1296818-77-3
1296818-77-3
Chemical Structure
Nesvacumab
- CAS No.: 1296818-77-3
- Formula:N/A
- Molecular Weight:(144.86 kDa)
IUPAC Name: N-([1,1'-biphenyl]-3-yl)-4-hydroxy-1-(4-methoxybenzyl)-1H-1,2,3-triazole-5-carboxamide
SMILES: [Nesvacumab]
Biological Activity: Nesvacumab is a fully human immunoglobulin G1 (IgG1) monoclonal antibody that specifically binds and inactivates the Tie2 receptor ligand Angiopoietin-2 (Ang2) with high affinity, but shows no binding to Ang1. Nesvacumab can be used in vascular researches[1][2].
| Cat. No. | 상품명 | Purity | 제품 설명 | Pricing | |||||||||||||||||||
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Nesvacumab | 99.11% | Nesvacumab is a fully human immunoglobulin G1 (IgG1) monoclonal antibody that specifically binds and inactivates the Tie2 receptor ligand Angiopoietin-2 (Ang2) with high affinity, but shows no binding to Ang1. Nesvacumab can be used in vascular researches. | ||||||||||||||||||||
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References
- [1]. Kyriakos P Papadopoulos, et al. A Phase I First-in-Human Study of Nesvacumab (REGN910), a Fully Human Anti-Angiopoietin-2 (Ang2) Monoclonal Antibody, in Patients with Advanced Solid Tumors. Clin Cancer Res. 2016 Mar 15;22(6):1348-55. [Content Brief]
- [2]. Vakili S, et al. Angiopoietin-2 reverses endothelial cell dysfunction in progeria vasculature. Aging Cell. 2025 Feb;24(2):e14375. [Content Brief]
