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Cat. No.: HY-157210

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CDK7-IN-26

CDK7-IN-26 (compound 36) is an orally active CDK7 inhibitor (IC₅₀: 7.4 nM). CDK7-IN-26 potently inhibits the growth of triple-negative breast cancer (TNBC) cell line-derived xenograft (CDX) tumors in vivo and inhibits MDA-MB-453 cells in vitro with an IC₅₀ of 0.15 μM.

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CAS No.: 3024545-79-4
화학식: C₂₂H₂₂FN₆OPS
분자량:468.49

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (276 KB)

CDK7-IN-26 Chemical Structure

CAS No.: 3024545-79-4

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

IC50: 7.4 nM (CDK7)^[1]

All CDK Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
MDA-MB-231	EC₅₀	0.32 μM Compound: 36	Antiproliferative activity against human MDA-MB-231 cells incubated for 120 hrs by CCK-8 assay Antiproliferative activity against human MDA-MB-231 cells incubated for 120 hrs by CCK-8 assay	[PMID: 38000213]
MDA-MB-453	EC₅₀	0.15 μM Compound: 36	Antiproliferative activity against human MDA-MB-453 cells incubated for 120 hrs by CCK-8 assay Antiproliferative activity against human MDA-MB-453 cells incubated for 120 hrs by CCK-8 assay	[PMID: 38000213]

Chemical Information

CAS No. 3024545-79-4
분자량 468.49
화학식 C₂₂H₂₂FN₆OPS
SMILES

O=P(C)(C1=C(C=CC2=C1NC=C2C3=NC(N[C@H]4C[C@H](F)CNC4)=NC5=C3SC=C5)C#N)C
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zhang H et al. Discovery and optimization of thieno [3, 2-d] pyrimidine derivatives as highly selective inhibitors of cyclin-dependent kinase 7[J]. European Journal of Medicinal Chemistry, 2023: 115955.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
순도&문서
References

상품명:
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수량:
MCE Japan Authorized Agent:

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CAS No.:
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CDK7-IN-26

All CDK Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

CDK7-IN-26 Related Classifications

HY-157210 Related Classifications