Br)C=C3)=O
선적

Room temperature in continental US; may vary elsewhere.

보관

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (4)

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Anal Chem

Exposome-Scale Investigation of Cl-/Br-Containing Chemicals Using High-Resolution Mass Spectrometry, Multistage Machine Learning, and Cloud Computing. [Abstract]

2025 Jun 3;97(21):11099-11109. PMID: 40401576
PNAS Nexus

Low-affinity LFA1-dependent outside-in signaling mediates avidity modulation via the Rabin8-Rab8 axis. [Abstract]

2024 Aug 8;3(8):pgae332. PMID: 39170909
bioRxiv

Mast cells interact directly with colorectal cancer cells to promote epithelial-to-mesenchymal transition. [Abstract]

2025 Mar 19:2025.03.19.644113. PMID: 40166179
Res Sq

2024 Jun 04.

용액&용해도

In Vitro:

DMSO : 100 mg/mL (226.18 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.2618 mL

11.3089 mL

22.6178 mL

5 mM

0.4524 mL

2.2618 mL

4.5236 mL

10 mM

0.2262 mL

1.1309 mL

2.2618 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Kelly TA, et al. Cutting edge: a small molecule antagonist of LFA-1-mediated cell adhesion. J Immunol. 1999;163(10):5173-5177. [Content Brief]

[2]. Lanzloth R, et al. Mast cells interact directly with colorectal cancer cells to promote epithelial-to-mesenchymal transition[J]. bioRxiv, 2025: 2025.03. 19.644113.

[3]. Winquist RJ, et al., The role of leukocyte function-associated antigen-1 in animal models of inflammation. Eur J Pharmacol. 2001 Oct 19;429(1-3):297-302. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.2618 mL	11.3089 mL	22.6178 mL	56.5445 mL
	5 mM	0.4524 mL	2.2618 mL	4.5236 mL	11.3089 mL
	10 mM	0.2262 mL	1.1309 mL	2.2618 mL	5.6544 mL
	15 mM	0.1508 mL	0.7539 mL	1.5079 mL	3.7696 mL
	20 mM	0.1131 mL	0.5654 mL	1.1309 mL	2.8272 mL
	25 mM	0.0905 mL	0.4524 mL	0.9047 mL	2.2618 mL
	30 mM	0.0754 mL	0.3770 mL	0.7539 mL	1.8848 mL
	40 mM	0.0565 mL	0.2827 mL	0.5654 mL	1.4136 mL
	50 mM	0.0452 mL	0.2262 mL	0.4524 mL	1.1309 mL
	60 mM	0.0377 mL	0.1885 mL	0.3770 mL	0.9424 mL
	80 mM	0.0283 mL	0.1414 mL	0.2827 mL	0.7068 mL
	100 mM	0.0226 mL	0.1131 mL	0.2262 mL	0.5654 mL

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BIRT 377

Immunology/Inflammation Compound Library

Covalent Screening Library

Differentiation Inducing Compound Library

Cytoskeleton Compound Library

Orally Active Compound Library

Angiogenesis-Related Compound Library

Heterocyclic Compound Library

Membrane Protein-targeted Compound Library

Cytokine Inhibitors Library

Extracellular Vesicles (EVs) Compound Library

Radioprotector Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Covalent Screening Library Plus

Bioactive Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

High-Throughput Bioactive Compound Library

Publications Citing Use of MedChemExpress (MCE) BIRT 377

All Integrin Isoforms

All Interleukin Related Isoforms

Biological Activity

Chemical Information

Publications (4)

용액&용해도

순도&문서

References

Help & FAQs

Complete Stock Solution Preparation Table

BIRT 377

Immunology/Inflammation Compound Library

Covalent Screening Library

Differentiation Inducing Compound Library

Cytoskeleton Compound Library

Orally Active Compound Library

Angiogenesis-Related Compound Library

Heterocyclic Compound Library

Membrane Protein-targeted Compound Library

Cytokine Inhibitors Library

Extracellular Vesicles (EVs) Compound Library

Radioprotector Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Covalent Screening Library Plus

Bioactive Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

High-Throughput Bioactive Compound Library

Publications Citing Use of MedChemExpress (MCE) BIRT 377

All Integrin Isoforms

All Interleukin Related Isoforms

Biological Activity

Chemical Information

Publications (4)

용액&용해도

순도&문서

References

Help & FAQs

Complete Stock Solution Preparation Table

BIRT 377 Related Classifications

HY-110117 Related Classifications